Discriminatory Detection of Cysteine and Homocysteine Based on Dialdehyde-Functionalized Aggregation-Induced Emission Fluorophores

We demonstrate a concept‐proof work of using fluorescence (FL) “turn‐on” probes for the discriminatory detection of cysteine (Cys) over homocysteine (Hcy). The fluorogens are provided with aggregation‐induced emission (AIE) characteristic and functionalized with two aldehyde‐groups (DMTPS‐ALD and TP...

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Published inChemistry : a European journal Vol. 19; no. 2; pp. 613 - 620
Main Authors Mei, Ju, Wang, Yijia, Tong, Jiaqi, Wang, Jian, Qin, Anjun, Sun, Jing Zhi, Tang, Ben Zhong
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 07.01.2013
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
Subjects
aggregation
Aldehydes
Aldehydes - chemistry
Amino acids
Buffers
Chemistry
Chemistry Techniques, Analytical - instrumentation
Cysteine
Cysteine - analysis
Cysteine - blood
Cysteine - chemistry
Dimethyl Sulfoxide - chemistry
Discrimination
Emission
Fluorescence
fluorescence spectroscopy
Fluorescent Dyes - chemistry
fluorescent probes
Homocysteine
Homocysteine - analysis
Homocysteine - blood
Homocysteine - chemistry
Humans
Isomerism
Reaction kinetics
Solubility
Spectrometry, Fluorescence
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Abstract We demonstrate a concept‐proof work of using fluorescence (FL) “turn‐on” probes for the discriminatory detection of cysteine (Cys) over homocysteine (Hcy). The fluorogens are provided with aggregation‐induced emission (AIE) characteristic and functionalized with two aldehyde‐groups (DMTPS‐ALD and TPE‐ALD). All the detections were carried out in a biocompatible medium (10 mM HEPES buffer and DMSO, pH 7.4). In principle, the formation of thiazinane/thiazolidine through the chemical reaction of aldehydes on the probe molecules and the residue of Cys/Hcy determines the selective recognition of Cys and Hcy over other amino acids and glucose. The FL responses originate from the AIE property of thiazinane/thiazolidine resultants, which have low solubility and precipitate (aggregate) in the detection medium. The discrimination between Cys and Hcy comes from the difference in reaction kinetics of TPE‐ALD/DMTPS‐ALD with Cys and Hcy, thereby the FL responses show different time courses and intensity enhancement. It is worth noting that TPE‐ALD outshined the other two probes in performance with fast response, a high FL enhancement up to 16‐fold, high sensitivity, and good specificity and selectivity. Moreover, its FL response threshold at 250 μM is very close to the lower limit of the normal level of Cys in human plasma, which implies that TPE‐ALD could be applied as a potential indicator of Cys deficiency. Aldehyde‐functionalized fluorogens with aggregation‐induced emission (AIE) characteristics have been used as fluorescence “turn‐on” probes for the discriminatory detection of cysteine (Cys) over homocysteine (Hcy; see figure). The underlying mechanism for the discrimination is the kinetic difference of the reactions and the solubility difference between the fluorogens and the probe–analyte adducts. This proof‐of‐concept study indicates that this mechanism may be common to all the dialdehyde‐substituted AIE‐active molecules.
AbstractList We demonstrate a concept-proof work of using fluorescence (FL) "turn-on" probes for the discriminatory detection of cysteine (Cys) over homocysteine (Hcy). The fluorogens are provided with aggregation-induced emission (AIE) characteristic and functionalized with two aldehyde-groups (DMTPS-ALD and TPE-ALD). All the detections were carried out in a biocompatible medium (10 mM HEPES buffer and DMSO, pH 7.4). In principle, the formation of thiazinane/thiazolidine through the chemical reaction of aldehydes on the probe molecules and the residue of Cys/Hcy determines the selective recognition of Cys and Hcy over other amino acids and glucose. The FL responses originate from the AIE property of thiazinane/thiazolidine resultants, which have low solubility and precipitate (aggregate) in the detection medium. The discrimination between Cys and Hcy comes from the difference in reaction kinetics of TPE-ALD/DMTPS-ALD with Cys and Hcy, thereby the FL responses show different time courses and intensity enhancement. It is worth noting that TPE-ALD outshined the other two probes in performance with fast response, a high FL enhancement up to 16-fold, high sensitivity, and good specificity and selectivity. Moreover, its FL response threshold at 250 μM is very close to the lower limit of the normal level of Cys in human plasma, which implies that TPE-ALD could be applied as a potential indicator of Cys deficiency.
We demonstrate a concept-proof work of using fluorescence (FL) "turn-on" probes for the discriminatory detection of cysteine (Cys) over homocysteine (Hcy). The fluorogens are provided with aggregation-induced emission (AIE) characteristic and functionalized with two aldehyde-groups (DMTPS-ALD and TPE-ALD). All the detections were carried out in a biocompatible medium (10mM HEPES buffer and DMSO, pH7.4). In principle, the formation of thiazinane/thiazolidine through the chemical reaction of aldehydes on the probe molecules and the residue of Cys/Hcy determines the selective recognition of Cys and Hcy over other amino acids and glucose. The FL responses originate from the AIE property of thiazinane/thiazolidine resultants, which have low solubility and precipitate (aggregate) in the detection medium. The discrimination between Cys and Hcy comes from the difference in reaction kinetics of TPE-ALD/DMTPS-ALD with Cys and Hcy, thereby the FL responses show different time courses and intensity enhancement. It is worth noting that TPE-ALD outshined the other two probes in performance with fast response, a high FL enhancement up to 16-fold, high sensitivity, and good specificity and selectivity. Moreover, its FL response threshold at 250μM is very close to the lower limit of the normal level of Cys in human plasma, which implies that TPE-ALD could be applied as a potential indicator of Cys deficiency. [PUBLICATION ABSTRACT]
We demonstrate a concept‐proof work of using fluorescence (FL) “turn‐on” probes for the discriminatory detection of cysteine (Cys) over homocysteine (Hcy). The fluorogens are provided with aggregation‐induced emission (AIE) characteristic and functionalized with two aldehyde‐groups (DMTPS‐ALD and TPE‐ALD). All the detections were carried out in a biocompatible medium (10 mM HEPES buffer and DMSO, pH 7.4). In principle, the formation of thiazinane/thiazolidine through the chemical reaction of aldehydes on the probe molecules and the residue of Cys/Hcy determines the selective recognition of Cys and Hcy over other amino acids and glucose. The FL responses originate from the AIE property of thiazinane/thiazolidine resultants, which have low solubility and precipitate (aggregate) in the detection medium. The discrimination between Cys and Hcy comes from the difference in reaction kinetics of TPE‐ALD/DMTPS‐ALD with Cys and Hcy, thereby the FL responses show different time courses and intensity enhancement. It is worth noting that TPE‐ALD outshined the other two probes in performance with fast response, a high FL enhancement up to 16‐fold, high sensitivity, and good specificity and selectivity. Moreover, its FL response threshold at 250 μM is very close to the lower limit of the normal level of Cys in human plasma, which implies that TPE‐ALD could be applied as a potential indicator of Cys deficiency. Aldehyde‐functionalized fluorogens with aggregation‐induced emission (AIE) characteristics have been used as fluorescence “turn‐on” probes for the discriminatory detection of cysteine (Cys) over homocysteine (Hcy; see figure). The underlying mechanism for the discrimination is the kinetic difference of the reactions and the solubility difference between the fluorogens and the probe–analyte adducts. This proof‐of‐concept study indicates that this mechanism may be common to all the dialdehyde‐substituted AIE‐active molecules.
Abstract We demonstrate a concept‐proof work of using fluorescence (FL) “turn‐on” probes for the discriminatory detection of cysteine (Cys) over homocysteine (Hcy). The fluorogens are provided with aggregation‐induced emission (AIE) characteristic and functionalized with two aldehyde‐groups (DMTPS‐ALD and TPE‐ALD). All the detections were carried out in a biocompatible medium (10 m M HEPES buffer and DMSO, pH 7.4). In principle, the formation of thiazinane/thiazolidine through the chemical reaction of aldehydes on the probe molecules and the residue of Cys/Hcy determines the selective recognition of Cys and Hcy over other amino acids and glucose. The FL responses originate from the AIE property of thiazinane/thiazolidine resultants, which have low solubility and precipitate (aggregate) in the detection medium. The discrimination between Cys and Hcy comes from the difference in reaction kinetics of TPE‐ALD/DMTPS‐ALD with Cys and Hcy, thereby the FL responses show different time courses and intensity enhancement. It is worth noting that TPE‐ALD outshined the other two probes in performance with fast response, a high FL enhancement up to 16‐fold, high sensitivity, and good specificity and selectivity. Moreover, its FL response threshold at 250 μ M is very close to the lower limit of the normal level of Cys in human plasma, which implies that TPE‐ALD could be applied as a potential indicator of Cys deficiency.
We demonstrate a concept-proof work of using fluorescence (FL) "turn-on" probes for the discriminatory detection of cysteine (Cys) over homocysteine (Hcy). The fluorogens are provided with aggregation-induced emission (AIE) characteristic and functionalized with two aldehyde-groups (DMTPS-ALD and TPE-ALD). All the detections were carried out in a biocompatible medium (10mM HEPES buffer and DMSO, pH7.4). In principle, the formation of thiazinane/thiazolidine through the chemical reaction of aldehydes on the probe molecules and the residue of Cys/Hcy determines the selective recognition of Cys and Hcy over other amino acids and glucose. The FL responses originate from the AIE property of thiazinane/thiazolidine resultants, which have low solubility and precipitate (aggregate) in the detection medium. The discrimination between Cys and Hcy comes from the difference in reaction kinetics of TPE-ALD/DMTPS-ALD with Cys and Hcy, thereby the FL responses show different time courses and intensity enhancement. It is worth noting that TPE-ALD outshined the other two probes in performance with fast response, a high FL enhancement up to 16-fold, high sensitivity, and good specificity and selectivity. Moreover, its FL response threshold at 250 mu M is very close to the lower limit of the normal level of Cys in human plasma, which implies that TPE-ALD could be applied as a potential indicator of Cys deficiency. Aldehyde-functionalized fluorogens with aggregation-induced emission (AIE) characteristics have been used as fluorescence "turn-on" probes for the discriminatory detection of cysteine (Cys) over homocysteine (Hcy; see figure). The underlying mechanism for the discrimination is the kinetic difference of the reactions and the solubility difference between the fluorogens and the probe-analyte adducts. This proof-of-concept study indicates that this mechanism may be common to all the dialdehyde-substituted AIE-active molecules.
Author Sun, Jing Zhi
Wang, Jian
Mei, Ju
Tong, Jiaqi
Qin, Anjun
Wang, Yijia
Tang, Ben Zhong
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  organization: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science & Engineering, Zhejiang University, No. 38, Zheda Road, Hangzhou 310027 (P.R. China), Fax: (+86) 571-87953734
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  surname: Wang
  fullname: Wang, Yijia
  organization: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science & Engineering, Zhejiang University, No. 38, Zheda Road, Hangzhou 310027 (P.R. China), Fax: (+86) 571-87953734
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  surname: Tong
  fullname: Tong, Jiaqi
  organization: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science & Engineering, Zhejiang University, No. 38, Zheda Road, Hangzhou 310027 (P.R. China), Fax: (+86) 571-87953734
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  organization: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science & Engineering, Zhejiang University, No. 38, Zheda Road, Hangzhou 310027 (P.R. China), Fax: (+86) 571-87953734
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  surname: Qin
  fullname: Qin, Anjun
  organization: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science & Engineering, Zhejiang University, No. 38, Zheda Road, Hangzhou 310027 (P.R. China), Fax: (+86) 571-87953734
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  givenname: Jing Zhi
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  fullname: Sun, Jing Zhi
  email: sunjz@zju.edu.cn
  organization: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science & Engineering, Zhejiang University, No. 38, Zheda Road, Hangzhou 310027 (P.R. China), Fax: (+86) 571-87953734
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  givenname: Ben Zhong
  surname: Tang
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  email: tangbenz@ust.hk
  organization: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science & Engineering, Zhejiang University, No. 38, Zheda Road, Hangzhou 310027 (P.R. China), Fax: (+86) 571-87953734
BackLink https://www.ncbi.nlm.nih.gov/pubmed/23193021$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1021/am201677r
10.1021/ja0318838
10.1021/ja208883h
10.1016/j.chroma.2009.02.083
10.3390/s120302969
10.1002/anie.200461844
10.1021/ac801020v
10.1002/ange.200803194
10.1016/j.tetlet.2010.07.182
10.1039/c1jm12673c
10.1039/c0cc02381g
10.1039/C0JM02497J
10.1016/S0039-9140(03)00232-7
10.1039/c1cs15113d
10.1021/ja107086y
10.1146/annurev.med.49.1.31
10.1002/cbic.200800282
10.1007/s00726-008-0167-x
10.1016/j.aca.2009.04.034
10.1007/s10904-005-5546-0
10.1002/ange.200800169
10.1039/c2jm32892e
10.1039/b405238b
10.1039/c2jm31368e
10.1002/ange.201103759
10.1021/ac9002722
10.1088/0957-4484/23/30/305503
10.1016/j.cplett.2004.12.103
10.1021/ja00752a040
10.1021/ja031987i
10.1039/C1SC00688F
10.1039/b904665h
10.1039/b814581d
10.1039/C1JM13556B
10.1021/ac010541m
10.1039/c2cc00093h
10.1007/s00216-009-2643-x
10.1002/anie.201103759
10.1039/c1cc11990g
10.1002/ange.200461844
10.1021/ac990541a
10.1039/b105159h
10.1039/c0cc00630k
10.1021/ja302369e
10.1021/ja802273p
10.1002/anie.201104533
10.1016/S0039-9140(03)00173-5
10.1039/c2sc00762b
10.1021/ol900376r
10.1002/adfm.201102191
10.1016/j.jpba.2008.08.033
10.1056/NEJMoa011613
10.1021/ac071061j
10.1002/anie.200800169
10.1021/om0494216
10.1002/ange.201104533
10.1016/j.cbpa.2008.07.028
10.1021/nl0727563
10.1016/j.biomaterials.2011.10.040
10.1002/adma.201101714
10.1021/ja051145e
10.1016/j.dyepig.2011.10.013
10.1016/S0021-9673(00)00713-5
10.1039/b907379e
10.1039/c0an00943a
10.1039/b921610c
10.1021/cm021715z
10.1039/b405642f
10.1039/c2cc32038j
10.1039/b925092a
10.1039/b505683g
10.1038/nature09472
10.1021/ja036297t
10.1002/anie.200803194
10.2116/analsci.27.409
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References X. F. Guo, H. Wang, Y. H. Guo, Z. X. Zhang, H. S. Zhang, J. Chromatogr. A 2009, 1216, 3874-3880.
Y. Ren, Y. Dong, J. W. Y. Lam, B. Z. Tang, K. S. Wong, Chem. Phys. Lett. 2005, 402, 468-473
E. Weerapana, C. Wang, G. M. Simon, F. Richter, S. Khare, M. B. D. Dillon, D. A. Bachovchin, K. Mowen, D. Baker, B. F. Cravatt, Nature 2010, 468, 790-795.
K. Amarnath, V. Amarnath, K. Amarnath, H. L. Valentine, W. M. Valentine, Talanta 2003, 60, 1229-1238
H. Shi, J. Liu, J. Geng, B. Z. Tang, B. Liu, J. Am. Chem. Soc. 2012, 134, 9569-9572.
Q. Zhao, K. Li, S. Chen, A. Qin, D. Ding, S. Zhang, Y. Liu, B. Liu, J. Z. Sun, B. Z. Tang, J. Mater. Chem. 2012, 22, 15128-15135
J. Y. Shao, H. Y. Sun, H. M. Guo, S. M. Ji, J. Z. Zhao, W. T. Wu, X. L. Yuan, C. L. Zhang, T. D. James, Chem. Sci. 2012, 3, 1049-1061.
M. Wang, X. Gu, G. Zhang, D. Zhang, D. Zhu, Anal. Chem. 2009, 81, 4444-4449
Y.-B. Ruan, A.-F. Li, J.-S. Zhao, J.-S. Shen, Y.-B. Jiang, Chem. Commun. 2010, 46, 4938-4940
Y. Q. Dong, J. W. Y. Lam, Z. Li, H. Tong, Y. P. Dong, X. D. Feng, B. Z. Tang, J. Inorg. Organomet. Polym. Mater. 2005, 15, 287-291.
Angew. Chem. Int. Ed. 2004, 43, 6336-6338
Angew. Chem. Int. Ed. 2008, 47, 7883-7887
J. V. Ros-Lis, B. García, D. Jiménez, R. Martínez-Máñez, F. Sancenón, J. Soto, F. Gonzalvo, M. C. Valldecabres, J. Am. Chem. Soc. 2004, 126, 4064-4065
W. Wei, X. Liang, G. Hu, Y. Guo, S. Shao, Tetrahedron Lett. 2011, 52, 1422-1425
F. Tanaka, N. Mase, C. F. Barbas, Chem. Commun. 2004, 1762-1763
Angew. Chem. Int. Ed. 2008, 47, 7602-7625
L. Aubouy, P. Gerbier, N. Huby, G. Wantz, L. Vignau, L. Hirsch, J. M. Janot, New J. Chem. 2004, 28, 1086-1090
W. Hao, A. McBride, S. McBride, J. P. Gao, Z. Y. Wang, J. Mater. Chem. 2011, 21, 1040-1048
O. Nekrassova, N. S. Lawrence, R. G. Compton, Talanta 2003, 60, 1085-1095
P. K. Sudeep, S. T. S. Joseph, K. G. Thomas, J. Am. Chem. Soc. 2005, 127, 6516-6517.
A. Zinellu, S. Sotgia, B. Scanu, M. F. Usai, A. G. Fois, V. Spada, A. Deledda, L. Deiana, P. Pirina, C. Carru, Amino Acids 2009, 37, 395-400.
A. R. Ivanov, I. V. Nazimov, L. Baratova, J. Chromatogr. A 2000, 895, 157-166
R. Hu, J. L. Maldonado, M. Rodriguez, C. Deng, C. K. W. Jim, J. W. Y. Lam, M. M. F. Yuen, G. Ramos-Ortiz, B. Z. Tang, J. Mater. Chem. 2012, 22, 232-240.
B. Mi, Y. Dong, Z. Li, J. W. Y. Lam, M. Häuβler, H. H. Y. Sung, H. S. Kwok, Y. Dong, I. D. Williams, Y. Liu, Y. Luo, Z. Shuai, D. Zhu, B. Z. Tang, Chem. Commun. 2005, 3583-3585
X. D. Zeng, X. L. Zhang, B. C. Zhu, H. Y. Jia, Y. M. Li, Dyes Pigm. 2012, 94, 10-15
W. A. Zhao, M. A. Brook, Y. F. Li, Chembiochem 2008, 9, 2363-2371
Z. Yan, S. Guang, H. Xu, X. Liu, Analyst 2011, 136, 1916-1921
S. Vallejos, P. Estevez, S. Ibeas, F. C. Garcia, F. Serna, J. M. Garcia, Sensors 2012, 12, 2969-2982
Y. Liu, C. Deng, L. Tang, A. Qin, R. Hu, J. Z. Sun, B. Z. Tang, J. Am. Chem. Soc. 2011, 133, 660-663
Y. Yu, J. Liu, Z. Zhao, K. M. Ng, K. Q. Luo, B. Z. Tang, Chem. Commun. 2012, 48, 6360-6362
M. Wen, H. Q. Liu, F. Zhang, Y. Z. Zhu, D. Liu, Y. Tian, Q. S. Wu, Chem. Commun. 2009, 4530-4532
S. Shahrokhian, Anal. Chem. 2001, 73, 5972-5978
Angew. Chem. Int. Ed. 2011, 50, 11654-11657
J. Mei, J. Wang, J. Z. Sun, H. Zhao, W. Z. Yuan, C. Deng, S. Chen, H. H. Y. Sung, P. Lu, A. Qin, H. S. Kwok, Y. Ma, I. D. Williams, B. Z. Tang, Chem. Sci. 2012, 3, 549-558
S. Seshadri, A. Beiser, J. Selhub, P. F. Jacques, I. H. Rosenberg, R. B. D′Agostino, P. W. F. Wilson, New Engl. J. Med. 2002, 346, 476-483
W. Chen, Y. Zhao, T. Seefeldt, X. M. Guan, J. Pharm. Biomed. Anal. 2008, 48, 1375-1380
Z. Yang, N. Zhao, Y. Sun, F. Miao, Y. Liu, X. Liu, Y. Zhang, W. Ai, G. Song, X. Shen, X. Yu, J. Z. Sun, W.-Y. Wong, Chem. Commun. 2012, 48, 3442-3444
H. Jiang, H. X. Ju, Anal. Chem. 2007, 79, 6690-6696
N. Y. Kwon, D. Kim, G. Jang, J. H. Lee, J. H. So, C. H. Kim, T. H. Kim, T. S. Lee, ACS Appl. Mater. Interfaces 2012, 4, 1429-1433
W. Wang, J. O. Escobedo, C. M. Lawrence, R. M. Strongin, J. Am. Chem. Soc. 2004, 126, 3400-3401
Angew. Chem. Int. Ed. 2011, 50, 10690-10693
S. Sreejith, K. P. Divya, A. Ajayaghosh, Angew. Chem. 2008, 120, 8001-8005
X. Chen, Y. Zhou, X. Peng, J. Yoon, Chem. Soc. Rev. 2010, 39, 2120-2135
M. J. MacCoss, N. K. Fukagawa, D. E. Matthews, Anal. Chem. 1999, 71, 4527-4533.
K.-S. Lee, T.-K. Kim, J. H. Lee, H.-J. Kim, J.-I. Hong, Chem. Commun. 2008, 6173-6175
L. Peng, M. Wang, G. Zhang, D. Zhang, D. Zhu, Org. Lett. 2009, 11, 1943-1946
J. Wang, J. Mei, R. Hu, J. Z. Sun, A. Qin, B. Z. Tang, J. Am. Chem. Soc. 2012, 134, 9956-9966.
A. J. Boydston, B. L. Pagenkopf, Angew. Chem. 2004, 116, 6496-6498
S. Huang, Q. Xiao, R. Li, H.-L. Guan, J. Liu, X.-R. Liu, Z.-K. He, Y. Liu, Anal. Chim. Acta 2009, 645, 73-78.
J. Chen, C. C. W. Law, J. W. Y. Lam, Y. Dong, S. M. F. Lo, I. D. Williams, D. B. Zhu, B. Z. Tang, Chem. Mater. 2003, 15, 1535-1546
J. Mei, J. Tong, J. Wang, A. Qin, J. Z. Sun, B. Z. Tang, J. Mater. Chem. 2012, 22, 17063-17070.
Z. Zhang, B. Xu, J. Su, L. Shen, Y. Xie, H. Tian, Angew. Chem. 2011, 123, 11858-11861
Y. Hong, J. W. Y. Lam, B. Z. Tang, Chem. Commun. 2009, 4332-4353
K. G. Reddie, K. S. Carroll, Curr. Opin. Chem. Biol. 2008, 12, 746-754
Y. Yu, C. Feng, Y. Hong, J. Liu, S. Chen, K. M. Ng, K. Q. Luo, B. Z. Tang, Adv. Mater. 2011, 23, 3298-3302
Z. Yao, H. Bai, C. Li, G. Shi, Chem. Commun. 2011, 47, 7431-7433
J. H. Lee, Q. D. Liu, D. R. Bai, Y. J. Kang, Y. Tao, S. N. Wang, Organometallics 2004, 23, 6205-6213
Y.-K. Yang, S. Shim, J. Tae, Chem. Commun. 2010, 46, 7766-7768
X. Yang, Y. Guo, R. M. Strongin, Angew. Chem. 2011, 123, 10878-10881
W. Zhong, Anal. Bioanal. Chem. 2009, 394, 47-59
M. Wang, G. Zhang, D. Zhang, D. Zhu, B. Z. Tang, J. Mater. Chem. 2010, 20, 1858-1867
W. Wang, L. Li, S. F. Liu, C. P. Ma, S. S. Zhang, J. Am. Chem. Soc. 2008, 130, 10846-10847
A. A. Ensafi, S. Dadkhah-Tehrani, H. karimi-Maleh, Analyti. Sci. 2011, 27, 409-414.
Y. Hong, J. W. Y. Lam, B. Z. Tang, Chem. Soc. Rev. 2011, 40, 5361-5388.
R. G. Kallen, J. Am. Chem. Soc. 1971, 93, 6236-6248.
O. Rusin, N. N. St.  Luce, R. A. Agbaria, J. O. Escobedo, S. Jiang, I. M. Warner, F. B. Dawan, K. Lian, R. M. Strongin, J. Am. Chem. Soc. 2004, 126, 438-439
J. Luo, Z. Xie, J. W. Y. Lam, L. Cheng, H. Chen, C. Qiu, H. S. Kwok, X. Zhan, Y. Liu, D. Zhu, B. Z. Tang, Chem. Commun. 2001, 1740-1741
H. S. Jung, J. H. Han, T. Pradhan, S. Kim, S. W. Lee, J. L. Sessler, T. W. Kim, C. Kang, J. S. Kim, Biomaterials 2012, 33, 945-953.
H. Refsum, P. M. Ueland, O. Nygård, S. E. Vollset, Annu. Rev. Med. 1998, 49, 31-62
J.-S. Lee, P. A. Ulmann, M. S. Han, C. A. Mirkin, Nano Lett. 2008, 8, 529-533
R. Gill, M. Zayats, I. Willner, Angew. Chem. 2008, 120, 7714-7736
C. M. Yu, F. Zeng, M. Luo, S. Z. Wu, Nanotechnology 2012, 23, 305503.
J. Mei, J. Wang, A. Qin, H. Zhao, W. Z. Yuan, Z. Zhao, H. H. Y. Sung, C. Deng, S. Zhang, I. D. Williams, J. Z. Sun, B. Z. Tang, J. Mater. Chem. 2012, 22, 4290-4298
M. Wang, D. Zhang, G. Zhang, Y. Tang, S. Wang, D. Zhu, Anal. Chem. 2008, 80, 6443-6448
W. Qin, D. Ding, J. Liu, W. Z. Yuan, Y. Hu, B. Liu, B. Z. Tang, Adv. Funct. Mater. 2012, 22, 771-779
1998; 49
2004; 126
2009; 81
2000; 895
2010; 468
2004; 28
2004; 23
2008; 9
2011; 52
2003; 15
2008; 8
2011 2011; 123 50
2009; 394
2012; 12
2007; 79
2009; 11
2010; 20
1971; 93
2012; 134
2001
2002; 346
2011; 21
2011; 23
2011; 27
2012; 23
2012; 22
2009; 645
2011; 136
2004 2004; 116 43
2010; 39
2011; 40
2009
2008
2008; 12
2005
2004
2012; 33
2011; 133
2012; 94
2009; 1216
2012; 3
2010; 46
2005; 402
2005; 127
2008; 48
2012; 48
2011; 47
2005; 15
2003; 60
1999; 71
2012; 4
2008 2008; 120 47
2001; 73
2008; 130
2008; 80
2009; 37
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References_xml – volume: 468
  start-page: 790
  year: 2010
  end-page: 795
  publication-title: Nature
– volume: 1216
  start-page: 3874
  year: 2009
  end-page: 3880
  publication-title: J. Chromatogr. A
– volume: 48
  start-page: 1375
  year: 2008
  end-page: 1380
  publication-title: J. Pharm. Biomed. Anal.
– start-page: 1762
  year: 2004
  end-page: 1763
  publication-title: Chem. Commun.
– volume: 120 47
  start-page: 8001 7883
  year: 2008 2008
  end-page: 8005 7887
  publication-title: Angew. Chem. Angew. Chem. Int. Ed.
– volume: 94
  start-page: 10
  year: 2012
  end-page: 15
  publication-title: Dyes Pigm.
– volume: 12
  start-page: 746
  year: 2008
  end-page: 754
  publication-title: Curr. Opin. Chem. Biol.
– volume: 73
  start-page: 5972
  year: 2001
  end-page: 5978
  publication-title: Anal. Chem.
– volume: 23
  start-page: 6205
  year: 2004
  end-page: 6213
  publication-title: Organometallics
– volume: 22
  start-page: 771
  year: 2012
  end-page: 779
  publication-title: Adv. Funct. Mater.
– start-page: 4332
  year: 2009
  end-page: 4353
  publication-title: Chem. Commun.
– volume: 21
  start-page: 1040
  year: 2011
  end-page: 1048
  publication-title: J. Mater. Chem.
– volume: 48
  start-page: 6360
  year: 2012
  end-page: 6362
  publication-title: Chem. Commun.
– volume: 126
  start-page: 438
  year: 2004
  end-page: 439
  publication-title: J. Am. Chem. Soc.
– volume: 23
  start-page: 3298
  year: 2011
  end-page: 3302
  publication-title: Adv. Mater.
– volume: 23
  start-page: 305503
  year: 2012
  publication-title: Nanotechnology
– volume: 37
  start-page: 395
  year: 2009
  end-page: 400
  publication-title: Amino Acids
– volume: 12
  start-page: 2969
  year: 2012
  end-page: 2982
  publication-title: Sensors
– volume: 22
  start-page: 15128
  year: 2012
  end-page: 15135
  publication-title: J. Mater. Chem.
– volume: 60
  start-page: 1229
  year: 2003
  end-page: 1238
  publication-title: Talanta
– volume: 33
  start-page: 945
  year: 2012
  end-page: 953
  publication-title: Biomaterials
– volume: 71
  start-page: 4527
  year: 1999
  end-page: 4533
  publication-title: Anal. Chem.
– volume: 93
  start-page: 6236
  year: 1971
  end-page: 6248
  publication-title: J. Am. Chem. Soc.
– volume: 127
  start-page: 6516
  year: 2005
  end-page: 6517
  publication-title: J. Am. Chem. Soc.
– volume: 22
  start-page: 232
  year: 2012
  end-page: 240
  publication-title: J. Mater. Chem.
– volume: 39
  start-page: 2120
  year: 2010
  end-page: 2135
  publication-title: Chem. Soc. Rev.
– volume: 22
  start-page: 4290
  year: 2012
  end-page: 4298
  publication-title: J. Mater. Chem.
– volume: 52
  start-page: 1422
  year: 2011
  end-page: 1425
  publication-title: Tetrahedron Lett.
– volume: 4
  start-page: 1429
  year: 2012
  end-page: 1433
  publication-title: ACS Appl. Mater. Interfaces
– volume: 80
  start-page: 6443
  year: 2008
  end-page: 6448
  publication-title: Anal. Chem.
– volume: 895
  start-page: 157
  year: 2000
  end-page: 166
  publication-title: J. Chromatogr. A
– start-page: 6173
  year: 2008
  end-page: 6175
  publication-title: Chem. Commun.
– volume: 28
  start-page: 1086
  year: 2004
  end-page: 1090
  publication-title: New J. Chem.
– volume: 60
  start-page: 1085
  year: 2003
  end-page: 1095
  publication-title: Talanta
– volume: 46
  start-page: 7766
  year: 2010
  end-page: 7768
  publication-title: Chem. Commun.
– volume: 402
  start-page: 468
  year: 2005
  end-page: 473
  publication-title: Chem. Phys. Lett.
– volume: 394
  start-page: 47
  year: 2009
  end-page: 59
  publication-title: Anal. Bioanal. Chem.
– volume: 81
  start-page: 4444
  year: 2009
  end-page: 4449
  publication-title: Anal. Chem.
– volume: 15
  start-page: 1535
  year: 2003
  end-page: 1546
  publication-title: Chem. Mater.
– volume: 123 50
  start-page: 10878 10690
  year: 2011 2011
  end-page: 10881 10693
  publication-title: Angew. Chem. Angew. Chem. Int. Ed.
– volume: 22
  start-page: 17063
  year: 2012
  end-page: 17070
  publication-title: J. Mater. Chem.
– volume: 20
  start-page: 1858
  year: 2010
  end-page: 1867
  publication-title: J. Mater. Chem.
– volume: 346
  start-page: 476
  year: 2002
  end-page: 483
  publication-title: New Engl. J. Med.
– volume: 645
  start-page: 73
  year: 2009
  end-page: 78
  publication-title: Anal. Chim. Acta
– volume: 134
  start-page: 9956
  year: 2012
  end-page: 9966
  publication-title: J. Am. Chem. Soc.
– volume: 3
  start-page: 549
  year: 2012
  end-page: 558
  publication-title: Chem. Sci.
– volume: 48
  start-page: 3442
  year: 2012
  end-page: 3444
  publication-title: Chem. Commun.
– volume: 133
  start-page: 660
  year: 2011
  end-page: 663
  publication-title: J. Am. Chem. Soc.
– volume: 123 50
  start-page: 11858 11654
  year: 2011 2011
  end-page: 11861 11657
  publication-title: Angew. Chem. Angew. Chem. Int. Ed.
– volume: 136
  start-page: 1916
  year: 2011
  end-page: 1921
  publication-title: Analyst
– volume: 134
  start-page: 9569
  year: 2012
  end-page: 9572
  publication-title: J. Am. Chem. Soc.
– volume: 116 43
  start-page: 6496 6336
  year: 2004 2004
  end-page: 6498 6338
  publication-title: Angew. Chem. Angew. Chem. Int. Ed.
– volume: 126
  start-page: 4064
  year: 2004
  end-page: 4065
  publication-title: J. Am. Chem. Soc.
– start-page: 4530
  year: 2009
  end-page: 4532
  publication-title: Chem. Commun.
– volume: 27
  start-page: 409
  year: 2011
  end-page: 414
  publication-title: Analyti. Sci.
– volume: 15
  start-page: 287
  year: 2005
  end-page: 291
  publication-title: J. Inorg. Organomet. Polym. Mater.
– volume: 9
  start-page: 2363
  year: 2008
  end-page: 2371
  publication-title: Chembiochem
– start-page: 1740
  year: 2001
  end-page: 1741
  publication-title: Chem. Commun.
– volume: 8
  start-page: 529
  year: 2008
  end-page: 533
  publication-title: Nano Lett.
– volume: 126
  start-page: 3400
  year: 2004
  end-page: 3401
  publication-title: J. Am. Chem. Soc.
– volume: 11
  start-page: 1943
  year: 2009
  end-page: 1946
  publication-title: Org. Lett.
– start-page: 3583
  year: 2005
  end-page: 3585
  publication-title: Chem. Commun.
– volume: 49
  start-page: 31
  year: 1998
  end-page: 62
  publication-title: Annu. Rev. Med.
– volume: 47
  start-page: 7431
  year: 2011
  end-page: 7433
  publication-title: Chem. Commun.
– volume: 3
  start-page: 1049
  year: 2012
  end-page: 1061
  publication-title: Chem. Sci.
– volume: 120 47
  start-page: 7714 7602
  year: 2008 2008
  end-page: 7736 7625
  publication-title: Angew. Chem. Angew. Chem. Int. Ed.
– volume: 79
  start-page: 6690
  year: 2007
  end-page: 6696
  publication-title: Anal. Chem.
– volume: 40
  start-page: 5361
  year: 2011
  end-page: 5388
  publication-title: Chem. Soc. Rev.
– volume: 46
  start-page: 4938
  year: 2010
  end-page: 4940
  publication-title: Chem. Commun.
– volume: 130
  start-page: 10846
  year: 2008
  end-page: 10847
  publication-title: J. Am. Chem. Soc.
– ident: e_1_2_6_56_2
  doi: 10.1021/am201677r
– ident: e_1_2_6_58_2
– ident: e_1_2_6_51_2
  doi: 10.1021/ja0318838
– ident: e_1_2_6_16_2
  doi: 10.1021/ja208883h
– ident: e_1_2_6_37_2
  doi: 10.1016/j.chroma.2009.02.083
– ident: e_1_2_6_69_2
  doi: 10.3390/s120302969
– ident: e_1_2_6_10_3
  doi: 10.1002/anie.200461844
– ident: e_1_2_6_18_2
  doi: 10.1021/ac801020v
– ident: e_1_2_6_74_2
– ident: e_1_2_6_62_2
  doi: 10.1002/ange.200803194
– ident: e_1_2_6_54_2
  doi: 10.1016/j.tetlet.2010.07.182
– ident: e_1_2_6_75_2
  doi: 10.1039/c1jm12673c
– ident: e_1_2_6_64_2
  doi: 10.1039/c0cc02381g
– ident: e_1_2_6_65_2
  doi: 10.1039/C0JM02497J
– ident: e_1_2_6_34_2
  doi: 10.1016/S0039-9140(03)00232-7
– ident: e_1_2_6_4_2
  doi: 10.1039/c1cs15113d
– ident: e_1_2_6_20_2
  doi: 10.1021/ja107086y
– ident: e_1_2_6_27_2
  doi: 10.1146/annurev.med.49.1.31
– ident: e_1_2_6_45_2
  doi: 10.1002/cbic.200800282
– ident: e_1_2_6_39_2
  doi: 10.1007/s00726-008-0167-x
– ident: e_1_2_6_49_2
  doi: 10.1016/j.aca.2009.04.034
– ident: e_1_2_6_7_2
  doi: 10.1007/s10904-005-5546-0
– ident: e_1_2_6_46_2
  doi: 10.1002/ange.200800169
– ident: e_1_2_6_77_2
  doi: 10.1039/c2jm32892e
– ident: e_1_2_6_11_2
  doi: 10.1039/b405238b
– ident: e_1_2_6_24_2
  doi: 10.1039/c2jm31368e
– ident: e_1_2_6_72_2
  doi: 10.1002/ange.201103759
– ident: e_1_2_6_19_2
  doi: 10.1021/ac9002722
– ident: e_1_2_6_73_2
  doi: 10.1088/0957-4484/23/30/305503
– ident: e_1_2_6_12_2
  doi: 10.1016/j.cplett.2004.12.103
– ident: e_1_2_6_78_2
  doi: 10.1021/ja00752a040
– ident: e_1_2_6_52_2
  doi: 10.1021/ja031987i
– ident: e_1_2_6_76_2
  doi: 10.1039/C1SC00688F
– ident: e_1_2_6_2_2
  doi: 10.1039/b904665h
– ident: e_1_2_6_61_2
  doi: 10.1039/b814581d
– ident: e_1_2_6_71_2
– ident: e_1_2_6_79_2
  doi: 10.1039/C1JM13556B
– ident: e_1_2_6_28_2
  doi: 10.1021/ac010541m
– ident: e_1_2_6_68_2
  doi: 10.1039/c2cc00093h
– ident: e_1_2_6_48_2
  doi: 10.1007/s00216-009-2643-x
– ident: e_1_2_6_72_3
  doi: 10.1002/anie.201103759
– ident: e_1_2_6_17_2
– ident: e_1_2_6_66_2
  doi: 10.1039/c1cc11990g
– ident: e_1_2_6_10_2
  doi: 10.1002/ange.200461844
– ident: e_1_2_6_38_2
  doi: 10.1021/ac990541a
– ident: e_1_2_6_6_2
  doi: 10.1039/b105159h
– ident: e_1_2_6_5_2
– ident: e_1_2_6_63_2
  doi: 10.1039/c0cc00630k
– ident: e_1_2_6_25_2
  doi: 10.1021/ja302369e
– ident: e_1_2_6_41_2
  doi: 10.1021/ja802273p
– ident: e_1_2_6_15_3
  doi: 10.1002/anie.201104533
– ident: e_1_2_6_35_2
  doi: 10.1016/S0039-9140(03)00173-5
– ident: e_1_2_6_70_2
  doi: 10.1039/c2sc00762b
– ident: e_1_2_6_50_2
– ident: e_1_2_6_14_2
  doi: 10.1021/ol900376r
– ident: e_1_2_6_23_2
  doi: 10.1002/adfm.201102191
– ident: e_1_2_6_36_2
  doi: 10.1016/j.jpba.2008.08.033
– ident: e_1_2_6_32_2
– ident: e_1_2_6_29_2
  doi: 10.1056/NEJMoa011613
– ident: e_1_2_6_40_2
  doi: 10.1021/ac071061j
– ident: e_1_2_6_46_3
  doi: 10.1002/anie.200800169
– ident: e_1_2_6_9_2
  doi: 10.1021/om0494216
– ident: e_1_2_6_15_2
  doi: 10.1002/ange.201104533
– ident: e_1_2_6_30_2
  doi: 10.1016/j.cbpa.2008.07.028
– ident: e_1_2_6_47_2
  doi: 10.1021/nl0727563
– ident: e_1_2_6_57_2
  doi: 10.1016/j.biomaterials.2011.10.040
– ident: e_1_2_6_21_2
  doi: 10.1002/adma.201101714
– ident: e_1_2_6_44_2
  doi: 10.1021/ja051145e
– ident: e_1_2_6_67_2
  doi: 10.1016/j.dyepig.2011.10.013
– ident: e_1_2_6_26_2
– ident: e_1_2_6_33_2
  doi: 10.1016/S0021-9673(00)00713-5
– ident: e_1_2_6_42_2
  doi: 10.1039/b907379e
– ident: e_1_2_6_55_2
  doi: 10.1039/c0an00943a
– ident: e_1_2_6_3_2
  doi: 10.1039/b921610c
– ident: e_1_2_6_8_2
  doi: 10.1021/cm021715z
– ident: e_1_2_6_59_2
  doi: 10.1039/b405642f
– ident: e_1_2_6_22_2
  doi: 10.1039/c2cc32038j
– ident: e_1_2_6_53_2
  doi: 10.1039/b925092a
– ident: e_1_2_6_1_2
– ident: e_1_2_6_13_2
  doi: 10.1039/b505683g
– ident: e_1_2_6_31_2
  doi: 10.1038/nature09472
– ident: e_1_2_6_60_2
  doi: 10.1021/ja036297t
– ident: e_1_2_6_62_3
  doi: 10.1002/anie.200803194
– ident: e_1_2_6_43_2
  doi: 10.2116/analsci.27.409
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Snippet We demonstrate a concept‐proof work of using fluorescence (FL) “turn‐on” probes for the discriminatory detection of cysteine (Cys) over homocysteine (Hcy). The...
We demonstrate a concept-proof work of using fluorescence (FL) "turn-on" probes for the discriminatory detection of cysteine (Cys) over homocysteine (Hcy). The...
Abstract We demonstrate a concept‐proof work of using fluorescence (FL) “turn‐on” probes for the discriminatory detection of cysteine (Cys) over homocysteine...
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SubjectTerms aggregation
Aldehydes
Aldehydes - chemistry
Amino acids
Buffers
Chemistry
Chemistry Techniques, Analytical - instrumentation
Cysteine
Cysteine - analysis
Cysteine - blood
Cysteine - chemistry
Dimethyl Sulfoxide - chemistry
Discrimination
Emission
Fluorescence
fluorescence spectroscopy
Fluorescent Dyes - chemistry
fluorescent probes
Homocysteine
Homocysteine - analysis
Homocysteine - blood
Homocysteine - chemistry
Humans
Isomerism
Reaction kinetics
Solubility
Spectrometry, Fluorescence
Title Discriminatory Detection of Cysteine and Homocysteine Based on Dialdehyde-Functionalized Aggregation-Induced Emission Fluorophores
URI https://api.istex.fr/ark:/67375/WNG-8D4ZVH6M-D/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fchem.201202969
https://www.ncbi.nlm.nih.gov/pubmed/23193021
https://www.proquest.com/docview/1266113513
https://search.proquest.com/docview/1273118007
https://search.proquest.com/docview/1778010110
Volume 19
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