Selegiline improves excessive daytime sleepiness in Parkinson's disease: an open-label observational study

Changes from baseline to Week 3 and Week 8 in ESS, Parkinson's Disease Sleep Scale (PDSS), and Parkinson's Disease Quality of Life Questionnaire 39 (PDQ-39) assessments were analyzed using mixed-effect models (repeated quantitative data, and abnormal distribution). Selegiline has been show...

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Published inChinese medical journal Vol. 135; no. 14; pp. 1762 - 1764
Main Authors Zhang, Jinru, Chen, Juping, Li, Jia, Li, Jian, Miao, Hong, Zhu, Xiangyang, Meng, Meng, Han, Yang, Chen, Jing, Cheng, Xiaoyu, Xiong, Kangping, Jin, Hong, Luo, Weifeng, Mao, Chengjie, Liu, Chunfeng
Format Journal Article
LanguageEnglish
Published China Lippincott Williams & Wilkins 20.07.2022
Lippincott Williams & Wilkins Ovid Technologies
Wolters Kluwer
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Online AccessGet full text
ISSN0366-6999
2542-5641
2542-5641
DOI10.1097/CM9.0000000000002308

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Abstract Changes from baseline to Week 3 and Week 8 in ESS, Parkinson's Disease Sleep Scale (PDSS), and Parkinson's Disease Quality of Life Questionnaire 39 (PDQ-39) assessments were analyzed using mixed-effect models (repeated quantitative data, and abnormal distribution). Selegiline has been shown to improve motor symptoms, but other effects were not investigated. Since EDS in patients with PD does not typically respond to dopaminergic therapy, selegiline may be effective in treating this condition. [...]we assessed EDS and sleep quality by ESS and PDSS, not by polysomnography. [...]since selegiline has achieved good results in improving motor symptoms for PD patients,[3,4] we did not assess the motor symptoms, including Unified Parkinson Disease Rating Scale Part III; therefore, the sleep benefits may have resulted from improved motor symptoms.
AbstractList Changes from baseline to Week 3 and Week 8 in ESS, Parkinson's Disease Sleep Scale (PDSS), and Parkinson's Disease Quality of Life Questionnaire 39 (PDQ-39) assessments were analyzed using mixed-effect models (repeated quantitative data, and abnormal distribution). Selegiline has been shown to improve motor symptoms, but other effects were not investigated. Since EDS in patients with PD does not typically respond to dopaminergic therapy, selegiline may be effective in treating this condition. [...]we assessed EDS and sleep quality by ESS and PDSS, not by polysomnography. [...]since selegiline has achieved good results in improving motor symptoms for PD patients,[3,4] we did not assess the motor symptoms, including Unified Parkinson Disease Rating Scale Part III; therefore, the sleep benefits may have resulted from improved motor symptoms.
Author Meng, Meng
Mao, Chengjie
Jin, Hong
Han, Yang
Cheng, Xiaoyu
Luo, Weifeng
Xiong, Kangping
Zhang, Jinru
Chen, Juping
Li, Jia
Liu, Chunfeng
Miao, Hong
Zhu, Xiangyang
Li, Jian
Chen, Jing
AuthorAffiliation Department of Neurology, JiangYuan Hospital Affiliated to Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu 214063, China
Department of Neurology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China
Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu 215123, China
Department of Neurology, Changshu Hospital Affiliated to Nanjing University of Chinese Medicine, Changshu, Jiangsu 215516, China
Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China
AuthorAffiliation_xml – name: Department of Neurology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China
– name: Department of Neurology, Changshu Hospital Affiliated to Nanjing University of Chinese Medicine, Changshu, Jiangsu 215516, China
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– name: Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China
– name: Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu 215123, China
– name: 2 Department of Neurology, Changshu Hospital Affiliated to Nanjing University of Chinese Medicine, Changshu, Jiangsu 215516, China
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  organization: Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu 215123, China
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CitedBy_id crossref_primary_10_1080_14656566_2024_2422004
crossref_primary_10_1016_S0140_6736_23_01429_0
crossref_primary_10_3389_frsle_2023_1302021
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Snippet Changes from baseline to Week 3 and Week 8 in ESS, Parkinson's Disease Sleep Scale (PDSS), and Parkinson's Disease Quality of Life Questionnaire 39 (PDQ-39)...
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StartPage 1762
SubjectTerms Activities of daily living
Clinical trials
Correspondence
Disorders of Excessive Somnolence
Dopamine
Drug dosages
Dyskinesia
Humans
Insomnia
Nocturia
Observational studies
Parkinson Disease - drug therapy
Parkinson's disease
Psychosis
Quality of life
Questionnaires
Restless legs syndrome
Selegiline - therapeutic use
Severity of Illness Index
Sleep
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Title Selegiline improves excessive daytime sleepiness in Parkinson's disease: an open-label observational study
URI https://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00029330-202207200-00019
https://www.ncbi.nlm.nih.gov/pubmed/35946804
https://www.proquest.com/docview/2720852478
https://www.proquest.com/docview/2700639604
https://pubmed.ncbi.nlm.nih.gov/PMC9509153
https://doaj.org/article/ed58eb7ab98d4496b1d5f7bf95b2f79f
Volume 135
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