Selegiline improves excessive daytime sleepiness in Parkinson's disease: an open-label observational study
Changes from baseline to Week 3 and Week 8 in ESS, Parkinson's Disease Sleep Scale (PDSS), and Parkinson's Disease Quality of Life Questionnaire 39 (PDQ-39) assessments were analyzed using mixed-effect models (repeated quantitative data, and abnormal distribution). Selegiline has been show...
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Published in | Chinese medical journal Vol. 135; no. 14; pp. 1762 - 1764 |
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Main Authors | , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
China
Lippincott Williams & Wilkins
20.07.2022
Lippincott Williams & Wilkins Ovid Technologies Wolters Kluwer |
Subjects | |
Online Access | Get full text |
ISSN | 0366-6999 2542-5641 2542-5641 |
DOI | 10.1097/CM9.0000000000002308 |
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Abstract | Changes from baseline to Week 3 and Week 8 in ESS, Parkinson's Disease Sleep Scale (PDSS), and Parkinson's Disease Quality of Life Questionnaire 39 (PDQ-39) assessments were analyzed using mixed-effect models (repeated quantitative data, and abnormal distribution). Selegiline has been shown to improve motor symptoms, but other effects were not investigated. Since EDS in patients with PD does not typically respond to dopaminergic therapy, selegiline may be effective in treating this condition. [...]we assessed EDS and sleep quality by ESS and PDSS, not by polysomnography. [...]since selegiline has achieved good results in improving motor symptoms for PD patients,[3,4] we did not assess the motor symptoms, including Unified Parkinson Disease Rating Scale Part III; therefore, the sleep benefits may have resulted from improved motor symptoms. |
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AbstractList | Changes from baseline to Week 3 and Week 8 in ESS, Parkinson's Disease Sleep Scale (PDSS), and Parkinson's Disease Quality of Life Questionnaire 39 (PDQ-39) assessments were analyzed using mixed-effect models (repeated quantitative data, and abnormal distribution). Selegiline has been shown to improve motor symptoms, but other effects were not investigated. Since EDS in patients with PD does not typically respond to dopaminergic therapy, selegiline may be effective in treating this condition. [...]we assessed EDS and sleep quality by ESS and PDSS, not by polysomnography. [...]since selegiline has achieved good results in improving motor symptoms for PD patients,[3,4] we did not assess the motor symptoms, including Unified Parkinson Disease Rating Scale Part III; therefore, the sleep benefits may have resulted from improved motor symptoms. |
Author | Meng, Meng Mao, Chengjie Jin, Hong Han, Yang Cheng, Xiaoyu Luo, Weifeng Xiong, Kangping Zhang, Jinru Chen, Juping Li, Jia Liu, Chunfeng Miao, Hong Zhu, Xiangyang Li, Jian Chen, Jing |
AuthorAffiliation | Department of Neurology, JiangYuan Hospital Affiliated to Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu 214063, China Department of Neurology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu 215123, China Department of Neurology, Changshu Hospital Affiliated to Nanjing University of Chinese Medicine, Changshu, Jiangsu 215516, China Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China |
AuthorAffiliation_xml | – name: Department of Neurology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China – name: Department of Neurology, Changshu Hospital Affiliated to Nanjing University of Chinese Medicine, Changshu, Jiangsu 215516, China – name: Department of Neurology, JiangYuan Hospital Affiliated to Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu 214063, China – name: Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China – name: Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu 215123, China – name: 2 Department of Neurology, Changshu Hospital Affiliated to Nanjing University of Chinese Medicine, Changshu, Jiangsu 215516, China – name: 5 Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu 215123, China – name: 1 Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China – name: 3 Department of Neurology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China – name: 4 Department of Neurology, JiangYuan Hospital Affiliated to Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu 214063, China |
Author_xml | – sequence: 1 givenname: Jinru surname: Zhang fullname: Zhang, Jinru organization: Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China – sequence: 2 givenname: Juping surname: Chen fullname: Chen, Juping organization: Department of Neurology, Changshu Hospital Affiliated to Nanjing University of Chinese Medicine, Changshu, Jiangsu 215516, China – sequence: 3 givenname: Jia surname: Li fullname: Li, Jia organization: Department of Neurology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China – sequence: 4 givenname: Jian surname: Li fullname: Li, Jian organization: Department of Neurology, JiangYuan Hospital Affiliated to Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu 214063, China – sequence: 5 givenname: Hong surname: Miao fullname: Miao, Hong organization: Department of Neurology, Changshu Hospital Affiliated to Nanjing University of Chinese Medicine, Changshu, Jiangsu 215516, China – sequence: 6 givenname: Xiangyang surname: Zhu fullname: Zhu, Xiangyang organization: Department of Neurology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China – sequence: 7 givenname: Meng surname: Meng fullname: Meng, Meng organization: Department of Neurology, JiangYuan Hospital Affiliated to Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu 214063, China – sequence: 8 givenname: Yang surname: Han fullname: Han, Yang organization: Department of Neurology, Changshu Hospital Affiliated to Nanjing University of Chinese Medicine, Changshu, Jiangsu 215516, China – sequence: 9 givenname: Jing surname: Chen fullname: Chen, Jing organization: Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China – sequence: 10 givenname: Xiaoyu surname: Cheng fullname: Cheng, Xiaoyu organization: Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China – sequence: 11 givenname: Kangping surname: Xiong fullname: Xiong, Kangping organization: Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China – sequence: 12 givenname: Hong surname: Jin fullname: Jin, Hong organization: Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China – sequence: 13 givenname: Weifeng surname: Luo fullname: Luo, Weifeng organization: Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China – sequence: 14 givenname: Chengjie surname: Mao fullname: Mao, Chengjie organization: Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China – sequence: 15 givenname: Chunfeng surname: Liu fullname: Liu, Chunfeng organization: Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu 215123, China |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35946804$$D View this record in MEDLINE/PubMed |
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CitedBy_id | crossref_primary_10_1080_14656566_2024_2422004 crossref_primary_10_1016_S0140_6736_23_01429_0 crossref_primary_10_3389_frsle_2023_1302021 |
Cites_doi | 10.1007/s10072-003-0118-y 10.1002/1531-8257(200003)15:2<212::AID-MDS1002>3.0.CO;2-6 10.1097/WNF.0000000000000239 10.1111/j.1468-1331.2006.01262.x 10.1371/journal.pone.0205100 10.5152/npa.2015.7359 10.1093/sleep/zsz004 10.1212/WNL.57.8.1392 10.1093/sleep/10.5.491 10.1212/WNL.44.11.2095 10.1097/CM9.0000000000001303 10.1136/jnnp.73.6.629 10.1016/j.parkreldis.2012.08.003 |
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Snippet | Changes from baseline to Week 3 and Week 8 in ESS, Parkinson's Disease Sleep Scale (PDSS), and Parkinson's Disease Quality of Life Questionnaire 39 (PDQ-39)... |
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SubjectTerms | Activities of daily living Clinical trials Correspondence Disorders of Excessive Somnolence Dopamine Drug dosages Dyskinesia Humans Insomnia Nocturia Observational studies Parkinson Disease - drug therapy Parkinson's disease Psychosis Quality of life Questionnaires Restless legs syndrome Selegiline - therapeutic use Severity of Illness Index Sleep |
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Title | Selegiline improves excessive daytime sleepiness in Parkinson's disease: an open-label observational study |
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