Concurrent Block Copolymer Polymersome Stabilization and Bilayer Permeabilization by Stimuli-Regulated "Traceless" Crosslinking

• Published in: Angewandte Chemie International Edition Vol. 53; no. 12; pp. 3138 - 3142
• Main Authors: Wang, Xiaorui, Liu, Guhuan, Hu, Jinming, Zhang, Guoying, Liu, Shiyong
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 17.03.2014; WILEY‐VCH Verlag; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Amines; Block copolymers; Copolymers; Covalence; Crosslinking; Fabrication; Membranes; Molecular Structure; permeability; Polymers - chemistry; polymersomes; self-assembly; Solubility; Stabilization; Strategy; Vesicles; Water - chemistry; block copolymers; self-assembly; crosslinking; polymersomes; permeability

The fabrication of block copolymer (BCP) vesicles (polymersomes) exhibiting synchronized covalent crosslinking and bilayer permeabilization remains a considerable challenge as crosslinking typically leads to compromised membrane permeability. Herein it is demonstrated how to solve this dilemma by em...