Mathematical modelling of the diurnal regulation of the MEP pathway in Arabidopsis

Isoprenoid molecules are essential elements of plant metabolism. Many important plant isoprenoids, such as chlorophylls, carotenoids, tocopherols, prenylated quinones and hormones are synthesised in chloroplasts via the 2‐C‐methyl‐d‐erythritol 4‐phosphate (MEP) pathway. Here we develop a mathematica...

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Published inThe New phytologist Vol. 206; no. 3; pp. 1075 - 1085
Main Authors Pokhilko, Alexandra, Bou‐Torrent, Jordi, Pulido, Pablo, Rodríguez‐Concepción, Manuel, Ebenhöh, Oliver
Format Journal Article
LanguageEnglish
Published England Academic Press 01.05.2015
New Phytologist Trust
Wiley Subscription Services, Inc
Subjects
2‐C‐methyl‐D‐erythritol 4‐phosphate (MEP) pathway
Arabidopsis - metabolism
Arabidopsis - radiation effects
Arabidopsis thaliana
Biological clocks
Carotenoids
Chlorophyll
Chloroplasts
Circadian Clocks
Circadian Rhythm
Circadian rhythms
Diurnal
Erythritol
Erythritol - analogs & derivatives
Erythritol - metabolism
Feedback
Feedback control
Fluctuations
Flux
Gene regulation
genes
Growth conditions
Hormones
isoprenoids
Mathematical analysis
mathematical modelling
Mathematical models
Metabolic Networks and Pathways
Model testing
Models, Biological
Phosphates
Photosynthesis
Plant metabolism
Quinones
Substrates
Sugar Phosphates - metabolism
systems biology
Terpenes
Tocopherols
Transcription
transcription (genetics)
whole plant physiology
Xylulose
Arabidopsis thaliana
systems biology
mathematical modelling
isoprenoids
2-C-methyl-D-erythritol 4-phosphate (MEP) pathway
whole plant physiology
plant metabolism
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Abstract Isoprenoid molecules are essential elements of plant metabolism. Many important plant isoprenoids, such as chlorophylls, carotenoids, tocopherols, prenylated quinones and hormones are synthesised in chloroplasts via the 2‐C‐methyl‐d‐erythritol 4‐phosphate (MEP) pathway. Here we develop a mathematical model of diurnal regulation of the MEP pathway in Arabidopsis thaliana. We used both experimental and theoretical approaches to integrate mechanisms potentially involved in the diurnal control of the pathway. Our data show that flux through the MEP pathway is accelerated in light due to the photosynthesis‐dependent supply of metabolic substrates of the pathway and the transcriptional regulation of key biosynthetic genes by the circadian clock. We also demonstrate that feedback regulation of both the activity and the abundance of the first enzyme of the MEP pathway (1‐deoxy‐d‐xylulose 5‐phosphate synthase, DXS) by pathway products stabilizes the flux against changes in substrate supply and adjusts the flux according to product demand under normal growth conditions. These data illustrate the central relevance of photosynthesis, the circadian clock and feedback control of DXS for the diurnal regulation of the MEP pathway.
AbstractList Isoprenoid molecules are essential elements of plant metabolism. Many important plant isoprenoids, such as chlorophylls, carotenoids, tocopherols, prenylated quinones and hormones are synthesised in chloroplasts via the 2‐C‐methyl‐d‐erythritol 4‐phosphate (MEP) pathway. Here we develop a mathematical model of diurnal regulation of the MEP pathway in Arabidopsis thaliana. We used both experimental and theoretical approaches to integrate mechanisms potentially involved in the diurnal control of the pathway. Our data show that flux through the MEP pathway is accelerated in light due to the photosynthesis‐dependent supply of metabolic substrates of the pathway and the transcriptional regulation of key biosynthetic genes by the circadian clock. We also demonstrate that feedback regulation of both the activity and the abundance of the first enzyme of the MEP pathway (1‐deoxy‐d‐xylulose 5‐phosphate synthase, DXS) by pathway products stabilizes the flux against changes in substrate supply and adjusts the flux according to product demand under normal growth conditions. These data illustrate the central relevance of photosynthesis, the circadian clock and feedback control of DXS for the diurnal regulation of the MEP pathway.
Isoprenoid molecules are essential elements of plant metabolism. Many important plant isoprenoids, such as chlorophylls, carotenoids, tocopherols, prenylated quinones and hormones are synthesised in chloroplasts via the 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway. Here we develop a mathematical model of diurnal regulation of the MEP pathway in Arabidopsis thaliana. We used both experimental and theoretical approaches to integrate mechanisms potentially involved in the diurnal control of the pathway. Our data show that flux through the MEP pathway is accelerated in light due to the photosynthesis-dependent supply of metabolic substrates of the pathway and the transcriptional regulation of key biosynthetic genes by the circadian clock. We also demonstrate that feedback regulation of both the activity and the abundance of the first enzyme of the MEP pathway (1-deoxy-d-xylulose 5-phosphate synthase, DXS) by pathway products stabilizes the flux against changes in substrate supply and adjusts the flux according to product demand under normal growth conditions. These data illustrate the central relevance of photosynthesis, the circadian clock and feedback control of DXS for the diurnal regulation of the MEP pathway.
Summary Isoprenoid molecules are essential elements of plant metabolism. Many important plant isoprenoids, such as chlorophylls, carotenoids, tocopherols, prenylated quinones and hormones are synthesised in chloroplasts via the 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway. Here we develop a mathematical model of diurnal regulation of the MEP pathway in Arabidopsis thaliana. We used both experimental and theoretical approaches to integrate mechanisms potentially involved in the diurnal control of the pathway. Our data show that flux through the MEP pathway is accelerated in light due to the photosynthesis-dependent supply of metabolic substrates of the pathway and the transcriptional regulation of key biosynthetic genes by the circadian clock. We also demonstrate that feedback regulation of both the activity and the abundance of the first enzyme of the MEP pathway (1-deoxy-d-xylulose 5-phosphate synthase, DXS) by pathway products stabilizes the flux against changes in substrate supply and adjusts the flux according to product demand under normal growth conditions. These data illustrate the central relevance of photosynthesis, the circadian clock and feedback control of DXS for the diurnal regulation of the MEP pathway.
Isoprenoid molecules are essential elements of plant metabolism. Many important plant isoprenoids, such as chlorophylls, carotenoids, tocopherols, prenylated quinones and hormones are synthesised in chloroplasts via the 2‐ C ‐methyl‐ d ‐erythritol 4‐phosphate ( MEP ) pathway. Here we develop a mathematical model of diurnal regulation of the MEP pathway in Arabidopsis thaliana . We used both experimental and theoretical approaches to integrate mechanisms potentially involved in the diurnal control of the pathway. Our data show that flux through the MEP pathway is accelerated in light due to the photosynthesis‐dependent supply of metabolic substrates of the pathway and the transcriptional regulation of key biosynthetic genes by the circadian clock. We also demonstrate that feedback regulation of both the activity and the abundance of the first enzyme of the MEP pathway (1‐deoxy‐ d ‐xylulose 5‐phosphate synthase, DXS ) by pathway products stabilizes the flux against changes in substrate supply and adjusts the flux according to product demand under normal growth conditions. These data illustrate the central relevance of photosynthesis, the circadian clock and feedback control of DXS for the diurnal regulation of the MEP pathway.
Summary Isoprenoid molecules are essential elements of plant metabolism. Many important plant isoprenoids, such as chlorophylls, carotenoids, tocopherols, prenylated quinones and hormones are synthesised in chloroplasts via the 2‐C‐methyl‐d‐erythritol 4‐phosphate (MEP) pathway. Here we develop a mathematical model of diurnal regulation of the MEP pathway in Arabidopsis thaliana. We used both experimental and theoretical approaches to integrate mechanisms potentially involved in the diurnal control of the pathway. Our data show that flux through the MEP pathway is accelerated in light due to the photosynthesis‐dependent supply of metabolic substrates of the pathway and the transcriptional regulation of key biosynthetic genes by the circadian clock. We also demonstrate that feedback regulation of both the activity and the abundance of the first enzyme of the MEP pathway (1‐deoxy‐d‐xylulose 5‐phosphate synthase, DXS) by pathway products stabilizes the flux against changes in substrate supply and adjusts the flux according to product demand under normal growth conditions. These data illustrate the central relevance of photosynthesis, the circadian clock and feedback control of DXS for the diurnal regulation of the MEP pathway.
Isoprenoid molecules are essential elements of plant metabolism. Many important plant isoprenoids, such as chlorophylls, carotenoids, tocopherols, prenylated quinones and hormones are synthesised in chloroplasts via the 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway. Here we develop a mathematical model of diurnal regulation of the MEP pathway in Arabidopsis thaliana. We used both experimental and theoretical approaches to integrate mechanisms potentially involved in the diurnal control of the pathway. Our data show that flux through the MEP pathway is accelerated in light due to the photosynthesis-dependent supply of metabolic substrates of the pathway and the transcriptional regulation of key biosynthetic genes by the circadian clock. We also demonstrate that feedback regulation of both the activity and the abundance of the first enzyme of the MEP pathway (1-deoxy-D-xylulose 5-phosphate synthase, DXS) by pathway products stabilizes the flux against changes in substrate supply and adjusts the flux according to product demand under normal growth conditions. These data illustrate the central relevance of photosynthesis, the circadian clock and feedback control of DXS for the diurnal regulation of the MEP pathway.Isoprenoid molecules are essential elements of plant metabolism. Many important plant isoprenoids, such as chlorophylls, carotenoids, tocopherols, prenylated quinones and hormones are synthesised in chloroplasts via the 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway. Here we develop a mathematical model of diurnal regulation of the MEP pathway in Arabidopsis thaliana. We used both experimental and theoretical approaches to integrate mechanisms potentially involved in the diurnal control of the pathway. Our data show that flux through the MEP pathway is accelerated in light due to the photosynthesis-dependent supply of metabolic substrates of the pathway and the transcriptional regulation of key biosynthetic genes by the circadian clock. We also demonstrate that feedback regulation of both the activity and the abundance of the first enzyme of the MEP pathway (1-deoxy-D-xylulose 5-phosphate synthase, DXS) by pathway products stabilizes the flux against changes in substrate supply and adjusts the flux according to product demand under normal growth conditions. These data illustrate the central relevance of photosynthesis, the circadian clock and feedback control of DXS for the diurnal regulation of the MEP pathway.
Author Rodríguez‐Concepción, Manuel
Ebenhöh, Oliver
Bou‐Torrent, Jordi
Pokhilko, Alexandra
Pulido, Pablo
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/25598499$$D View this record in MEDLINE/PubMed
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Keywords Arabidopsis thaliana
systems biology
mathematical modelling
isoprenoids
2-C-methyl-D-erythritol 4-phosphate (MEP) pathway
whole plant physiology
plant metabolism
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Snippet Isoprenoid molecules are essential elements of plant metabolism. Many important plant isoprenoids, such as chlorophylls, carotenoids, tocopherols, prenylated...
Summary Isoprenoid molecules are essential elements of plant metabolism. Many important plant isoprenoids, such as chlorophylls, carotenoids, tocopherols,...
Summary Isoprenoid molecules are essential elements of plant metabolism. Many important plant isoprenoids, such as chlorophylls, carotenoids, tocopherols,...
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SubjectTerms 2‐C‐methyl‐D‐erythritol 4‐phosphate (MEP) pathway
Arabidopsis - metabolism
Arabidopsis - radiation effects
Arabidopsis thaliana
Biological clocks
Carotenoids
Chlorophyll
Chloroplasts
Circadian Clocks
Circadian Rhythm
Circadian rhythms
Diurnal
Erythritol
Erythritol - analogs & derivatives
Erythritol - metabolism
Feedback
Feedback control
Fluctuations
Flux
Gene regulation
genes
Growth conditions
Hormones
isoprenoids
Mathematical analysis
mathematical modelling
Mathematical models
Metabolic Networks and Pathways
Model testing
Models, Biological
Phosphates
Photosynthesis
Plant metabolism
Quinones
Substrates
Sugar Phosphates - metabolism
systems biology
Terpenes
Tocopherols
Transcription
transcription (genetics)
whole plant physiology
Xylulose
Title Mathematical modelling of the diurnal regulation of the MEP pathway in Arabidopsis
URI https://www.jstor.org/stable/newphytologist.206.3.1075
https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fnph.13258
https://www.ncbi.nlm.nih.gov/pubmed/25598499
https://www.proquest.com/docview/1671983459
https://www.proquest.com/docview/2513911761
https://www.proquest.com/docview/1673073035
https://www.proquest.com/docview/1694501706
Volume 206
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