Safety, Pharmacokinetics, and Pharmacodynamics of Multiple Rising Doses of BI 655064, an Antagonistic Anti‐CD40 Antibody, in Healthy Subjects: A Potential Novel Treatment for Autoimmune Diseases - Schwabe, Christian; Rosenstock, Bernd; Doan, Thi; Hamilton, Paul; Dunbar, P. Rod; Eleftheraki, Anastasia G.; Joseph, David; Hilbert, James; Schoelch, Corinna; Padula, Steven J.; Steffgen, Jürgen (Journal of clinical pharmacology, 2018)
Keywords: Adult; Antibodies, Monoclonal, Humanized - administration & dosage; Antibodies, Monoclonal, Humanized - adverse effects; Antibodies, Monoclonal, Humanized - pharmacokinetics; Antibodies, Monoclonal, Humanized - pharmacology; anti‐CD40; Area Under Curve; Autoimmune Diseases - therapy; CD40 Antigens - immunology; Dose-Response Relationship, Drug; Double-Blind Method; Female; healthy subjects; Humans; lupus nephritis; Male; multiple rising dose; rheumatoid arthritis; systemic lupus erythematosus; Young Adult; anti-CD40; multiple rising dose; lupus nephritis; systemic lupus erythematosus; healthy subjects; rheumatoid arthritis