Glycolysis – a key player in the inflammatory response

• Published in: The FEBS journal Vol. 287; no. 16; pp. 3350 - 3369
• Main Authors: Soto‐Heredero, Gonzalo, Gómez de las Heras, Manuel M., Gabandé‐Rodríguez, Enrique, Oller, Jorge, Mittelbrunn, María
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.08.2020; John Wiley and Sons Inc
• Subjects: ageing; Animals; beta oxidation; Cell activation; Citric Acid Cycle - immunology; energy; Epigenetics; Fatty acids; Gene regulation; Glycolysis; Glycolysis - immunology; Helper cells; Humans; immune cells; Immune system; immunometabolism; Immunoregulation; Inflammation; Inflammation - immunology; Inflammation - metabolism; Inflammatory response; Lactic acid; Lymphocytes; Lymphocytes T; Macrophage Activation - immunology; Macrophages; Macrophages - classification; Macrophages - immunology; Macrophages - metabolism; Metabolism; Metabolites; Microglia; Molecular modelling; Neurodegenerative diseases; Neurodegenerative Diseases - immunology; Neurodegenerative Diseases - metabolism; neuroglia; Oxidation; phenotype; Phenotypes; State‐of‐the‐Art Review; State‐of‐the‐Art Reviews; T-Lymphocytes, Helper-Inducer - immunology; T-Lymphocytes, Helper-Inducer - metabolism; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - metabolism; Transcription; Tricarboxylic acid cycle; immune cells; ageing; immunometabolism; inflammation; metabolites

The inflammatory response involves the activation of several cell types to fight insults caused by a plethora of agents, and to maintain the tissue homoeostasis. On the one hand, cells involved in the pro‐inflammatory response, such as inflammatory M1 macrophages, Th1 and Th17 lymphocytes or activat...