Molecular dissection of plasmacytoid dendritic cell activation in vivo during a viral infection

• Published in: The EMBO journal Vol. 37; no. 19
• Main Authors: Tomasello, Elena, Naciri, Karima, Chelbi, Rabie, Bessou, Gilles, Fries, Anissa, Gressier, Elise, Abbas, Abdenour, Pollet, Emeline, Pierre, Philippe, Lawrence, Toby, Vu Manh, Thien‐Phong, Dalod, Marc
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2018; Springer Nature B.V; EMBO Press; John Wiley and Sons Inc
• Subjects: Cell activation; Cell interactions; CpG islands; Cytokines; Cytomegalovirus; Dendritic cells; Deoxyribonucleic acid; DNA; EMBO19; EMBO23; Feedback; Gene expression; Immune system; Immunology; Infections; Injection; Interferon; Interferon regulatory factor; Interferon regulatory factor 7; IRF7; Life Sciences; Ligands; mouse cytomegalovirus; MyD88 protein; Phosphorylation; plasmacytoid dendritic cells; Positive feedback; Proteins; Receptors; Ribonucleic acid; RNA; Signal transduction; Signaling; TLR9 protein; Toll-like receptors; type I interferons; viral infection; Viral infections; IRF7; plasmacytoid dendritic cells; viral infection; mouse cytomegalovirus; type I interferons; Virology & Host Pathogen Interaction; Microbiology; viral infection Subject Categories Immunology

Plasmacytoid dendritic cells (pDC) are the major source of type I interferons (IFN‐I) during viral infections, in response to triggering of endosomal Toll‐like receptors (TLRs) 7 or 9 by viral single‐stranded RNA or unmethylated CpG DNA, respectively. Synthetic ligands have been used to disentangle...