Combinatorially Designed Lipid-like Nanoparticles for Intracellular Delivery of Cytotoxic Protein for Cancer Therapy

• Published in: Angewandte Chemie International Edition Vol. 53; no. 11; pp. 2893 - 2898
• Main Authors: Wang, Ming, Alberti, Kyle, Sun, Shuo, Arellano, Carlos Luis, Xu, Qiaobing
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 10.03.2014; WILEY‐VCH Verlag; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Aconitic Acid - analogs & derivatives; Aconitic Acid - chemistry; Alkanes - chemistry; Amines - chemistry; Animals; Antineoplastic Agents - administration & dosage; Cancer; cancer therapy; Cationic; Cell growth; Cell Line, Tumor; Cell Survival - drug effects; Combinatorial analysis; Cytotoxicity; Humans; lipidoids; Lipids - chemistry; Mathematical models; Mice; Nanoparticles; Nanoparticles - chemistry; Neoplasms - drug therapy; Platforms; protein delivery; Proteins; Ribonuclease, Pancreatic - metabolism; Ribonuclease, Pancreatic - therapeutic use; Ribonuclease, Pancreatic - toxicity; Ribosome Inactivating Proteins, Type 1 - metabolism; Ribosome Inactivating Proteins, Type 1 - therapeutic use; Ribosome Inactivating Proteins, Type 1 - toxicity; Tumors; cancer therapy; lipidoids; nanoparticles; protein delivery

An efficient and safe method to deliver active proteins into the cytosol of targeted cells is highly desirable to advance protein‐based therapeutics. A novel protein delivery platform has been created by combinatorial design of cationic lipid‐like materials (termed “lipidoids”), coupled with a rever...