Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise

• Published in: The FEBS journal Vol. 290; no. 6; pp. 1420 - 1453
• Main Author: Yin, Fei
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.03.2023
• Subjects: Alzheimer disease; Alzheimer Disease - pathology; Alzheimer's disease; Amyloidogenesis; Apolipoprotein E; Brain - metabolism; Degeneration; Energy Metabolism; Environmental risk; Etiology; fatty acid; Health risks; Humans; Inflammation; Lipid Metabolism; lipidomics; Lipids; Metabolism; Metabolomics; Myelin; myelin sheath; Neurodegeneration; Neurodegenerative diseases; neuropathology; Oxidative Stress; Pathogenesis; risk; Risk factors; therapeutics; alzheimer’s disease; fatty acid; therapeutics; lipid metabolism

Alzheimer’s disease (AD) is an age‐associated neurodegenerative disorder with multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of disease‐modifying therapeutics. While the abnormal accumulation of lipids was described in the very first report of AD neuropathol...