Cellular senescence: all roads lead to mitochondria

• Published in: The FEBS journal Vol. 290; no. 5; pp. 1186 - 1202
• Main Authors: Martini, Hélène, Passos, João F.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.03.2023
• Subjects: ageing; cell cycle checkpoints; Cell death; Cell fate; cell senescence; Cellular Senescence; industry; Inflammation; Mitochondria; Phenotype; Phenotypes; SASP; Senescence; Therapeutic applications; therapeutics; senescence; ageing; SASP; mitochondria

Senescence is a multi‐functional cell fate, characterized by an irreversible cell‐cycle arrest and a pro‐inflammatory phenotype, commonly known as the senescence‐associated secretory phenotype (SASP). Emerging evidence indicates that accumulation of senescent cells in multiple tissues drives tissue...