Biosynthetic Code for Divergolide Assembly in a Bacterial Mangrove Endophyte

• Published in: Chembiochem : a European journal of chemical biology Vol. 15; no. 9; pp. 1274 - 1279
• Main Authors: Xu, Zhongli, Baunach, Martin, Ding, Ling, Peng, Huiyun, Franke, Jakob, Hertweck, Christian
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 16.06.2014; WILEY‐VCH Verlag; Wiley; Wiley Subscription Services, Inc
• Subjects: ansamycins; Bacteria; Biochemistry & Molecular Biology; biosynthesis; Bruguiera gymnorrhiza; Chemistry, Medicinal; divergolides; Life Sciences & Biomedicine; Macrolides - chemistry; Macrolides - isolation & purification; Macrolides - metabolism; modular polyketide synthases; Molecular Conformation; Pharmacology & Pharmacy; polyketides; Rhizophoraceae - microbiology; Science & Technology; Streptomyces; Streptomyces - chemistry; Streptomyces - metabolism; ACID; AMYCOLATOPSIS-MEDITERRANEI S699; ansamycins; DOUBLE-BOND MIGRATION; CONFIGURATION; modular polyketide synthases; STEREOCHEMICAL DETERMINATION; MYXOBACTERIUM-SORANGIUM-CELLULOSUM; polyketides; RIFAMYCIN; divergolides; GENE-CLUSTER; biosynthesis; ACTINOSYNNEMA-PRETIOSUM

Divergolides are structurally diverse ansamycins produced by a bacterial endophyte (Streptomyces sp.) of the mangrove tree Bruguiera gymnorrhiza. By genomic analyses a gene locus coding for the divergolide pathway was detected. The div gene cluster encodes genes for the biosynthesis of 3‐amino‐5‐hyd...