Infection‐induced inflammation from specific inborn errors of immunity to COVID‐19

• Published in: The FEBS journal Vol. 288; no. 17; pp. 5021 - 5041
• Main Authors: Ku, Cheng‐Lung, Chen, I‐Ting, Lai, Ming‐Zong
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.09.2021; John Wiley and Sons Inc
• Subjects: anticytokine autoantibodies; Autoantibodies; Coronaviruses; COVID-19; COVID-19 - genetics; COVID-19 - immunology; COVID-19 - virology; COVID-19 infection; Humans; Immune response; Immune system; Immunity; Immunity - genetics; inborn errors of immunity; Infections; Inflammation; Inflammation - genetics; Inflammation - immunology; Inflammation - virology; Interferon; Interferon Type I - genetics; loss-of-function mutation; Lymphocytes; Metabolism, Inborn Errors - genetics; Metabolism, Inborn Errors - immunology; mortality; Mutation; Pathogens; Respiratory diseases; SARS-CoV-2 - immunology; SARS-CoV-2 - pathogenicity; SARS‐CoV‐2; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Signaling; State‐of‐the‐Art Review; State‐of‐the‐Art Reviews; therapeutics; Viral diseases; Virus Diseases - genetics; Virus Diseases - immunology; Virus Diseases - virology; XLP‐2; COVID-19; SARS-CoV-2; XLP-2; inborn errors of immunity; anticytokine autoantibodies

Inborn errors of immunity (IEIs) are a group of genetically defined disorders leading to defective immunity. Some IEIs have been linked to mutations of immune receptors or signaling molecules, resulting in defective signaling of respective cascades essential for combating specific pathogens. However...