Somatic mutations precede acute myeloid leukemia years before diagnosis - Desai, Pinkal; Mencia-Trinchant, Nuria; Savenkov, Oleksandr; Simon, Michael S; Cheang, Gloria; Lee, Sangmin; Samuel, Michael; Ritchie, Ellen K; Guzman, Monica L; Ballman, Karla V; Roboz, Gail J; Hassane, Duane C (Nature medicine, 2018)
Keywords: Acute myeloid leukemia; Alleles; Case-Control Studies; Clonal Evolution; Deoxyribonucleic acid; Diagnosis; Disease Progression; DNA; DNA sequencing; Female; Health promotion; Humans; Latency; Leukemia; Leukemia, Myeloid, Acute - blood; Leukemia, Myeloid, Acute - diagnosis; Leukemia, Myeloid, Acute - genetics; Multivariate Analysis; Mutation; Mutation - genetics; Mutation Rate; Myeloid leukemia; Odds Ratio; p53 Protein; Patients; Peripheral blood; Risk Factors