Sleeve Gastrectomy Improves Hepatic Glucose Metabolism by Downregulating FBXO2 and Activating the PI3K-AKT Pathway

• Published in: International journal of molecular sciences Vol. 24; no. 6; p. 5544
• Main Authors: Chen, Ningyuan, Cao, Ruican, Zhang, Zhao, Zhou, Sai, Hu, Sanyuan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 14.03.2023; MDPI
• Subjects: Animals; Blood Glucose - analysis; Cell Cycle Proteins - metabolism; Comparative analysis; Dextrose; Diabetes; Diabetes Mellitus, Type 2 - metabolism; F-Box Proteins; Fatty acids; Fatty liver; Food; Gastrectomy; Gastrointestinal surgery; Glucose; Glucose - metabolism; Glucose tolerance tests; Health aspects; High density lipoprotein; Homeostasis; Humans; Insulin; Insulin resistance; Lipids; Liver; Liver diseases; Metabolism; Mice; Nerve Tissue Proteins - metabolism; Obesity; Phosphatidylinositol 3-Kinases - metabolism; Phosphorylation; Physiological aspects; Proteins; Proto-Oncogene Proteins c-akt - metabolism; Remission (Medicine); Type 2 diabetes; Weight control; China; T2DM; SG; glucose metabolism; FBXO2; PI3K-AKT pathway

Type 2 diabetes mellitus (T2DM), a chronic metabolic disease, is a public health concern that seriously endangers human health. Sleeve gastrectomy (SG) can relieve T2DM by improving glucose homeostasis and enhancing insulin sensitivity. However, its specific underlying mechanism remains elusive. SG...