Strategies for combating bacterial biofilm infections

Formation of biofilm is a survival strategy for bacteria and fungi to adapt to their living environment, especially in the hostile environment. Under the protection of biofilm, microbial cells in biofilm become tolerant and resistant to antibiotics and the immune responses, which increases the diffi...

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Published in	International journal of oral science Vol. 7; no. 1; pp. 1 - 7
Main Authors	Wu, Hong, Moser, Claus, Wang, Heng-Zhuang, Høiby, Niels, Song, Zhi-Jun
Format	Journal Article
Language	English
Published	London Nature Publishing Group UK 01.03.2015 Springer Nature B.V Department of Clinical Microbiology, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark Nature Publishing Group
Subjects	Anti-Bacterial Agents - therapeutic use Bacteria Bacterial Infections - drug therapy Bacterial Infections - microbiology Biofilms Dentistry Drug Resistance, Bacterial Humans Medicine Oral and Maxillofacial Surgery Orthopedics Review Surgical Orthopedics 临床治疗实验室微生物细胞感染抗生素治疗生活环境生物膜活性细菌生物膜 antimicrobial treatments antibiotic resistance chronic infection bacterial biofilm
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Abstract	Formation of biofilm is a survival strategy for bacteria and fungi to adapt to their living environment, especially in the hostile environment. Under the protection of biofilm, microbial cells in biofilm become tolerant and resistant to antibiotics and the immune responses, which increases the difficulties for the clinical treatment of biofilm infections. Clinical and laboratory investigations demonstrated a perspicuous correlation between biofilm infection and medical foreign bodies or indwelling devices. Clinical observations and experimental studies indicated clearly that antibiotic treatment alone is in most cases insufficient to eradicate biofilm infections. Therefore, to effectively treat biofilm infections with currently available antibiotics and evaluate the outcomes become important and urgent for clinicians. The review summarizes the latest progress in treatment of clinical biofilm infections and scientific investigations, discusses the diagnosis and treatment of different biofilm infections and introduces the promising laboratory progress, which may contribute to prevention or cure of biofilm infections. We conclude that, an efficient treatment of biofilm infections needs a well-established multidisciplinary collaboration, which includes removal of the infected foreign bodies, selection of biofilm-active, sensitive and well-penetrating antibiotics, systemic or topical antibiotic administration in high dosage and combinations, and administration of anti-quorum sensing or biofilm dispersal agents.
AbstractList	Formation of biofilm is a survival strategy for bacteria and fungi to adapt to their living environment, especially in the hostile environment. Under the protection of biofilm, microbial cells in biofilm become tolerant and resistant to antibiotics and the immune responses, which increases the difficulties for the clinical treatment of biofilm infections. Clinical and laboratory investigations demonstrated a perspicuous correlation between biofilm infection and medical foreign bodies or indwelling devices. Clinical observations and experimental studies indicated clearly that antibiotic treatment alone is in most cases insufficient to eradicate biofilm infections. Therefore, to effectively treat biofilm infections with currently available antibiotics and evaluate the outcomes become important and urgent for clinicians. The review summarizes the latest progress in treatment of clinical biofilm infections and scientific investigations, discusses the diagnosis and treatment of different biofilm infections and introduces the promising laboratory progress, which may contribute to prevention or cure of biofilm infections. We conclude that, an efficient treatment of biofilm infections needs a well-established multidisciplinary collaboration, which includes removal of the infected foreign bodies, selection of biofilm-active, sensitive and well-penetrating antibiotics, systemic or topical antibiotic administration in high dosage and combinations, and administration of anti-quorum sensing or biofilm dispersal agents. Formation of biofilm is a survival strategy for bacteria and fungi to adapt to their living environment, especially in the hostile environment. Under the protection of biofilm, microbial cells in biofilm become tolerant and resistant to antibiotics and the immune responses, which increases the difficulties for the clinical treatment of biofilm infections. Clinical and laboratory investigations demonstrated a perspicuous correlation between biofilm infection and medical foreign bodies or indwelling devices. Clinical observations and experimental studies indicated clearly that antibiotic treatment alone is in most cases insufficient to eradicate biofilm infections. Therefore, to effectively treat biofilm infections with currently available antibiotics and evaluate the outcomes become important and urgent for clinicians. The review summarizes the latest progress in treatment of clinical biofilm infections and scientific investigations, discusses the diagnosis and treatment of different biofilm infections and introduces the promising laboratory progress, which may contribute to prevention or cure of biofilm infections. We conclude that, an efficient treatment of biofilm infections needs a well-established multidisciplinary collaboration, which includes removal of the infected foreign bodies, selection of biofilm-active, sensitive and well-penetrating antibiotics, systemic or topical antibiotic administration in high dosage and combinations, and administration of anti-quorum sensing or biofilm dispersal agents. Microbiology: Combating bacterial biofilm infections Antibiotics alone are often ineffective in the treatment of bacterial biofilm infections and new strategies are needed. Once bacteria shift from their free-swimming state to the structured community of a biofilm, they become much harder to kill with conventional antibiotic regimens. A review by Zhi-Jun Song and colleagues at Denmark’s University Hospital of Copenhagen explores the challenges of diagnosing and eliminating biofilms that form on the surface of implanted medical devices. At present, the best solution is early detection followed by aggressive treatment with multiple antibiotics and removal of the device in question. However, recent research suggests other possible solutions, including drugs that interfere with communication between bacteria or disrupt their ability to anchor to surfaces, and viruses that specifically infect and kill biofilm-forming microbes. Formation of biofilm is a survival strategy for bacteria and fungi to adapt to their living environment, especially in the hostile environment. Under the protection of biofilm, microbial cells in biofilm become tolerant and resistant to antibiotics and the immune responses, which increases the difficulties for the clinical treatment of biofilm infections. Clinical and laboratory investigations demonstrated a perspicuous correlation between biofilm infection and medical foreign bodies or indwelling devices. Clinical observations and experimental studies indicated clearly that antibiotic treatment alone is in most cases insufficient to eradicate biofilm infections. Therefore, to effectively treat biofilm infections with currently available antibiotics and evaluate the outcomes become important and urgent for clinicians. The review summarizes the latest progress in treatment of clinical biofilm infections and scientific investigations, discusses the diagnosis and treatment of different biofilm infections and introduces the promising laboratory progress, which may contribute to prevention or cure of biofilm infections. We conclude that, an efficient treatment of biofilm infections needs a well-established multidisciplinary collaboration, which includes removal of the infected foreign bodies, selection of biofilm-active, sensitive and well-penetrating antibiotics, systemic or topical antibiotic administration in high dosage and combinations, and administration of anti-quorum sensing or biofilm dispersal agents.Formation of biofilm is a survival strategy for bacteria and fungi to adapt to their living environment, especially in the hostile environment. Under the protection of biofilm, microbial cells in biofilm become tolerant and resistant to antibiotics and the immune responses, which increases the difficulties for the clinical treatment of biofilm infections. Clinical and laboratory investigations demonstrated a perspicuous correlation between biofilm infection and medical foreign bodies or indwelling devices. Clinical observations and experimental studies indicated clearly that antibiotic treatment alone is in most cases insufficient to eradicate biofilm infections. Therefore, to effectively treat biofilm infections with currently available antibiotics and evaluate the outcomes become important and urgent for clinicians. The review summarizes the latest progress in treatment of clinical biofilm infections and scientific investigations, discusses the diagnosis and treatment of different biofilm infections and introduces the promising laboratory progress, which may contribute to prevention or cure of biofilm infections. We conclude that, an efficient treatment of biofilm infections needs a well-established multidisciplinary collaboration, which includes removal of the infected foreign bodies, selection of biofilm-active, sensitive and well-penetrating antibiotics, systemic or topical antibiotic administration in high dosage and combinations, and administration of anti-quorum sensing or biofilm dispersal agents.
Author	Hong Wu Claus Moser Heng-Zhuang Wang Niels Hoiby Zhi-Jun Song
AuthorAffiliation	Department of Clinical Microbiology, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark Department of International Health, Immunology ＆ Microbiology, Universit：yof Copenhagen, Coperlhagen, Denmark Department of Clinical Microbiology, Slagelse Hospital, Slagelse, Denmark
AuthorAffiliation_xml	– name: Department of Clinical Microbiology, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark
Author_xml	– sequence: 1 givenname: Hong surname: Wu fullname: Wu, Hong organization: Department of Clinical Microbiology, Rigshospitalet, University Hospital of Copenhagen, Department of International Health, Immunology & Microbiology, University of Copenhagen – sequence: 2 givenname: Claus surname: Moser fullname: Moser, Claus organization: Department of Clinical Microbiology, Rigshospitalet, University Hospital of Copenhagen – sequence: 3 givenname: Heng-Zhuang surname: Wang fullname: Wang, Heng-Zhuang organization: Department of Clinical Microbiology, Rigshospitalet, University Hospital of Copenhagen – sequence: 4 givenname: Niels surname: Høiby fullname: Høiby, Niels organization: Department of Clinical Microbiology, Rigshospitalet, University Hospital of Copenhagen, Department of International Health, Immunology & Microbiology, University of Copenhagen – sequence: 5 givenname: Zhi-Jun surname: Song fullname: Song, Zhi-Jun email: szj56@hotmail.com organization: Department of Clinical Microbiology, Rigshospitalet, University Hospital of Copenhagen, Department of Clinical Microbiology, Slagelse Hospital
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/25504208$$D View this record in MEDLINE/PubMed
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Copyright	The Author(s) 2014 Copyright Nature Publishing Group Mar 2015 Copyright © Wanfang Data Co. Ltd. All Rights Reserved. Copyright © 2014 West China School of Stomatology 2014 West China School of Stomatology
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DocumentTitleAlternate	Strategies for combating bacterial biofilm infections Combating biofilm infections
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Keywords	antimicrobial treatments antibiotic resistance chronic infection bacterial biofilm
Language	English
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Notes	51-1707/R antibiotic resistance; antimicrobial treatments; bacterial biofilm; chronic infection Formation of biofilm is a survival strategy for bacteria and fungi to adapt to their living environment, especially in the hostile environment. Under the protection of biofilm, microbial cells in biofilm become tolerant and resistant to antibiotics and the immune responses, which increases the difficulties for the clinical treatment of biofilm infections. Clinical and laboratory investigations demonstrated a perspicuous correlation between biofilm infection and medical foreign bodies or indwelling devices. Clinical observations and experimental studies indicated clearly that antibiotic treatment alone is in most cases insufficient to eradicate biofilm infections. Therefore, to effectively treat biofilm infections with currently available antibiotics and evaluate the outcomes become important and urgent for clinicians. The review summarizes the latest progress in treatment of clinical biofilm infections and scientific investigations, discusses the diagnosis and treatment of different biofilm infections and introduces the promising laboratory progress, which may contribute to prevention or cure of biofilm infections. We conclude that, an efficient treatment of biofilm infections needs a well-established multidisciplinary collaboration, which includes removal of the infected foreign bodies, selection of biofilm-active, sensitive and well-penetrating antibiotics, systemic or topical antibiotic administration in high dosage and combinations, and administration of anti-quorum sensing or biofilm dispersal agents. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Review-3
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Publisher	Nature Publishing Group UK Springer Nature B.V Department of Clinical Microbiology, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark Nature Publishing Group
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SubjectTerms	Anti-Bacterial Agents - therapeutic use Bacteria Bacterial Infections - drug therapy Bacterial Infections - microbiology Biofilms Dentistry Drug Resistance, Bacterial Humans Medicine Oral and Maxillofacial Surgery Orthopedics Review Surgical Orthopedics 临床治疗实验室微生物细胞感染抗生素治疗生活环境生物膜活性细菌生物膜
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Title	Strategies for combating bacterial biofilm infections
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