MicroRNAs and MAPKs: Evidence of These Molecular Interactions in Alzheimer's Disease
Alzheimer's disease (AD) is a neurodegenerative disorder known to be the leading cause of dementia worldwide. Many microRNAs (miRNAs) were found deregulated in the brain or blood of AD patients, suggesting a possible key role in different stages of neurodegeneration. In particular, mitogen-acti...
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Published in | International journal of molecular sciences Vol. 24; no. 5; p. 4736 |
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Language | English |
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Abstract | Alzheimer's disease (AD) is a neurodegenerative disorder known to be the leading cause of dementia worldwide. Many microRNAs (miRNAs) were found deregulated in the brain or blood of AD patients, suggesting a possible key role in different stages of neurodegeneration. In particular, mitogen-activated protein kinases (MAPK) signaling can be impaired by miRNA dysregulation during AD. Indeed, the aberrant MAPK pathway may facilitate the development of amyloid-beta (Aβ) and Tau pathology, oxidative stress, neuroinflammation, and brain cell death. The aim of this review was to describe the molecular interactions between miRNAs and MAPKs during AD pathogenesis by selecting evidence from experimental AD models. Publications ranging from 2010 to 2023 were considered, based on PubMed and Web of Science databases. According to obtained data, several miRNA deregulations may regulate MAPK signaling in different stages of AD and conversely. Moreover, overexpressing or silencing miRNAs involved in MAPK regulation was seen to improve cognitive deficits in AD animal models. In particular, miR-132 is of particular interest due to its neuroprotective functions by inhibiting Aβ and Tau depositions, as well as oxidative stress, through ERK/MAPK1 signaling modulation. However, further investigations are required to confirm and implement these promising results. |
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AbstractList | Alzheimer’s disease (AD) is a neurodegenerative disorder known to be the leading cause of dementia worldwide. Many microRNAs (miRNAs) were found deregulated in the brain or blood of AD patients, suggesting a possible key role in different stages of neurodegeneration. In particular, mitogen-activated protein kinases (MAPK) signaling can be impaired by miRNA dysregulation during AD. Indeed, the aberrant MAPK pathway may facilitate the development of amyloid-beta (Aβ) and Tau pathology, oxidative stress, neuroinflammation, and brain cell death. The aim of this review was to describe the molecular interactions between miRNAs and MAPKs during AD pathogenesis by selecting evidence from experimental AD models. Publications ranging from 2010 to 2023 were considered, based on PubMed and Web of Science databases. According to obtained data, several miRNA deregulations may regulate MAPK signaling in different stages of AD and conversely. Moreover, overexpressing or silencing miRNAs involved in MAPK regulation was seen to improve cognitive deficits in AD animal models. In particular, miR-132 is of particular interest due to its neuroprotective functions by inhibiting Aβ and Tau depositions, as well as oxidative stress, through ERK/MAPK1 signaling modulation. However, further investigations are required to confirm and implement these promising results. |
Audience | Academic |
Author | Raffaele, Ivana Silvestro, Serena Mazzon, Emanuela |
AuthorAffiliation | IRCCS Centro Neurolesi Bonino Pulejo, Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy |
AuthorAffiliation_xml | – name: IRCCS Centro Neurolesi Bonino Pulejo, Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy |
Author_xml | – sequence: 1 givenname: Ivana surname: Raffaele fullname: Raffaele, Ivana organization: IRCCS Centro Neurolesi Bonino Pulejo, Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy – sequence: 2 givenname: Serena orcidid: 0000-0003-3846-0785 surname: Silvestro fullname: Silvestro, Serena organization: IRCCS Centro Neurolesi Bonino Pulejo, Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy – sequence: 3 givenname: Emanuela surname: Mazzon fullname: Mazzon, Emanuela organization: IRCCS Centro Neurolesi Bonino Pulejo, Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36902178$$D View this record in MEDLINE/PubMed |
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CitedBy_id | crossref_primary_10_1016_j_jep_2024_118530 crossref_primary_10_1155_2023_8537296 crossref_primary_10_35516_jjps_v17i2_1895 crossref_primary_10_1007_s00344_024_11239_5 crossref_primary_10_1186_s13578_023_01190_5 |
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Keywords | microRNAs neurodegeneration Alzheimer’s disease MAPK |
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Snippet | Alzheimer's disease (AD) is a neurodegenerative disorder known to be the leading cause of dementia worldwide. Many microRNAs (miRNAs) were found deregulated in... Alzheimer’s disease (AD) is a neurodegenerative disorder known to be the leading cause of dementia worldwide. Many microRNAs (miRNAs) were found deregulated in... |
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SubjectTerms | Advertising executives Alzheimer Disease - metabolism Alzheimer's disease Amyloid beta-Peptides - metabolism Animal models Animals Brain - metabolism Cell death Dementia disorders Deregulation Development and progression Inflammation Kinases MAP kinase MAPK MicroRNA MicroRNAs MicroRNAs - genetics miRNA Mitogen-Activated Protein Kinases - metabolism Molecular interactions Neurodegeneration Neuroprotection Oxidative stress Pathogenesis Pathology Protein kinases Review Signal Transduction Tau protein |
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Title | MicroRNAs and MAPKs: Evidence of These Molecular Interactions in Alzheimer's Disease |
URI | https://www.ncbi.nlm.nih.gov/pubmed/36902178 https://www.proquest.com/docview/2785219184 https://search.proquest.com/docview/2786094896 https://pubmed.ncbi.nlm.nih.gov/PMC10003111 https://doaj.org/article/ecc5474123674267833b06fb3419e7ce |
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