Interleukin-33 upregulation in peripheral leukocytes and CNS of multiple sclerosis patients

• Published in: Clinical immunology (Orlando, Fla.) Vol. 142; no. 3; pp. 308 - 319
• Main Authors: Christophi, George P., Gruber, Ross C., Panos, Michael, Christophi, Rebecca L., Jubelt, Burk, Massa, Paul T.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.03.2012; Elsevier
• Subjects: Adult; Allergy and Immunology; Astrocytes; Autoimmunity; Biological and medical sciences; Cells, Cultured; Central Nervous System - immunology; Demyelination; EAE; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Humans; IL-33; Inflammation; Interleukin-33; Interleukins - immunology; Lymphocytes - immunology; Macrophages - immunology; Male; Medical sciences; Middle Aged; Multiple Sclerosis - immunology; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis; Neurology; NF-kappa B - immunology; Up-Regulation; Autoimmunity; EAE; Inflammation; Demyelination; Astrocytes; IL-33; Human; Nervous system diseases; Multiple sclerosis; Leukocyte; Neuroglia; Interleukin; Cytokine; Astrocyte; Experimental allergic encephalomyelitis; Inflammatory disease; Immunology; Central nervous system disease

Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system (CNS). Here we document for the first time that the cytokine IL-33 is upregulated in both the periphery and the CNS of MS patients. Plasma IL-33 was elevated in MS patients compared to normal subjects a...