Interleukin-33 upregulation in peripheral leukocytes and CNS of multiple sclerosis patients

Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system (CNS). Here we document for the first time that the cytokine IL-33 is upregulated in both the periphery and the CNS of MS patients. Plasma IL-33 was elevated in MS patients compared to normal subjects a...

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Published inClinical immunology (Orlando, Fla.) Vol. 142; no. 3; pp. 308 - 319
Main Authors Christophi, George P., Gruber, Ross C., Panos, Michael, Christophi, Rebecca L., Jubelt, Burk, Massa, Paul T.
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier Inc 01.03.2012
Elsevier
Subjects
Adult
Allergy and Immunology
Astrocytes
Autoimmunity
Biological and medical sciences
Cells, Cultured
Central Nervous System - immunology
Demyelination
EAE
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
IL-33
Inflammation
Interleukin-33
Interleukins - immunology
Lymphocytes - immunology
Macrophages - immunology
Male
Medical sciences
Middle Aged
Multiple Sclerosis - immunology
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
NF-kappa B - immunology
Up-Regulation
Autoimmunity
EAE
Inflammation
Demyelination
Astrocytes
IL-33
Human
Nervous system diseases
Multiple sclerosis
Leukocyte
Neuroglia
Interleukin
Cytokine
Astrocyte
Experimental allergic encephalomyelitis
Inflammatory disease
Immunology
Central nervous system disease
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Abstract Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system (CNS). Here we document for the first time that the cytokine IL-33 is upregulated in both the periphery and the CNS of MS patients. Plasma IL-33 was elevated in MS patients compared to normal subjects and a three-month treatment of MS patients with interferon β-1a resulted in a significant decrease of IL-33 levels. Similarly, stimulated cultured lymphocytes and macrophages from MS patients had elevated IL-33 levels compared to normal subjects. In parallel, the transcription factor NF-κB that mediates IL-33 transcription was also elevated in leukocytes of MS patients. IL-33 was elevated in normal-appearing white matter and plaque areas from MS brains and astrocytes were identified as an important source of IL-33 expression in the CNS. In summary, IL-33 levels are elevated in the periphery and CNS of MS patients, implicating IL-33 in the pathogenesis of MS. ► The first study documenting IL-33 expression in multiple sclerosis. ► IL-33 was elevated in plasma and activated leukocytes of MS patients. ► Three-month treatment with interferon β-1a suppressed plasma IL-33 levels. ► IL-33 was elevated in brains of MS patients and astrocytes highly expressed IL-33. ► IL-33 is elevated in the periphery and CNS, implicating IL-33 in MS pathogenesis.
AbstractList Abstract Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system (CNS). Here we document for the first time that the cytokine IL-33 is upregulated in both the periphery and the CNS of MS patients. Plasma IL-33 was elevated in MS patients compared to normal subjects and a three-month treatment of MS patients with interferon β-1a resulted in a significant decrease of IL-33 levels. Similarly, stimulated cultured lymphocytes and macrophages from MS patients had elevated IL-33 levels compared to normal subjects. In parallel, the transcription factor NF-κB that mediates IL-33 transcription was also elevated in leukocytes of MS patients. IL-33 was elevated in normal-appearing white matter and plaque areas from MS brains and astrocytes were identified as an important source of IL-33 expression in the CNS. In summary, IL-33 levels are elevated in the periphery and CNS of MS patients, implicating IL-33 in the pathogenesis of MS.
Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system (CNS). Here we document for the first time that the cytokine IL-33 is upregulated in both the periphery and the CNS of MS patients. Plasma IL-33 was elevated in MS patients compared to normal subjects and a three-month treatment of MS patients with interferon β-1a resulted in a significant decrease of IL-33 levels. Similarly, stimulated cultured lymphocytes and macrophages from MS patients had elevated IL-33 levels compared to normal subjects. In parallel, the transcription factor NF-κB that mediates IL-33 transcription was also elevated in leukocytes of MS patients. IL-33 was elevated in normal-appearing white matter and plaque areas from MS brains and astrocytes were identified as an important source of IL-33 expression in the CNS. In summary, IL-33 levels are elevated in the periphery and CNS of MS patients, implicating IL-33 in the pathogenesis of MS. ► The first study documenting IL-33 expression in multiple sclerosis. ► IL-33 was elevated in plasma and activated leukocytes of MS patients. ► Three-month treatment with interferon β-1a suppressed plasma IL-33 levels. ► IL-33 was elevated in brains of MS patients and astrocytes highly expressed IL-33. ► IL-33 is elevated in the periphery and CNS, implicating IL-33 in MS pathogenesis.
Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system (CNS). Here we document for the first time that the cytokine IL-33 is upregulated in both the periphery and the CNS of MS patients. Plasma IL-33 was elevated in MS patients compared to normal subjects and a three-month treatment of MS patients with interferon β-1a resulted in significant decrease of IL-33 levels. Similarly, stimulated cultured lymphocytes and macrophages from MS patients had elevated IL-33 levels compared to normal subjects. In parallel, the transcription factor NF-κB that mediates IL-33 transcription was also elevated in leukocytes of MS patients. IL-33 was elevated in normal-appearing white matter and plaque areas from MS brains and astrocytes were identified as an important source of IL-33 expression in the CNS. In summary, IL-33 levels are elevated in the periphery and CNS of MS patients, implicating IL-33 in the pathogenesis of MS.
Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system (CNS). Here we document for the first time that the cytokine IL-33 is upregulated in both the periphery and the CNS of MS patients. Plasma IL-33 was elevated in MS patients compared to normal subjects and a three-month treatment of MS patients with interferon β-1a resulted in a significant decrease of IL-33 levels. Similarly, stimulated cultured lymphocytes and macrophages from MS patients had elevated IL-33 levels compared to normal subjects. In parallel, the transcription factor NF-κB that mediates IL-33 transcription was also elevated in leukocytes of MS patients. IL-33 was elevated in normal-appearing white matter and plaque areas from MS brains and astrocytes were identified as an important source of IL-33 expression in the CNS. In summary, IL-33 levels are elevated in the periphery and CNS of MS patients, implicating IL-33 in the pathogenesis of MS.Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system (CNS). Here we document for the first time that the cytokine IL-33 is upregulated in both the periphery and the CNS of MS patients. Plasma IL-33 was elevated in MS patients compared to normal subjects and a three-month treatment of MS patients with interferon β-1a resulted in a significant decrease of IL-33 levels. Similarly, stimulated cultured lymphocytes and macrophages from MS patients had elevated IL-33 levels compared to normal subjects. In parallel, the transcription factor NF-κB that mediates IL-33 transcription was also elevated in leukocytes of MS patients. IL-33 was elevated in normal-appearing white matter and plaque areas from MS brains and astrocytes were identified as an important source of IL-33 expression in the CNS. In summary, IL-33 levels are elevated in the periphery and CNS of MS patients, implicating IL-33 in the pathogenesis of MS.
Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system (CNS). Here we document for the first time that the cytokine IL-33 is upregulated in both the periphery and the CNS of MS patients. Plasma IL-33 was elevated in MS patients compared to normal subjects and a three-month treatment of MS patients with interferon β-1a resulted in a significant decrease of IL-33 levels. Similarly, stimulated cultured lymphocytes and macrophages from MS patients had elevated IL-33 levels compared to normal subjects. In parallel, the transcription factor NF-κB that mediates IL-33 transcription was also elevated in leukocytes of MS patients. IL-33 was elevated in normal-appearing white matter and plaque areas from MS brains and astrocytes were identified as an important source of IL-33 expression in the CNS. In summary, IL-33 levels are elevated in the periphery and CNS of MS patients, implicating IL-33 in the pathogenesis of MS.
Author Christophi, Rebecca L.
Jubelt, Burk
Panos, Michael
Massa, Paul T.
Gruber, Ross C.
Christophi, George P.
AuthorAffiliation 4 Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA
1 Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA
3 Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA
2 Department of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, NY, USA
AuthorAffiliation_xml – name: 1 Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA
– name: 2 Department of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, NY, USA
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– name: 3 Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA
Author_xml – sequence: 1
  givenname: George P.
  surname: Christophi
  fullname: Christophi, George P.
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– sequence: 2
  givenname: Ross C.
  surname: Gruber
  fullname: Gruber, Ross C.
  organization: Department of Neurology, Upstate Medical University State University of New York, 750 East Adams Street, Syracuse, NY, USA
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  surname: Panos
  fullname: Panos, Michael
  organization: Department of Neurology, Upstate Medical University State University of New York, 750 East Adams Street, Syracuse, NY, USA
– sequence: 4
  givenname: Rebecca L.
  surname: Christophi
  fullname: Christophi, Rebecca L.
  organization: Department of Microbiology & Immunology, Upstate Medical University State University of New York, 750 East Adams Street, Syracuse, NY USA
– sequence: 5
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– sequence: 6
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  surname: Massa
  fullname: Massa, Paul T.
  email: massap@upstate.edu
  organization: Department of Neurology, Upstate Medical University State University of New York, 750 East Adams Street, Syracuse, NY, USA
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Cites_doi 10.1186/1471-2172-11-52
10.1016/S0165-5728(98)00053-8
10.1002/ana.410370404
10.1016/j.immuni.2009.06.011
10.1038/labinvest.3700720
10.1016/j.immuni.2007.03.008
10.1080/13550280600873819
10.4049/jimmunol.1003574
10.1073/pnas.1000803107
10.1002/1531-8249(200006)47:6<707::AID-ANA3>3.0.CO;2-Q
10.1073/pnas.90.6.2517
10.1002/jnr.20482
10.1002/eji.200737547
10.1016/j.bbadis.2010.12.014
10.1002/ana.21116
10.1073/pnas.0801898105
10.4049/jimmunol.1000730
10.2174/187152708787122941
10.1038/ni.1864
10.1111/j.1365-2796.2010.02316.x
10.1016/j.jhep.2011.03.022
10.1111/j.1471-4159.2008.05337.x
10.1007/978-0-387-72005-0_45
10.1515/BC.2008.085
10.1002/eji.200940026
10.1073/pnas.0906988106
10.1152/ajpcell.00042.2008
10.1016/S0361-9230(03)00095-9
10.1371/journal.pone.0018404
10.1038/labinvest.3700663
10.1016/j.it.2010.11.004
10.1111/j.1471-4159.2004.02826.x
10.1016/S0021-9258(19)40123-3
10.1111/j.1471-4159.2006.03810.x
10.1038/ni.2045
10.1016/j.clim.2009.05.019
10.1083/jcb.127.4.1129
10.1189/jlb.1207830
10.1016/j.biocel.2011.06.003
10.1002/ana.410420106
10.1002/ana.1032
10.1016/j.brainres.2011.02.045
10.1111/j.1600-065X.2011.01046.x
10.1016/S0165-5728(02)00182-0
10.1128/JVI.01687-10
10.1016/0022-1759(93)90327-4
10.4049/jimmunol.1100229
10.1002/ana.21311
10.1111/j.1471-4159.2009.06008.x
10.1002/jnr.20995
10.1111/j.1365-2567.2009.03221.x
10.2741/1284
10.1016/j.cellsig.2008.05.013
10.4049/jimmunol.1003080
10.1189/jlb.0810470
10.1016/S0140-6736(98)03334-0
10.1016/j.immuni.2005.09.015
10.1084/jem.191.5.813
10.4049/jimmunol.0901575
10.1016/j.jneumeth.2007.03.022
10.1002/glia.1096
10.1002/jnr.22343
10.1093/intimm/dxr006
10.1128/JVI.01210-08
10.1038/ni.1824
10.1007/s11010-009-0244-9
10.1191/135245898678909141
10.1093/brain/awf142
10.1056/NEJM200009283431307
10.4049/jimmunol.0803067
10.1089/jir.1995.15.799
10.1111/j.1471-4159.2005.03364.x
10.1089/jir.1998.18.499
10.1038/labinvest.2009.32
10.1016/j.jns.2007.08.026
10.4049/jimmunol.180.6.4050
10.4049/jimmunol.179.4.2051
10.1016/j.tips.2005.11.002
10.1093/nar/29.4.e21
10.1002/ana.10764
10.1038/nri2692
10.4168/aair.2011.3.2.81
10.1016/j.cellsig.2010.10.006
10.1002/eji.200535271
10.1111/j.1750-3639.2007.00065.x
10.4049/jimmunol.1003383
10.1073/pnas.1003059107
10.1196/annals.1418.029
10.1016/j.immuni.2009.05.007
10.1002/glia.20958
10.1016/j.brainresrev.2004.12.008
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Issue 3
Keywords Autoimmunity
EAE
Inflammation
Demyelination
Astrocytes
IL-33
Human
Nervous system diseases
Multiple sclerosis
Leukocyte
Neuroglia
Interleukin
Cytokine
Astrocyte
Experimental allergic encephalomyelitis
Inflammatory disease
Immunology
Central nervous system disease
Language English
License https://www.elsevier.com/tdm/userlicense/1.0
CC BY 4.0
Copyright © 2011 Elsevier Inc. All rights reserved.
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References Jack, Ruffini, Bar-Or, Antel (bb0390) 2005; 81
Kurowska-Stolarska, Hueber, Stolarski, McInnes (bb0095) 2011; 269
Massa, Wu (bb0255) 1998; 18
Chakraborty, Kaushik, Gupta, Basu (bb0175) 2010; 88
Secor, Secor, Gutekunst, Brown (bb0340) 2000; 191
Lucchinetti, Bruck, Parisi, Scheithauer, Rodriguez, Lassmann (bb0010) 2000; 47
Feng, Petraglia, Chen, Byskosh, Boos, Reder (bb0035) 2002; 129
Breij, Brink, Veerhuis, van den Berg, Vloet, Yan (bb0365) 2008; 63
Gobin, Montagne, Van Zutphen, Van Der Valk, Van Den Elsen, De Groot (bb0025) 2001; 36
Zeis, Graumann, Reynolds, Schaeren-Wiemers (bb0040) 2008; 131
Theoharides, Kempuraj, Iliopoulou (bb0460) 2007; 601
Guo, Wei, Zhu, Liao, Leonard, Zhao (bb0145) 2009; 106
Luthi, Cullen, McNeela, Duriez, Afonina, Sheridan (bb0315) 2009; 31
Christophi, Panos, Hudson, Mihai, Jubelt, Massa (bb0270) 2009; 133
Gregory, Robbie-Ryan, Secor, Sabatino, Brown (bb0455) 2005; 35
Eggert, Goertsches, Seeck, Dilk, Neeck, Zettl (bb0020) 2008; 264
Theoharides, Kempuraj, Kourelis, Manola (bb0185) 2008; 1144
Massa, Wu (bb0200) 1995; 15
Christophi, Hudson, Panos, Gruber, Massa (bb0275) 2009; 83
Sayed, Walker, Brown (bb0350) 2011; 186
Joshi, Oak, Hartigan, Finn, Kunkel, Duffy (bb0375) 2010; 11
Yasuoka, Kawanokuchi, Parajuli, Jin, Doi, Noda (bb0170) 2011; 1385
Funakoshi-Tago, Tago, Hayakawa, Tominaga, Ohshio, Sonoda (bb0105) 2008; 20
Domercq, Perez-Samartin, Aparicio, Alberdi, Pampliega, Matute (bb0430) 2010; 58
Atz, Walsh, Cartagena, Li, Evans, Choudary (bb0230) 2007; 163
Yan, Greer (bb0290) 2008; 7
Iikura, Suto, Kajiwara, Oboki, Ohno, Okayama (bb0360) 2007; 87
Ohno, Oboki, Morita, Kajiwara, Arae, Tanaka (bb0280) 2011; 6
Enoksson, Lyberg, Moller-Westerberg, Fallon, Nilsson, Lunderius-Andersson (bb0450) 2011; 186
Massa, Aleyasin, Park, Mao, Barger (bb0285) 2006; 97
Xu, Jiang, Kewin, Li, Mu, Fraser (bb0345) 2008; 105
Lamkanfi, Dixit (bb0310) 2009; 31
Kanneganti, Lamkanfi, Kim, Chen, Park, Franchi (bb0440) 2007; 26
Rathinam, Jiang, Waggoner, Sharma, Cole, Waggoner (bb0410) 2010; 11
Hendriks, Teunissen, de Vries, Dijkstra (bb0065) 2005; 48
Scarisbrick, Linbo, Vandell, Keegan, Blaber, Blaber (bb0075) 2008; 389
Aoki, Hayakawa, Ozaki, Takezako, Obata, Ibaraki (bb0140) 2010; 335
Theoharides, Alysandratos, Angelidou, Delivanis, Sismanopoulos, Zhang (bb0180) 2012; 1822
Volarevic, Mitrovic, Milovanovic, Zelen, Nikolic, Mitrovic (bb0155) 2012; 56
Frisullo, Angelucci, Caggiula, Nociti, Iorio, Patanella (bb0030) 2006; 84
Noseworthy, Lucchinetti, Rodriguez, Weinshenker (bb0005) 2000; 343
Hohnoki, Inoue, Koh (bb0265) 1998; 87
Liew, Pitman, McInnes (bb0090) 2010; 10
Theoharides, Zhang, Kempuraj, Tagen, Vasiadi, Angelidou (bb0100) 2010; 107
Chang, Gusewitch, Chritton, Folz, Lebeck, Nehlsen-Cannarella (bb0205) 1993; 166
Rodriguez (bb0070) 2007; 17
De Nichilo, Burns (bb0210) 1993; 90
Sun, Ramnath, Tamizhselvi, Bhatia (bb0250) 2008; 295
Hudson, Christophi, Gruber, Wilmore, Lawrence, Massa (bb0165) 2008; 84
Krissansen, Elliott, Lucas, Stomski, Berndt, Cheresh (bb0225) 1990; 265
Dogan, Karpus (bb0055) 2004; 9
(bb0195) 1998; 352
Marina-Garcia, Franchi, Kim, Miller, McDonald, Boons (bb0435) 2008; 180
McDonald, Compston, Edan, Goodkin, Hartung, Lublin (bb0190) 2001; 50
Link (bb0260) 1998; 4
Christophi, Isackson, Blaber, Blaber, Rodriguez, Scarisbrick (bb0235) 2004; 91
Rajan, Rodriguez, Miao, Aderem (bb0420) 2011; 85
Christophi, Hudson, Gruber, Christophi, Massa (bb0220) 2008; 105
Christophi, Hudson, Gruber, Christophi, Mihai, Mejico (bb0050) 2008; 88
Stolarski, Kurowska-Stolarska, Kewin, Xu, Liew (bb0325) 2010; 185
Turnquist, Thomson (bb0135) 2009; 39
Lipton, Liang, Hertzler, Son (bb0400) 2007; 61
Karpus, Kennedy, Fife, Bennett, Dal Canto, Kunkel (bb0085) 2006; 12
Ali, Mohs, Thomas, Klare, Ross, Schmitz (bb0475) 2011; 187
Zhu, Zou, Yu, Lin, He (bb0245) 2006; 3
Louten, Rankin, Li, Murphy, Beaumont, Moon (bb0330) 2011; 23
Chang, Kim, Albacker, Baumgarth, McKenzie, Smith (bb0395) 2011; 12
Pang, Iwasaki (bb0415) 2011; 32
Ubogu, Cossoy, Ransohoff (bb0060) 2006; 27
Scarisbrick, Blaber, Lucchinetti, Genain, Blaber, Rodriguez (bb0080) 2002; 125
Kurowska-Stolarska, Stolarski, Kewin, Murphy, Corrigan, Ying (bb0380) 2009; 183
Andre, Lerouet, Kimber, Pinteaux, Rothwell (bb0385) 2005; 95
Hermans, Stinissen, Hauben, Van den Berg-Loonen, Raus, Zhang (bb0335) 1997; 42
Poeck, Bscheider, Gross, Finger, Roth, Rebsamen (bb0405) 2010; 11
Smith (bb0160) 2010; 89
Blystone, Graham, Lindberg, Brown (bb0215) 1994; 127
Cannella, Raine (bb0045) 2004; 55
Christophi, Panos, Hudson, Christophi, Gruber, Mersich (bb0370) 2009; 89
Schmitz, Owyang, Oldham, Song, Murphy, McClanahan (bb0115) 2005; 23
Lamkanfi, Dixit (bb0305) 2011; 187
Oboki, Nakae, Matsumoto, Saito (bb0320) 2011; 3
Komai-Koma, Xu, Li, McKenzie, McInnes, Liew (bb0355) 2007; 37
Allakhverdi, Smith, Comeau, Delespesse (bb0445) 2007; 179
Gross, Thomas, Guarda, Tschopp (bb0300) 2011; 243
Kornek, Lassmann (bb0015) 2003; 61
Cannella, Raine (bb0465) 1995; 37
Renard, Ernest, Houbion, Art, Le Calvez, Raes (bb0240) 2001; 29
Espinassous, Garcia-de-Paco, Garcia-Verdugo, Synguelakis, von Aulock, Sallenave (bb0130) 2009; 183
Nile, Barksby, Jitprasertwong, Preshaw, Taylor (bb0470) 2010; 130
Funakoshi-Tago, Tago, Sato, Tominaga, Kasahara (bb0125) 2011; 23
Oboki, Ohno, Kajiwara, Arae, Morita, Ishii (bb0150) 2010; 107
Nile, Barksby, Jitprasertwong, Preshaw, Taylor (bb0120) 2010; 130
Zhang, Lu, Zhao, Pflugfelder, Li (bb0110) 2011; 43
Delarasse, Gonnord, Galante, Auger, Daniel, Motta (bb0425) 2009; 109
De Nichilo (10.1016/j.clim.2011.11.007_bb0210) 1993; 90
Blystone (10.1016/j.clim.2011.11.007_bb0215) 1994; 127
Rodriguez (10.1016/j.clim.2011.11.007_bb0070) 2007; 17
Joshi (10.1016/j.clim.2011.11.007_bb0375) 2010; 11
Cannella (10.1016/j.clim.2011.11.007_bb0045) 2004; 55
Zhu (10.1016/j.clim.2011.11.007_bb0245) 2006; 3
Smith (10.1016/j.clim.2011.11.007_bb0160) 2010; 89
Christophi (10.1016/j.clim.2011.11.007_bb0275) 2009; 83
Secor (10.1016/j.clim.2011.11.007_bb0340) 2000; 191
Gregory (10.1016/j.clim.2011.11.007_bb0455) 2005; 35
Link (10.1016/j.clim.2011.11.007_bb0260) 1998; 4
McDonald (10.1016/j.clim.2011.11.007_bb0190) 2001; 50
Eggert (10.1016/j.clim.2011.11.007_bb0020) 2008; 264
Sayed (10.1016/j.clim.2011.11.007_bb0350) 2011; 186
Jack (10.1016/j.clim.2011.11.007_bb0390) 2005; 81
Delarasse (10.1016/j.clim.2011.11.007_bb0425) 2009; 109
Noseworthy (10.1016/j.clim.2011.11.007_bb0005) 2000; 343
Zhang (10.1016/j.clim.2011.11.007_bb0110) 2011; 43
Aoki (10.1016/j.clim.2011.11.007_bb0140) 2010; 335
Gross (10.1016/j.clim.2011.11.007_bb0300) 2011; 243
Luthi (10.1016/j.clim.2011.11.007_bb0315) 2009; 31
Cannella (10.1016/j.clim.2011.11.007_bb0465) 1995; 37
Theoharides (10.1016/j.clim.2011.11.007_bb0180) 2012; 1822
Chang (10.1016/j.clim.2011.11.007_bb0205) 1993; 166
Hermans (10.1016/j.clim.2011.11.007_bb0335) 1997; 42
Theoharides (10.1016/j.clim.2011.11.007_bb0185) 2008; 1144
Chakraborty (10.1016/j.clim.2011.11.007_bb0175) 2010; 88
Guo (10.1016/j.clim.2011.11.007_bb0145) 2009; 106
Lucchinetti (10.1016/j.clim.2011.11.007_bb0010) 2000; 47
Scarisbrick (10.1016/j.clim.2011.11.007_bb0075) 2008; 389
Christophi (10.1016/j.clim.2011.11.007_bb0270) 2009; 133
Hendriks (10.1016/j.clim.2011.11.007_bb0065) 2005; 48
Hudson (10.1016/j.clim.2011.11.007_bb0165) 2008; 84
Nile (10.1016/j.clim.2011.11.007_bb0470) 2010; 130
Ali (10.1016/j.clim.2011.11.007_bb0475) 2011; 187
Massa (10.1016/j.clim.2011.11.007_bb0255) 1998; 18
Schmitz (10.1016/j.clim.2011.11.007_bb0115) 2005; 23
Domercq (10.1016/j.clim.2011.11.007_bb0430) 2010; 58
Ohno (10.1016/j.clim.2011.11.007_bb0280) 2011; 6
Hohnoki (10.1016/j.clim.2011.11.007_bb0265) 1998; 87
Zeis (10.1016/j.clim.2011.11.007_bb0040) 2008; 131
Nile (10.1016/j.clim.2011.11.007_bb0120) 2010; 130
Gobin (10.1016/j.clim.2011.11.007_bb0025) 2001; 36
Sun (10.1016/j.clim.2011.11.007_bb0250) 2008; 295
Massa (10.1016/j.clim.2011.11.007_bb0285) 2006; 97
Lipton (10.1016/j.clim.2011.11.007_bb0400) 2007; 61
Funakoshi-Tago (10.1016/j.clim.2011.11.007_bb0105) 2008; 20
Chang (10.1016/j.clim.2011.11.007_bb0395) 2011; 12
Krissansen (10.1016/j.clim.2011.11.007_bb0225) 1990; 265
Christophi (10.1016/j.clim.2011.11.007_bb0370) 2009; 89
Marina-Garcia (10.1016/j.clim.2011.11.007_bb0435) 2008; 180
Dogan (10.1016/j.clim.2011.11.007_bb0055) 2004; 9
Stolarski (10.1016/j.clim.2011.11.007_bb0325) 2010; 185
Rathinam (10.1016/j.clim.2011.11.007_bb0410) 2010; 11
Scarisbrick (10.1016/j.clim.2011.11.007_bb0080) 2002; 125
Komai-Koma (10.1016/j.clim.2011.11.007_bb0355) 2007; 37
Kornek (10.1016/j.clim.2011.11.007_bb0015) 2003; 61
Theoharides (10.1016/j.clim.2011.11.007_bb0460) 2007; 601
(10.1016/j.clim.2011.11.007_bb0195) 1998; 352
Xu (10.1016/j.clim.2011.11.007_bb0345) 2008; 105
Poeck (10.1016/j.clim.2011.11.007_bb0405) 2010; 11
Breij (10.1016/j.clim.2011.11.007_bb0365) 2008; 63
Ubogu (10.1016/j.clim.2011.11.007_bb0060) 2006; 27
Oboki (10.1016/j.clim.2011.11.007_bb0150) 2010; 107
Liew (10.1016/j.clim.2011.11.007_bb0090) 2010; 10
Atz (10.1016/j.clim.2011.11.007_bb0230) 2007; 163
Allakhverdi (10.1016/j.clim.2011.11.007_bb0445) 2007; 179
Feng (10.1016/j.clim.2011.11.007_bb0035) 2002; 129
Oboki (10.1016/j.clim.2011.11.007_bb0320) 2011; 3
Funakoshi-Tago (10.1016/j.clim.2011.11.007_bb0125) 2011; 23
Christophi (10.1016/j.clim.2011.11.007_bb0220) 2008; 105
Kurowska-Stolarska (10.1016/j.clim.2011.11.007_bb0380) 2009; 183
Yan (10.1016/j.clim.2011.11.007_bb0290) 2008; 7
Espinassous (10.1016/j.clim.2011.11.007_bb0130) 2009; 183
Andre (10.1016/j.clim.2011.11.007_bb0385) 2005; 95
Lamkanfi (10.1016/j.clim.2011.11.007_bb0310) 2009; 31
Turnquist (10.1016/j.clim.2011.11.007_bb0135) 2009; 39
Karpus (10.1016/j.clim.2011.11.007_bb0085) 2006; 12
Massa (10.1016/j.clim.2011.11.007_bb0200) 1995; 15
Frisullo (10.1016/j.clim.2011.11.007_bb0030) 2006; 84
Renard (10.1016/j.clim.2011.11.007_bb0240) 2001; 29
Yasuoka (10.1016/j.clim.2011.11.007_bb0170) 2011; 1385
Kurowska-Stolarska (10.1016/j.clim.2011.11.007_bb0095) 2011; 269
Christophi (10.1016/j.clim.2011.11.007_bb0050) 2008; 88
Christophi (10.1016/j.clim.2011.11.007_bb0235) 2004; 91
Enoksson (10.1016/j.clim.2011.11.007_bb0450) 2011; 186
Theoharides (10.1016/j.clim.2011.11.007_bb0100) 2010; 107
Iikura (10.1016/j.clim.2011.11.007_bb0360) 2007; 87
Louten (10.1016/j.clim.2011.11.007_bb0330) 2011; 23
Kanneganti (10.1016/j.clim.2011.11.007_bb0440) 2007; 26
Volarevic (10.1016/j.clim.2011.11.007_bb0155) 2012; 56
Pang (10.1016/j.clim.2011.11.007_bb0415) 2011; 32
Lamkanfi (10.1016/j.clim.2011.11.007_bb0305) 2011; 187
Rajan (10.1016/j.clim.2011.11.007_bb0420) 2011; 85
References_xml – volume: 43
  start-page: 1383
  year: 2011
  end-page: 1391
  ident: bb0110
  article-title: TLR-mediated induction of pro-allergic cytokine IL-33 in ocular mucosal epithelium
  publication-title: Int. J. Biochem. Cell Biol.
– volume: 31
  start-page: 5
  year: 2009
  end-page: 7
  ident: bb0310
  article-title: IL-33 raises alarm
  publication-title: Immunity
– volume: 107
  start-page: 4448
  year: 2010
  end-page: 4453
  ident: bb0100
  article-title: IL-33 augments substance P-induced VEGF secretion from human mast cells and is increased in psoriatic skin
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 601
  start-page: 423
  year: 2007
  end-page: 430
  ident: bb0460
  article-title: Mast cells, T cells, and inhibition by luteolin: implications for the pathogenesis and treatment of multiple sclerosis
  publication-title: Adv. Exp. Med. Biol.
– volume: 163
  start-page: 295
  year: 2007
  end-page: 309
  ident: bb0230
  article-title: Methodological considerations for gene expression profiling of human brain
  publication-title: J. Neurosci. Methods
– volume: 185
  start-page: 3472
  year: 2010
  end-page: 3480
  ident: bb0325
  article-title: IL-33 exacerbates eosinophil-mediated airway inflammation
  publication-title: J. Immunol.
– volume: 166
  start-page: 45
  year: 1993
  end-page: 54
  ident: bb0205
  article-title: Rapid flow cytometric assay for the assessment of natural killer cell activity
  publication-title: J. Immunol. Methods
– volume: 88
  start-page: 243
  year: 2008
  end-page: 255
  ident: bb0050
  article-title: SHP-1 deficiency and increased inflammatory gene expression in PBMCs of multiple sclerosis patients
  publication-title: Lab. Invest.
– volume: 133
  start-page: 27
  year: 2009
  end-page: 44
  ident: bb0270
  article-title: Interferon-b treatment in multiple sclerosis attenuates inflammatory gene expression through inducible activity of the phosphatase SHP-1
  publication-title: Clin. Immunol.
– volume: 352
  start-page: 1498
  year: 1998
  end-page: 1504
  ident: bb0195
  article-title: Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis. PRISMS (Prevention of Relapses and Disability by Interferon beta-1a Subcutaneously in Multiple Sclerosis) Study Group
  publication-title: Lancet
– volume: 20
  start-page: 1679
  year: 2008
  end-page: 1686
  ident: bb0105
  article-title: TRAF6 is a critical signal transducer in IL-33 signaling pathway
  publication-title: Cell. Signal.
– volume: 1385
  start-page: 8
  year: 2011
  end-page: 17
  ident: bb0170
  article-title: Production and functions of IL-33 in the central nervous system
  publication-title: Brain Res.
– volume: 295
  start-page: C679
  year: 2008
  end-page: C691
  ident: bb0250
  article-title: Neurokinin A engages neurokinin-1 receptor to induce NF-kappaB-dependent gene expression in murine macrophages: implications of ERK1/2 and PI 3-kinase/Akt pathways
  publication-title: Am. J. Physiol. Cell Physiol.
– volume: 191
  start-page: 813
  year: 2000
  end-page: 822
  ident: bb0340
  article-title: Mast cells are essential for early onset and severe disease in a murine model of multiple sclerosis
  publication-title: J. Exp. Med.
– volume: 343
  start-page: 938
  year: 2000
  end-page: 952
  ident: bb0005
  article-title: Multiple sclerosis
  publication-title: N. Engl. J. Med.
– volume: 105
  start-page: 10913
  year: 2008
  end-page: 10918
  ident: bb0345
  article-title: IL-33 exacerbates antigen-induced arthritis by activating mast cells
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 10
  start-page: 103
  year: 2010
  end-page: 110
  ident: bb0090
  article-title: Disease-associated functions of IL-33: the new kid in the IL-1 family
  publication-title: Nat. Rev. Immunol.
– volume: 107
  start-page: 18581
  year: 2010
  end-page: 18586
  ident: bb0150
  article-title: IL-33 is a crucial amplifier of innate rather than acquired immunity
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 7
  start-page: 536
  year: 2008
  end-page: 557
  ident: bb0290
  article-title: NF-kappa B, a potential therapeutic target for the treatment of multiple sclerosis
  publication-title: CNS Neurol. Disord. Drug Targets
– volume: 56
  start-page: 26
  year: 2012
  end-page: 33
  ident: bb0155
  article-title: Protective role of IL-33/ST2 axis in Con A-induced hepatitis
  publication-title: J. Hepatol.
– volume: 12
  start-page: 631
  year: 2011
  end-page: 638
  ident: bb0395
  article-title: Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity
  publication-title: Nat. Immunol.
– volume: 125
  start-page: 1283
  year: 2002
  end-page: 1296
  ident: bb0080
  article-title: Activity of a newly identified serine protease in CNS demyelination
  publication-title: Brain
– volume: 11
  start-page: 52
  year: 2010
  ident: bb0375
  article-title: Interleukin-33 contributes to both M1 and M2 chemokine marker expression in human macrophages
  publication-title: BMC Immunol.
– volume: 243
  start-page: 136
  year: 2011
  end-page: 151
  ident: bb0300
  article-title: The inflammasome: an integrated view
  publication-title: Immunol. Rev.
– volume: 11
  start-page: 395
  year: 2010
  end-page: 402
  ident: bb0410
  article-title: The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses
  publication-title: Nat. Immunol.
– volume: 48
  start-page: 185
  year: 2005
  end-page: 195
  ident: bb0065
  article-title: Macrophages and neurodegeneration
  publication-title: Brain Res. Brain Res. Rev.
– volume: 29
  start-page: E21
  year: 2001
  ident: bb0240
  article-title: Development of a sensitive multi-well colorimetric assay for active NFkappaB
  publication-title: Nucleic Acids Res.
– volume: 129
  start-page: 205
  year: 2002
  end-page: 215
  ident: bb0035
  article-title: Low expression of interferon-stimulated genes in active multiple sclerosis is linked to subnormal phosphorylation of STAT1
  publication-title: J. Neuroimmunol.
– volume: 106
  start-page: 13463
  year: 2009
  end-page: 13468
  ident: bb0145
  article-title: IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 31
  start-page: 84
  year: 2009
  end-page: 98
  ident: bb0315
  article-title: Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases
  publication-title: Immunity
– volume: 179
  start-page: 2051
  year: 2007
  end-page: 2054
  ident: bb0445
  article-title: Cutting edge: the ST2 ligand IL-33 potently activates and drives maturation of human mast cells
  publication-title: J. Immunol.
– volume: 264
  start-page: 145
  year: 2008
  end-page: 150
  ident: bb0020
  article-title: Changes in the activation level of NF-kappa B in lymphocytes of MS patients during glucocorticoid pulse therapy
  publication-title: J. Neurol. Sci.
– volume: 1144
  start-page: 74
  year: 2008
  end-page: 82
  ident: bb0185
  article-title: Human mast cells stimulate activated T cells: implications for multiple sclerosis
  publication-title: Ann. N. Y. Acad. Sci.
– volume: 269
  start-page: 29
  year: 2011
  end-page: 35
  ident: bb0095
  article-title: Interleukin-33: a novel mediator with a role in distinct disease pathologies
  publication-title: J. Intern. Med.
– volume: 91
  start-page: 1439
  year: 2004
  end-page: 1449
  ident: bb0235
  article-title: Distinct promoters regulate tissue-specific and differential expression of kallikrein 6 in CNS demyelinating disease
  publication-title: J. Neurochem.
– volume: 81
  start-page: 363
  year: 2005
  end-page: 373
  ident: bb0390
  article-title: Microglia and multiple sclerosis
  publication-title: J. Neurosci. Res.
– volume: 265
  start-page: 823
  year: 1990
  end-page: 830
  ident: bb0225
  article-title: Identification of a novel integrin beta subunit expressed on cultured monocytes (macrophages). Evidence that one alpha subunit can associate with multiple beta subunits
  publication-title: J. Biol. Chem.
– volume: 39
  start-page: 3292
  year: 2009
  end-page: 3295
  ident: bb0135
  article-title: IL-33 broadens its repertoire to affect DC
  publication-title: Eur. J. Immunol.
– volume: 183
  start-page: 6469
  year: 2009
  end-page: 6477
  ident: bb0380
  article-title: IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation
  publication-title: J. Immunol.
– volume: 90
  start-page: 2517
  year: 1993
  end-page: 2521
  ident: bb0210
  article-title: Granulocyte-macrophage and macrophage colony-stimulating factors differentially regulate alpha v integrin expression on cultured human macrophages
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 32
  start-page: 34
  year: 2011
  end-page: 41
  ident: bb0415
  article-title: Inflammasomes as mediators of immunity against influenza virus
  publication-title: Trends Immunol.
– volume: 186
  start-page: 3294
  year: 2011
  end-page: 3298
  ident: bb0350
  article-title: Cutting edge: mast cells regulate disease severity in a relapsing–remitting model of multiple sclerosis
  publication-title: J. Immunol.
– volume: 131
  start-page: 288
  year: 2008
  end-page: 303
  ident: bb0040
  article-title: Normal-appearing white matter in multiple sclerosis is in a subtle balance between inflammation and neuroprotection
  publication-title: Brain
– volume: 83
  start-page: 522
  year: 2009
  end-page: 539
  ident: bb0275
  article-title: Modulation of macrophage infiltration and inflammatory activity by the phosphatase SHP-1 in virus-induced demyelinating disease
  publication-title: J. Virol.
– volume: 3
  start-page: 81
  year: 2011
  end-page: 88
  ident: bb0320
  article-title: IL-33 and airway inflammation
  publication-title: Allergy Asthma Immunol. Res.
– volume: 26
  start-page: 433
  year: 2007
  end-page: 443
  ident: bb0440
  article-title: Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling
  publication-title: Immunity
– volume: 6
  start-page: e18404
  year: 2011
  ident: bb0280
  article-title: Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage activation
  publication-title: PLoS One
– volume: 11
  start-page: 63
  year: 2010
  end-page: 69
  ident: bb0405
  article-title: Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production
  publication-title: Nat. Immunol.
– volume: 63
  start-page: 16
  year: 2008
  end-page: 25
  ident: bb0365
  article-title: Homogeneity of active demyelinating lesions in established multiple sclerosis
  publication-title: Ann. Neurol.
– volume: 37
  start-page: 2779
  year: 2007
  end-page: 2786
  ident: bb0355
  article-title: IL-33 is a chemoattractant for human Th2 cells
  publication-title: Eur. J. Immunol.
– volume: 87
  start-page: 971
  year: 2007
  end-page: 978
  ident: bb0360
  article-title: IL-33 can promote survival, adhesion and cytokine production in human mast cells
  publication-title: Lab. Invest.
– volume: 35
  start-page: 3478
  year: 2005
  end-page: 3486
  ident: bb0455
  article-title: Mast cells are required for optimal autoreactive T cell responses in a murine model of multiple sclerosis
  publication-title: Eur. J. Immunol.
– volume: 84
  start-page: 631
  year: 2008
  end-page: 643
  ident: bb0165
  article-title: Induction of IL-33 expression and activity in central nervous system glia
  publication-title: J. Leukoc. Biol.
– volume: 61
  start-page: 321
  year: 2003
  end-page: 326
  ident: bb0015
  article-title: Neuropathology of multiple sclerosis—new concepts
  publication-title: Brain Res. Bull.
– volume: 27
  start-page: 48
  year: 2006
  end-page: 55
  ident: bb0060
  article-title: The expression and function of chemokines involved in CNS inflammation
  publication-title: Trends Pharmacol. Sci.
– volume: 88
  start-page: 1615
  year: 2010
  end-page: 1631
  ident: bb0175
  article-title: Inflammasome signaling at the heart of central nervous system pathology
  publication-title: J. Neurosci. Res.
– volume: 186
  start-page: 2523
  year: 2011
  end-page: 2528
  ident: bb0450
  article-title: Mast cells as sensors of cell injury through IL-33 recognition
  publication-title: J. Immunol.
– volume: 335
  start-page: 75
  year: 2010
  end-page: 81
  ident: bb0140
  article-title: ST2 gene expression is proliferation-dependent and its ligand, IL-33, induces inflammatory reaction in endothelial cells
  publication-title: Mol. Cell. Biochem.
– volume: 183
  start-page: 1446
  year: 2009
  end-page: 1455
  ident: bb0130
  article-title: IL-33 enhances lipopolysaccharide-induced inflammatory cytokine production from mouse macrophages by regulating lipopolysaccharide receptor complex
  publication-title: J. Immunol.
– volume: 1822
  start-page: 21
  year: 2012
  end-page: 33
  ident: bb0180
  article-title: Mast cells and inflammation
  publication-title: Biochim. Biophys. Acta
– volume: 18
  start-page: 499
  year: 1998
  end-page: 507
  ident: bb0255
  article-title: Increased inducible activation of NF-kappaB and responsive genes in astrocytes deficient in the protein tyrosine phosphatase SHP-1
  publication-title: J. Interferon Cytokine Res.
– volume: 37
  start-page: 424
  year: 1995
  end-page: 435
  ident: bb0465
  article-title: The adhesion molecule and cytokine profile of multiple sclerosis lesions
  publication-title: Ann. Neurol.
– volume: 389
  start-page: 739
  year: 2008
  end-page: 745
  ident: bb0075
  article-title: Kallikreins are associated with secondary progressive multiple sclerosis and promote neurodegeneration
  publication-title: Biol. Chem.
– volume: 23
  start-page: 363
  year: 2011
  end-page: 370
  ident: bb0125
  article-title: JAK2 is an important signal transducer in IL-33-induced NF-kappaB activation
  publication-title: Cell. Signal.
– volume: 58
  start-page: 730
  year: 2010
  end-page: 740
  ident: bb0430
  article-title: P2X7 receptors mediate ischemic damage to oligodendrocytes
  publication-title: Glia
– volume: 89
  start-page: 383
  year: 2010
  end-page: 392
  ident: bb0160
  article-title: The biological paths of IL-1 family members IL-18 and IL-33
  publication-title: J. Leukoc. Biol.
– volume: 180
  start-page: 4050
  year: 2008
  end-page: 4057
  ident: bb0435
  article-title: Pannexin-1-mediated intracellular delivery of muramyl dipeptide induces caspase-1 activation via cryopyrin/NLRP3 independently of Nod2
  publication-title: J. Immunol.
– volume: 3
  start-page: 307
  year: 2006
  end-page: 310
  ident: bb0245
  article-title: Human recombinant PLD2 can repress p65 activity of guinea pigs of chronic asthma in vivo
  publication-title: Cell. Mol. Immunol.
– volume: 187
  start-page: 597
  year: 2011
  end-page: 602
  ident: bb0305
  article-title: Modulation of inflammasome pathways by bacterial and viral pathogens
  publication-title: J. Immunol.
– volume: 87
  start-page: 27
  year: 1998
  end-page: 32
  ident: bb0265
  article-title: Elevated serum levels of IFN-gamma, IL-4 and TNF-alpha/unelevated serum levels of IL-10 in patients with demyelinating diseases during the acute stage
  publication-title: J. Neuroimmunol.
– volume: 84
  start-page: 1027
  year: 2006
  end-page: 1036
  ident: bb0030
  article-title: pSTAT1, pSTAT3, and T-bet expression in peripheral blood mononuclear cells from relapsing–remitting multiple sclerosis patients correlates with disease activity
  publication-title: J. Neurosci. Res.
– volume: 12
  start-page: 251
  year: 2006
  end-page: 261
  ident: bb0085
  article-title: Anti-CCL2 treatment inhibits Theiler's murine encephalomyelitis virus-induced demyelinating disease
  publication-title: J. Neurovirol.
– volume: 4
  start-page: 12
  year: 1998
  end-page: 15
  ident: bb0260
  article-title: The cytokine storm in multiple sclerosis
  publication-title: Mult. Scler.
– volume: 187
  start-page: 1609
  year: 2011
  end-page: 1616
  ident: bb0475
  article-title: The dual function cytokine IL-33 interacts with the transcription factor NF-kappaB to dampen NF-kappaB-stimulated gene transcription
  publication-title: J. Immunol.
– volume: 23
  start-page: 479
  year: 2005
  end-page: 490
  ident: bb0115
  article-title: IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
  publication-title: Immunity
– volume: 55
  start-page: 46
  year: 2004
  end-page: 57
  ident: bb0045
  article-title: Multiple sclerosis: cytokine receptors on oligodendrocytes predict innate regulation
  publication-title: Ann. Neurol.
– volume: 9
  start-page: 1500
  year: 2004
  end-page: 1505
  ident: bb0055
  article-title: Chemokines and chemokine receptors in autoimmune encephalomyelitis as a model for central nervous system inflammatory disease regulation
  publication-title: Front. Biosci.
– volume: 36
  start-page: 68
  year: 2001
  end-page: 77
  ident: bb0025
  article-title: Upregulation of transcription factors controlling MHC expression in multiple sclerosis lesions
  publication-title: Glia
– volume: 23
  start-page: 307
  year: 2011
  end-page: 315
  ident: bb0330
  article-title: Endogenous IL-33 enhances Th2 cytokine production and T-cell responses during allergic airway inflammation
  publication-title: Int. Immunol.
– volume: 95
  start-page: 324
  year: 2005
  end-page: 330
  ident: bb0385
  article-title: Regulation of expression of the novel IL-1 receptor family members in the mouse brain
  publication-title: J. Neurochem.
– volume: 130
  start-page: 172
  year: 2010
  end-page: 180
  ident: bb0120
  article-title: Expression and regulation of interleukin-33 in human monocytes
  publication-title: Immunology
– volume: 109
  start-page: 846
  year: 2009
  end-page: 857
  ident: bb0425
  article-title: Neural progenitor cell death is induced by extracellular ATP via ligation of P2X7 receptor
  publication-title: J. Neurochem.
– volume: 89
  start-page: 742
  year: 2009
  end-page: 759
  ident: bb0370
  article-title: Macrophages of multiple sclerosis patients display deficient SHP-1 expression and enhanced inflammatory phenotype
  publication-title: Lab. Invest.
– volume: 61
  start-page: 514
  year: 2007
  end-page: 523
  ident: bb0400
  article-title: A specific viral cause of multiple sclerosis: one virus, one disease
  publication-title: Ann. Neurol.
– volume: 17
  start-page: 219
  year: 2007
  end-page: 229
  ident: bb0070
  article-title: Effectors of demyelination and remyelination in the CNS: implications for multiple sclerosis
  publication-title: Brain Pathol.
– volume: 127
  start-page: 1129
  year: 1994
  end-page: 1137
  ident: bb0215
  article-title: Integrin alpha v beta 3 differentially regulates adhesive and phagocytic functions of the fibronectin receptor alpha 5 beta 1
  publication-title: J. Cell Biol.
– volume: 15
  start-page: 799
  year: 1995
  end-page: 810
  ident: bb0200
  article-title: Interferon regulatory factor element and interferon regulatory factor 1 in the induction of major histocompatibility complex class I genes in neural cells
  publication-title: J. Interferon Cytokine Res.
– volume: 47
  start-page: 707
  year: 2000
  end-page: 717
  ident: bb0010
  article-title: Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination
  publication-title: Ann. Neurol.
– volume: 97
  start-page: 607
  year: 2006
  end-page: 618
  ident: bb0285
  article-title: NFkappaB in neurons? The uncertainty principle in neurobiology
  publication-title: J. Neurochem.
– volume: 105
  start-page: 2511
  year: 2008
  end-page: 2523
  ident: bb0220
  article-title: Promoter-specific induction of the phosphatase SHP-1 by viral infection and cytokines in CNS glia
  publication-title: J. Neurochem.
– volume: 85
  start-page: 4167
  year: 2011
  end-page: 4172
  ident: bb0420
  article-title: The NLRP3 inflammasome detects encephalomyocarditis virus and vesicular stomatitis virus infection
  publication-title: J. Virol.
– volume: 42
  start-page: 18
  year: 1997
  end-page: 27
  ident: bb0335
  article-title: Cytokine profile of myelin basic protein-reactive T cells in multiple sclerosis and healthy individuals
  publication-title: Ann. Neurol.
– volume: 50
  start-page: 121
  year: 2001
  end-page: 127
  ident: bb0190
  article-title: Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis
  publication-title: Ann. Neurol.
– volume: 130
  start-page: 172
  year: 2010
  end-page: 180
  ident: bb0470
  article-title: Expression and regulation of interleukin-33 in human monocytes
  publication-title: Immunology
– volume: 11
  start-page: 52
  year: 2010
  ident: 10.1016/j.clim.2011.11.007_bb0375
  article-title: Interleukin-33 contributes to both M1 and M2 chemokine marker expression in human macrophages
  publication-title: BMC Immunol.
  doi: 10.1186/1471-2172-11-52
– volume: 87
  start-page: 27
  issue: 1–2
  year: 1998
  ident: 10.1016/j.clim.2011.11.007_bb0265
  article-title: Elevated serum levels of IFN-gamma, IL-4 and TNF-alpha/unelevated serum levels of IL-10 in patients with demyelinating diseases during the acute stage
  publication-title: J. Neuroimmunol.
  doi: 10.1016/S0165-5728(98)00053-8
– volume: 37
  start-page: 424
  year: 1995
  ident: 10.1016/j.clim.2011.11.007_bb0465
  article-title: The adhesion molecule and cytokine profile of multiple sclerosis lesions
  publication-title: Ann. Neurol.
  doi: 10.1002/ana.410370404
– volume: 31
  start-page: 5
  issue: 1
  year: 2009
  ident: 10.1016/j.clim.2011.11.007_bb0310
  article-title: IL-33 raises alarm
  publication-title: Immunity
  doi: 10.1016/j.immuni.2009.06.011
– volume: 88
  start-page: 243
  issue: 3
  year: 2008
  ident: 10.1016/j.clim.2011.11.007_bb0050
  article-title: SHP-1 deficiency and increased inflammatory gene expression in PBMCs of multiple sclerosis patients
  publication-title: Lab. Invest.
  doi: 10.1038/labinvest.3700720
– volume: 26
  start-page: 433
  issue: 4
  year: 2007
  ident: 10.1016/j.clim.2011.11.007_bb0440
  article-title: Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling
  publication-title: Immunity
  doi: 10.1016/j.immuni.2007.03.008
– volume: 12
  start-page: 251
  issue: 4
  year: 2006
  ident: 10.1016/j.clim.2011.11.007_bb0085
  article-title: Anti-CCL2 treatment inhibits Theiler's murine encephalomyelitis virus-induced demyelinating disease
  publication-title: J. Neurovirol.
  doi: 10.1080/13550280600873819
– volume: 186
  start-page: 3294
  issue: 6
  year: 2011
  ident: 10.1016/j.clim.2011.11.007_bb0350
  article-title: Cutting edge: mast cells regulate disease severity in a relapsing–remitting model of multiple sclerosis
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1003574
– volume: 107
  start-page: 4448
  issue: 9
  year: 2010
  ident: 10.1016/j.clim.2011.11.007_bb0100
  article-title: IL-33 augments substance P-induced VEGF secretion from human mast cells and is increased in psoriatic skin
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.1000803107
– volume: 3
  start-page: 307
  issue: 4
  year: 2006
  ident: 10.1016/j.clim.2011.11.007_bb0245
  article-title: Human recombinant PLD2 can repress p65 activity of guinea pigs of chronic asthma in vivo
  publication-title: Cell. Mol. Immunol.
– volume: 47
  start-page: 707
  issue: 6
  year: 2000
  ident: 10.1016/j.clim.2011.11.007_bb0010
  article-title: Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination
  publication-title: Ann. Neurol.
  doi: 10.1002/1531-8249(200006)47:6<707::AID-ANA3>3.0.CO;2-Q
– volume: 90
  start-page: 2517
  issue: 6
  year: 1993
  ident: 10.1016/j.clim.2011.11.007_bb0210
  article-title: Granulocyte-macrophage and macrophage colony-stimulating factors differentially regulate alpha v integrin expression on cultured human macrophages
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.90.6.2517
– volume: 81
  start-page: 363
  issue: 3
  year: 2005
  ident: 10.1016/j.clim.2011.11.007_bb0390
  article-title: Microglia and multiple sclerosis
  publication-title: J. Neurosci. Res.
  doi: 10.1002/jnr.20482
– volume: 37
  start-page: 2779
  issue: 10
  year: 2007
  ident: 10.1016/j.clim.2011.11.007_bb0355
  article-title: IL-33 is a chemoattractant for human Th2 cells
  publication-title: Eur. J. Immunol.
  doi: 10.1002/eji.200737547
– volume: 1822
  start-page: 21
  year: 2012
  ident: 10.1016/j.clim.2011.11.007_bb0180
  article-title: Mast cells and inflammation
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbadis.2010.12.014
– volume: 61
  start-page: 514
  issue: 6
  year: 2007
  ident: 10.1016/j.clim.2011.11.007_bb0400
  article-title: A specific viral cause of multiple sclerosis: one virus, one disease
  publication-title: Ann. Neurol.
  doi: 10.1002/ana.21116
– volume: 105
  start-page: 10913
  issue: 31
  year: 2008
  ident: 10.1016/j.clim.2011.11.007_bb0345
  article-title: IL-33 exacerbates antigen-induced arthritis by activating mast cells
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.0801898105
– volume: 185
  start-page: 3472
  issue: 6
  year: 2010
  ident: 10.1016/j.clim.2011.11.007_bb0325
  article-title: IL-33 exacerbates eosinophil-mediated airway inflammation
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1000730
– volume: 7
  start-page: 536
  issue: 6
  year: 2008
  ident: 10.1016/j.clim.2011.11.007_bb0290
  article-title: NF-kappa B, a potential therapeutic target for the treatment of multiple sclerosis
  publication-title: CNS Neurol. Disord. Drug Targets
  doi: 10.2174/187152708787122941
– volume: 11
  start-page: 395
  issue: 5
  year: 2010
  ident: 10.1016/j.clim.2011.11.007_bb0410
  article-title: The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.1864
– volume: 269
  start-page: 29
  issue: 1
  year: 2011
  ident: 10.1016/j.clim.2011.11.007_bb0095
  article-title: Interleukin-33: a novel mediator with a role in distinct disease pathologies
  publication-title: J. Intern. Med.
  doi: 10.1111/j.1365-2796.2010.02316.x
– volume: 56
  start-page: 26
  issue: 1
  year: 2012
  ident: 10.1016/j.clim.2011.11.007_bb0155
  article-title: Protective role of IL-33/ST2 axis in Con A-induced hepatitis
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2011.03.022
– volume: 105
  start-page: 2511
  year: 2008
  ident: 10.1016/j.clim.2011.11.007_bb0220
  article-title: Promoter-specific induction of the phosphatase SHP-1 by viral infection and cytokines in CNS glia
  publication-title: J. Neurochem.
  doi: 10.1111/j.1471-4159.2008.05337.x
– volume: 601
  start-page: 423
  year: 2007
  ident: 10.1016/j.clim.2011.11.007_bb0460
  article-title: Mast cells, T cells, and inhibition by luteolin: implications for the pathogenesis and treatment of multiple sclerosis
  publication-title: Adv. Exp. Med. Biol.
  doi: 10.1007/978-0-387-72005-0_45
– volume: 389
  start-page: 739
  issue: 6
  year: 2008
  ident: 10.1016/j.clim.2011.11.007_bb0075
  article-title: Kallikreins are associated with secondary progressive multiple sclerosis and promote neurodegeneration
  publication-title: Biol. Chem.
  doi: 10.1515/BC.2008.085
– volume: 39
  start-page: 3292
  issue: 12
  year: 2009
  ident: 10.1016/j.clim.2011.11.007_bb0135
  article-title: IL-33 broadens its repertoire to affect DC
  publication-title: Eur. J. Immunol.
  doi: 10.1002/eji.200940026
– volume: 106
  start-page: 13463
  issue: 32
  year: 2009
  ident: 10.1016/j.clim.2011.11.007_bb0145
  article-title: IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.0906988106
– volume: 295
  start-page: C679
  issue: 3
  year: 2008
  ident: 10.1016/j.clim.2011.11.007_bb0250
  article-title: Neurokinin A engages neurokinin-1 receptor to induce NF-kappaB-dependent gene expression in murine macrophages: implications of ERK1/2 and PI 3-kinase/Akt pathways
  publication-title: Am. J. Physiol. Cell Physiol.
  doi: 10.1152/ajpcell.00042.2008
– volume: 61
  start-page: 321
  issue: 3
  year: 2003
  ident: 10.1016/j.clim.2011.11.007_bb0015
  article-title: Neuropathology of multiple sclerosis—new concepts
  publication-title: Brain Res. Bull.
  doi: 10.1016/S0361-9230(03)00095-9
– volume: 6
  start-page: e18404
  issue: 4
  year: 2011
  ident: 10.1016/j.clim.2011.11.007_bb0280
  article-title: Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage activation
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0018404
– volume: 87
  start-page: 971
  issue: 10
  year: 2007
  ident: 10.1016/j.clim.2011.11.007_bb0360
  article-title: IL-33 can promote survival, adhesion and cytokine production in human mast cells
  publication-title: Lab. Invest.
  doi: 10.1038/labinvest.3700663
– volume: 32
  start-page: 34
  issue: 1
  year: 2011
  ident: 10.1016/j.clim.2011.11.007_bb0415
  article-title: Inflammasomes as mediators of immunity against influenza virus
  publication-title: Trends Immunol.
  doi: 10.1016/j.it.2010.11.004
– volume: 91
  start-page: 1439
  issue: 6
  year: 2004
  ident: 10.1016/j.clim.2011.11.007_bb0235
  article-title: Distinct promoters regulate tissue-specific and differential expression of kallikrein 6 in CNS demyelinating disease
  publication-title: J. Neurochem.
  doi: 10.1111/j.1471-4159.2004.02826.x
– volume: 265
  start-page: 823
  issue: 2
  year: 1990
  ident: 10.1016/j.clim.2011.11.007_bb0225
  article-title: Identification of a novel integrin beta subunit expressed on cultured monocytes (macrophages). Evidence that one alpha subunit can associate with multiple beta subunits
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(19)40123-3
– volume: 97
  start-page: 607
  issue: 3
  year: 2006
  ident: 10.1016/j.clim.2011.11.007_bb0285
  article-title: NFkappaB in neurons? The uncertainty principle in neurobiology
  publication-title: J. Neurochem.
  doi: 10.1111/j.1471-4159.2006.03810.x
– volume: 12
  start-page: 631
  issue: 7
  year: 2011
  ident: 10.1016/j.clim.2011.11.007_bb0395
  article-title: Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2045
– volume: 133
  start-page: 27
  issue: 1
  year: 2009
  ident: 10.1016/j.clim.2011.11.007_bb0270
  article-title: Interferon-b treatment in multiple sclerosis attenuates inflammatory gene expression through inducible activity of the phosphatase SHP-1
  publication-title: Clin. Immunol.
  doi: 10.1016/j.clim.2009.05.019
– volume: 127
  start-page: 1129
  issue: 4
  year: 1994
  ident: 10.1016/j.clim.2011.11.007_bb0215
  article-title: Integrin alpha v beta 3 differentially regulates adhesive and phagocytic functions of the fibronectin receptor alpha 5 beta 1
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.127.4.1129
– volume: 84
  start-page: 631
  issue: 3
  year: 2008
  ident: 10.1016/j.clim.2011.11.007_bb0165
  article-title: Induction of IL-33 expression and activity in central nervous system glia
  publication-title: J. Leukoc. Biol.
  doi: 10.1189/jlb.1207830
– volume: 43
  start-page: 1383
  issue: 9
  year: 2011
  ident: 10.1016/j.clim.2011.11.007_bb0110
  article-title: TLR-mediated induction of pro-allergic cytokine IL-33 in ocular mucosal epithelium
  publication-title: Int. J. Biochem. Cell Biol.
  doi: 10.1016/j.biocel.2011.06.003
– volume: 42
  start-page: 18
  issue: 1
  year: 1997
  ident: 10.1016/j.clim.2011.11.007_bb0335
  article-title: Cytokine profile of myelin basic protein-reactive T cells in multiple sclerosis and healthy individuals
  publication-title: Ann. Neurol.
  doi: 10.1002/ana.410420106
– volume: 50
  start-page: 121
  issue: 1
  year: 2001
  ident: 10.1016/j.clim.2011.11.007_bb0190
  article-title: Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis
  publication-title: Ann. Neurol.
  doi: 10.1002/ana.1032
– volume: 1385
  start-page: 8
  year: 2011
  ident: 10.1016/j.clim.2011.11.007_bb0170
  article-title: Production and functions of IL-33 in the central nervous system
  publication-title: Brain Res.
  doi: 10.1016/j.brainres.2011.02.045
– volume: 243
  start-page: 136
  issue: 1
  year: 2011
  ident: 10.1016/j.clim.2011.11.007_bb0300
  article-title: The inflammasome: an integrated view
  publication-title: Immunol. Rev.
  doi: 10.1111/j.1600-065X.2011.01046.x
– volume: 131
  start-page: 288
  issue: Pt 1
  year: 2008
  ident: 10.1016/j.clim.2011.11.007_bb0040
  article-title: Normal-appearing white matter in multiple sclerosis is in a subtle balance between inflammation and neuroprotection
  publication-title: Brain
– volume: 129
  start-page: 205
  issue: 1–2
  year: 2002
  ident: 10.1016/j.clim.2011.11.007_bb0035
  article-title: Low expression of interferon-stimulated genes in active multiple sclerosis is linked to subnormal phosphorylation of STAT1
  publication-title: J. Neuroimmunol.
  doi: 10.1016/S0165-5728(02)00182-0
– volume: 85
  start-page: 4167
  issue: 9
  year: 2011
  ident: 10.1016/j.clim.2011.11.007_bb0420
  article-title: The NLRP3 inflammasome detects encephalomyocarditis virus and vesicular stomatitis virus infection
  publication-title: J. Virol.
  doi: 10.1128/JVI.01687-10
– volume: 166
  start-page: 45
  issue: 1
  year: 1993
  ident: 10.1016/j.clim.2011.11.007_bb0205
  article-title: Rapid flow cytometric assay for the assessment of natural killer cell activity
  publication-title: J. Immunol. Methods
  doi: 10.1016/0022-1759(93)90327-4
– volume: 187
  start-page: 597
  issue: 2
  year: 2011
  ident: 10.1016/j.clim.2011.11.007_bb0305
  article-title: Modulation of inflammasome pathways by bacterial and viral pathogens
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1100229
– volume: 63
  start-page: 16
  issue: 1
  year: 2008
  ident: 10.1016/j.clim.2011.11.007_bb0365
  article-title: Homogeneity of active demyelinating lesions in established multiple sclerosis
  publication-title: Ann. Neurol.
  doi: 10.1002/ana.21311
– volume: 109
  start-page: 846
  issue: 3
  year: 2009
  ident: 10.1016/j.clim.2011.11.007_bb0425
  article-title: Neural progenitor cell death is induced by extracellular ATP via ligation of P2X7 receptor
  publication-title: J. Neurochem.
  doi: 10.1111/j.1471-4159.2009.06008.x
– volume: 84
  start-page: 1027
  issue: 5
  year: 2006
  ident: 10.1016/j.clim.2011.11.007_bb0030
  article-title: pSTAT1, pSTAT3, and T-bet expression in peripheral blood mononuclear cells from relapsing–remitting multiple sclerosis patients correlates with disease activity
  publication-title: J. Neurosci. Res.
  doi: 10.1002/jnr.20995
– volume: 130
  start-page: 172
  year: 2010
  ident: 10.1016/j.clim.2011.11.007_bb0470
  article-title: Expression and regulation of interleukin-33 in human monocytes
  publication-title: Immunology
  doi: 10.1111/j.1365-2567.2009.03221.x
– volume: 9
  start-page: 1500
  year: 2004
  ident: 10.1016/j.clim.2011.11.007_bb0055
  article-title: Chemokines and chemokine receptors in autoimmune encephalomyelitis as a model for central nervous system inflammatory disease regulation
  publication-title: Front. Biosci.
  doi: 10.2741/1284
– volume: 20
  start-page: 1679
  issue: 9
  year: 2008
  ident: 10.1016/j.clim.2011.11.007_bb0105
  article-title: TRAF6 is a critical signal transducer in IL-33 signaling pathway
  publication-title: Cell. Signal.
  doi: 10.1016/j.cellsig.2008.05.013
– volume: 187
  start-page: 1609
  issue: 4
  year: 2011
  ident: 10.1016/j.clim.2011.11.007_bb0475
  article-title: The dual function cytokine IL-33 interacts with the transcription factor NF-kappaB to dampen NF-kappaB-stimulated gene transcription
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1003080
– volume: 89
  start-page: 383
  issue: 3
  year: 2010
  ident: 10.1016/j.clim.2011.11.007_bb0160
  article-title: The biological paths of IL-1 family members IL-18 and IL-33
  publication-title: J. Leukoc. Biol.
  doi: 10.1189/jlb.0810470
– volume: 352
  start-page: 1498
  issue: 9139
  year: 1998
  ident: 10.1016/j.clim.2011.11.007_bb0195
  article-title: Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis. PRISMS (Prevention of Relapses and Disability by Interferon beta-1a Subcutaneously in Multiple Sclerosis) Study Group
  publication-title: Lancet
  doi: 10.1016/S0140-6736(98)03334-0
– volume: 23
  start-page: 479
  issue: 5
  year: 2005
  ident: 10.1016/j.clim.2011.11.007_bb0115
  article-title: IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
  publication-title: Immunity
  doi: 10.1016/j.immuni.2005.09.015
– volume: 191
  start-page: 813
  issue: 5
  year: 2000
  ident: 10.1016/j.clim.2011.11.007_bb0340
  article-title: Mast cells are essential for early onset and severe disease in a murine model of multiple sclerosis
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.191.5.813
– volume: 183
  start-page: 6469
  issue: 10
  year: 2009
  ident: 10.1016/j.clim.2011.11.007_bb0380
  article-title: IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.0901575
– volume: 163
  start-page: 295
  issue: 2
  year: 2007
  ident: 10.1016/j.clim.2011.11.007_bb0230
  article-title: Methodological considerations for gene expression profiling of human brain
  publication-title: J. Neurosci. Methods
  doi: 10.1016/j.jneumeth.2007.03.022
– volume: 36
  start-page: 68
  issue: 1
  year: 2001
  ident: 10.1016/j.clim.2011.11.007_bb0025
  article-title: Upregulation of transcription factors controlling MHC expression in multiple sclerosis lesions
  publication-title: Glia
  doi: 10.1002/glia.1096
– volume: 88
  start-page: 1615
  issue: 8
  year: 2010
  ident: 10.1016/j.clim.2011.11.007_bb0175
  article-title: Inflammasome signaling at the heart of central nervous system pathology
  publication-title: J. Neurosci. Res.
  doi: 10.1002/jnr.22343
– volume: 23
  start-page: 307
  issue: 5
  year: 2011
  ident: 10.1016/j.clim.2011.11.007_bb0330
  article-title: Endogenous IL-33 enhances Th2 cytokine production and T-cell responses during allergic airway inflammation
  publication-title: Int. Immunol.
  doi: 10.1093/intimm/dxr006
– volume: 83
  start-page: 522
  issue: 2
  year: 2009
  ident: 10.1016/j.clim.2011.11.007_bb0275
  article-title: Modulation of macrophage infiltration and inflammatory activity by the phosphatase SHP-1 in virus-induced demyelinating disease
  publication-title: J. Virol.
  doi: 10.1128/JVI.01210-08
– volume: 11
  start-page: 63
  issue: 1
  year: 2010
  ident: 10.1016/j.clim.2011.11.007_bb0405
  article-title: Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.1824
– volume: 335
  start-page: 75
  issue: 1–2
  year: 2010
  ident: 10.1016/j.clim.2011.11.007_bb0140
  article-title: ST2 gene expression is proliferation-dependent and its ligand, IL-33, induces inflammatory reaction in endothelial cells
  publication-title: Mol. Cell. Biochem.
  doi: 10.1007/s11010-009-0244-9
– volume: 130
  start-page: 172
  issue: 2
  year: 2010
  ident: 10.1016/j.clim.2011.11.007_bb0120
  article-title: Expression and regulation of interleukin-33 in human monocytes
  publication-title: Immunology
  doi: 10.1111/j.1365-2567.2009.03221.x
– volume: 4
  start-page: 12
  issue: 1
  year: 1998
  ident: 10.1016/j.clim.2011.11.007_bb0260
  article-title: The cytokine storm in multiple sclerosis
  publication-title: Mult. Scler.
  doi: 10.1191/135245898678909141
– volume: 125
  start-page: 1283
  issue: Pt 6
  year: 2002
  ident: 10.1016/j.clim.2011.11.007_bb0080
  article-title: Activity of a newly identified serine protease in CNS demyelination
  publication-title: Brain
  doi: 10.1093/brain/awf142
– volume: 343
  start-page: 938
  issue: 13
  year: 2000
  ident: 10.1016/j.clim.2011.11.007_bb0005
  article-title: Multiple sclerosis
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJM200009283431307
– volume: 183
  start-page: 1446
  issue: 2
  year: 2009
  ident: 10.1016/j.clim.2011.11.007_bb0130
  article-title: IL-33 enhances lipopolysaccharide-induced inflammatory cytokine production from mouse macrophages by regulating lipopolysaccharide receptor complex
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.0803067
– volume: 15
  start-page: 799
  issue: 9
  year: 1995
  ident: 10.1016/j.clim.2011.11.007_bb0200
  article-title: Interferon regulatory factor element and interferon regulatory factor 1 in the induction of major histocompatibility complex class I genes in neural cells
  publication-title: J. Interferon Cytokine Res.
  doi: 10.1089/jir.1995.15.799
– volume: 95
  start-page: 324
  issue: 2
  year: 2005
  ident: 10.1016/j.clim.2011.11.007_bb0385
  article-title: Regulation of expression of the novel IL-1 receptor family members in the mouse brain
  publication-title: J. Neurochem.
  doi: 10.1111/j.1471-4159.2005.03364.x
– volume: 18
  start-page: 499
  issue: 7
  year: 1998
  ident: 10.1016/j.clim.2011.11.007_bb0255
  article-title: Increased inducible activation of NF-kappaB and responsive genes in astrocytes deficient in the protein tyrosine phosphatase SHP-1
  publication-title: J. Interferon Cytokine Res.
  doi: 10.1089/jir.1998.18.499
– volume: 89
  start-page: 742
  issue: 7
  year: 2009
  ident: 10.1016/j.clim.2011.11.007_bb0370
  article-title: Macrophages of multiple sclerosis patients display deficient SHP-1 expression and enhanced inflammatory phenotype
  publication-title: Lab. Invest.
  doi: 10.1038/labinvest.2009.32
– volume: 264
  start-page: 145
  issue: 1–2
  year: 2008
  ident: 10.1016/j.clim.2011.11.007_bb0020
  article-title: Changes in the activation level of NF-kappa B in lymphocytes of MS patients during glucocorticoid pulse therapy
  publication-title: J. Neurol. Sci.
  doi: 10.1016/j.jns.2007.08.026
– volume: 180
  start-page: 4050
  issue: 6
  year: 2008
  ident: 10.1016/j.clim.2011.11.007_bb0435
  article-title: Pannexin-1-mediated intracellular delivery of muramyl dipeptide induces caspase-1 activation via cryopyrin/NLRP3 independently of Nod2
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.180.6.4050
– volume: 179
  start-page: 2051
  issue: 4
  year: 2007
  ident: 10.1016/j.clim.2011.11.007_bb0445
  article-title: Cutting edge: the ST2 ligand IL-33 potently activates and drives maturation of human mast cells
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.179.4.2051
– volume: 27
  start-page: 48
  issue: 1
  year: 2006
  ident: 10.1016/j.clim.2011.11.007_bb0060
  article-title: The expression and function of chemokines involved in CNS inflammation
  publication-title: Trends Pharmacol. Sci.
  doi: 10.1016/j.tips.2005.11.002
– volume: 29
  start-page: E21
  issue: 4
  year: 2001
  ident: 10.1016/j.clim.2011.11.007_bb0240
  article-title: Development of a sensitive multi-well colorimetric assay for active NFkappaB
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/29.4.e21
– volume: 55
  start-page: 46
  issue: 1
  year: 2004
  ident: 10.1016/j.clim.2011.11.007_bb0045
  article-title: Multiple sclerosis: cytokine receptors on oligodendrocytes predict innate regulation
  publication-title: Ann. Neurol.
  doi: 10.1002/ana.10764
– volume: 10
  start-page: 103
  issue: 2
  year: 2010
  ident: 10.1016/j.clim.2011.11.007_bb0090
  article-title: Disease-associated functions of IL-33: the new kid in the IL-1 family
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri2692
– volume: 3
  start-page: 81
  issue: 2
  year: 2011
  ident: 10.1016/j.clim.2011.11.007_bb0320
  article-title: IL-33 and airway inflammation
  publication-title: Allergy Asthma Immunol. Res.
  doi: 10.4168/aair.2011.3.2.81
– volume: 23
  start-page: 363
  issue: 2
  year: 2011
  ident: 10.1016/j.clim.2011.11.007_bb0125
  article-title: JAK2 is an important signal transducer in IL-33-induced NF-kappaB activation
  publication-title: Cell. Signal.
  doi: 10.1016/j.cellsig.2010.10.006
– volume: 35
  start-page: 3478
  issue: 12
  year: 2005
  ident: 10.1016/j.clim.2011.11.007_bb0455
  article-title: Mast cells are required for optimal autoreactive T cell responses in a murine model of multiple sclerosis
  publication-title: Eur. J. Immunol.
  doi: 10.1002/eji.200535271
– volume: 17
  start-page: 219
  issue: 2
  year: 2007
  ident: 10.1016/j.clim.2011.11.007_bb0070
  article-title: Effectors of demyelination and remyelination in the CNS: implications for multiple sclerosis
  publication-title: Brain Pathol.
  doi: 10.1111/j.1750-3639.2007.00065.x
– volume: 186
  start-page: 2523
  issue: 4
  year: 2011
  ident: 10.1016/j.clim.2011.11.007_bb0450
  article-title: Mast cells as sensors of cell injury through IL-33 recognition
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1003383
– volume: 107
  start-page: 18581
  issue: 43
  year: 2010
  ident: 10.1016/j.clim.2011.11.007_bb0150
  article-title: IL-33 is a crucial amplifier of innate rather than acquired immunity
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.1003059107
– volume: 1144
  start-page: 74
  year: 2008
  ident: 10.1016/j.clim.2011.11.007_bb0185
  article-title: Human mast cells stimulate activated T cells: implications for multiple sclerosis
  publication-title: Ann. N. Y. Acad. Sci.
  doi: 10.1196/annals.1418.029
– volume: 31
  start-page: 84
  issue: 1
  year: 2009
  ident: 10.1016/j.clim.2011.11.007_bb0315
  article-title: Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases
  publication-title: Immunity
  doi: 10.1016/j.immuni.2009.05.007
– volume: 58
  start-page: 730
  issue: 6
  year: 2010
  ident: 10.1016/j.clim.2011.11.007_bb0430
  article-title: P2X7 receptors mediate ischemic damage to oligodendrocytes
  publication-title: Glia
  doi: 10.1002/glia.20958
– volume: 48
  start-page: 185
  issue: 2
  year: 2005
  ident: 10.1016/j.clim.2011.11.007_bb0065
  article-title: Macrophages and neurodegeneration
  publication-title: Brain Res. Brain Res. Rev.
  doi: 10.1016/j.brainresrev.2004.12.008
SSID ssj0005226
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Snippet Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system (CNS). Here we document for the first time that the cytokine...
Abstract Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system (CNS). Here we document for the first time that the...
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pubmed
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SourceType Open Access Repository
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StartPage 308
SubjectTerms Adult
Allergy and Immunology
Astrocytes
Autoimmunity
Biological and medical sciences
Cells, Cultured
Central Nervous System - immunology
Demyelination
EAE
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
IL-33
Inflammation
Interleukin-33
Interleukins - immunology
Lymphocytes - immunology
Macrophages - immunology
Male
Medical sciences
Middle Aged
Multiple Sclerosis - immunology
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
NF-kappa B - immunology
Up-Regulation
Title Interleukin-33 upregulation in peripheral leukocytes and CNS of multiple sclerosis patients
URI https://www.clinicalkey.com/#!/content/1-s2.0-S1521661611003366
https://www.clinicalkey.es/playcontent/1-s2.0-S1521661611003366
https://dx.doi.org/10.1016/j.clim.2011.11.007
https://www.ncbi.nlm.nih.gov/pubmed/22189043
https://www.proquest.com/docview/923951960
https://pubmed.ncbi.nlm.nih.gov/PMC3288946
Volume 142
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