Modulation of Endothelial Function by TMAO, a Gut Microbiota-Derived Metabolite

• Published in: International journal of molecular sciences Vol. 24; no. 6; p. 5806
• Main Authors: Querio, Giulia, Antoniotti, Susanna, Geddo, Federica, Levi, Renzo, Gallo, Maria Pia
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.03.2023; MDPI
• Subjects: angiocrine factors; Arteriosclerosis; Atherosclerosis; B cells; Cytokines; Diet; Endothelium; Enzymes; Exercise; Gastrointestinal Microbiome - physiology; Growth factors; gut microbiota; Homeostasis; Humans; Inflammation; Inflammatory response; Influence; Intercellular adhesion molecule 1; Interleukin 6; Intestinal microflora; Metabolites; Methylamines - metabolism; Microbiota; Microbiota (Symbiotic organisms); Nitric oxide; Phosphorylation; Review; Selectins; Smooth muscle; TMAO; Trimethylamine; Vascular cell adhesion molecule 1; Vascular Diseases; vascular function; TMAO; endothelium; vascular function; angiocrine factors; gut microbiota

Endothelial function is essential in the maintenance of systemic homeostasis, whose modulation strictly depends on the proper activity of tissue-specific angiocrine factors on the physiopathological mechanisms acting at both single and multi-organ levels. Several angiocrine factors take part in the...