Integration of Mendelian Randomization to explore the genetic influences of pediatric sepsis: a focus on RGL4, ATP9A, MAP3K7CL, and DDX11L2

• Published in: BMC pediatrics Vol. 25; no. 1; pp. 66 - 11
• Main Authors: Zhang, Liuzhao, Chu, Quanwang, Jiang, Shuyue, Shao, Bo
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 27.01.2025; BioMed Central; BMC
• Subjects: Analysis; ATP9A; Biomarkers; Child; Child, Preschool; Datasets; DEAD-box RNA Helicases - genetics; Demographic aspects; Differential expression analysis; Female; Gene expression; Genetic aspects; Genetic markers; Genetic Predisposition to Disease; Genomes; Genomics; GTPase-Activating Proteins - genetics; Humans; Immune response; Immune system; Infections; Inflammation; Influence; Male; MAP3K7CL; Mendelian Randomization; Mendelian Randomization Analysis; Mitochondrial Proton-Translocating ATPases - genetics; Pathogens; Pathophysiology; Pediatric sepsis; Pediatrics; Polymorphism, Single Nucleotide; RGL4; Risk factors; Sepsis; Sepsis - genetics; Sepsis - immunology; China; Immune cell infiltration; Differential expression analysis; MAP3K7CL; Mendelian Randomization; Pediatric sepsis; RGL4; ATP9A; DDX11L2

This study aims to explore the genetic characteristics of pediatric sepsis through a combined analysis of multiple methods, including Mendelian Randomization (MR), differential gene expression analysis, and immune cell infiltration assessment. It explores their potential as biomarkers for sepsis ris...