Circular RNA Expression: Its Potential Regulation and Function

• Published in: Trends in genetics Vol. 32; no. 5; pp. 309 - 316
• Main Author: Salzman, Julia
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.05.2016
• Subjects: circRNA; circular RNA; Gene Expression Regulation; Humans; Medical Education; RNA; RNA - biosynthesis; RNA - genetics; RNA splicing; RNA Splicing - genetics; RNA; circRNA; circular RNA; RNA splicing

In 2012, a new feature of eukaryotic gene expression emerged: ubiquitous expression of circular RNA (circRNA) from genes traditionally thought to express messenger or linear noncoding (nc)RNA only. CircRNAs are covalently closed, circular RNA molecules that typically comprise exonic sequences and ar...