Circular RNA Expression: Its Potential Regulation and Function

In 2012, a new feature of eukaryotic gene expression emerged: ubiquitous expression of circular RNA (circRNA) from genes traditionally thought to express messenger or linear noncoding (nc)RNA only. CircRNAs are covalently closed, circular RNA molecules that typically comprise exonic sequences and ar...

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Bibliographic Details
Published in	Trends in genetics Vol. 32; no. 5; pp. 309 - 316
Main Author	Salzman, Julia
Format	Journal Article
Language	English
Published	England Elsevier Ltd 01.05.2016
Subjects	circRNA circular RNA Gene Expression Regulation Humans Medical Education RNA RNA - biosynthesis RNA - genetics RNA splicing RNA Splicing - genetics RNA circRNA circular RNA RNA splicing
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Abstract	In 2012, a new feature of eukaryotic gene expression emerged: ubiquitous expression of circular RNA (circRNA) from genes traditionally thought to express messenger or linear noncoding (nc)RNA only. CircRNAs are covalently closed, circular RNA molecules that typically comprise exonic sequences and are spliced at canonical splice sites. This feature of gene expression was first recognized in humans and mouse, but it quickly emerged that it was common across essentially all eukaryotes studied by molecular biologists. CircRNA abundance, and even which alternatively spliced circRNA isoforms are expressed, varies by cell type and can exceed the abundance of the traditional linear mRNA or ncRNA transcript. CircRNAs are enriched in the brain and increase in abundance during fetal development. Together, these features raise fundamental questions regarding the regulation of circRNA in cis and in trans, and its function. Many circRNAs have recently been discovered and characterized. Recently, much light has been shed on the regulation and function of circRNAs CircRNA has been posited to function as a miRNA or RNA-binding protein sponge. However, a general function has not been identified. Developmental regulation of circRNA and enrichment in the nervous system are an emerging theme shared by circRNAs across the metazoan lineage, from flies to humans. CircRNAs can be joined by 3′–5′ linkages, containing only exonic sequence; 2′–5′ linkages (intronic lariats); or 3′–5′ linkages that contain retained intronic sequences.
AbstractList	In 2012, a new feature of eukaryotic gene expression emerged: ubiquitous expression of circular RNA (circRNA) from genes traditionally thought to express messenger or linear noncoding (nc)RNA only. CircRNAs are covalently closed, circular RNA molecules that typically comprise exonic sequences and are spliced at canonical splice sites. This feature of gene expression was first recognized in humans and mouse, but it quickly emerged that it was common across essentially all eukaryotes studied by molecular biologists. CircRNA abundance, and even which alternatively spliced circRNA isoforms are expressed, varies by cell type and can exceed the abundance of the traditional linear mRNA or ncRNA transcript. CircRNAs are enriched in the brain and increase in abundance during fetal development. Together, these features raise fundamental questions regarding the regulation of circRNA in cis and in trans, and its function.In 2012, a new feature of eukaryotic gene expression emerged: ubiquitous expression of circular RNA (circRNA) from genes traditionally thought to express messenger or linear noncoding (nc)RNA only. CircRNAs are covalently closed, circular RNA molecules that typically comprise exonic sequences and are spliced at canonical splice sites. This feature of gene expression was first recognized in humans and mouse, but it quickly emerged that it was common across essentially all eukaryotes studied by molecular biologists. CircRNA abundance, and even which alternatively spliced circRNA isoforms are expressed, varies by cell type and can exceed the abundance of the traditional linear mRNA or ncRNA transcript. CircRNAs are enriched in the brain and increase in abundance during fetal development. Together, these features raise fundamental questions regarding the regulation of circRNA in cis and in trans, and its function. In 2012, a new feature of eukaryotic gene expression emerged: ubiquitous expression of circular RNA (circRNA) from genes traditionally thought to express messenger or linear noncoding (nc)RNA only. CircRNAs are covalently closed, circular RNA molecules that typically comprise exonic sequences and are spliced at canonical splice sites. This feature of gene expression was first recognized in humans and mouse, but it quickly emerged that it was common across essentially all eukaryotes studied by molecular biologists. CircRNA abundance, and even which alternatively spliced circRNA isoforms are expressed, varies by cell type and can exceed the abundance of the traditional linear mRNA or ncRNA transcript. CircRNAs are enriched in the brain and increase in abundance during fetal development. Together, these features raise fundamental questions regarding the regulation of circRNA in cis and in trans, and its function. Many circRNAs have recently been discovered and characterized. Recently, much light has been shed on the regulation and function of circRNAs CircRNA has been posited to function as a miRNA or RNA-binding protein sponge. However, a general function has not been identified. Developmental regulation of circRNA and enrichment in the nervous system are an emerging theme shared by circRNAs across the metazoan lineage, from flies to humans. CircRNAs can be joined by 3′–5′ linkages, containing only exonic sequence; 2′–5′ linkages (intronic lariats); or 3′–5′ linkages that contain retained intronic sequences. In 2012, a new feature of eukaryotic gene expression emerged: ubiquitous expression of circular RNA (circRNA) from genes traditionally thought to express messenger or linear noncoding (nc)RNA only. CircRNAs are covalently closed, circular RNA molecules that typically comprise exonic sequences and are spliced at canonical splice sites. This feature of gene expression was first recognized in humans and mouse, but it quickly emerged that it was common across essentially all eukaryotes studied by molecular biologists. CircRNA abundance, and even which alternatively spliced circRNA isoforms are expressed, varies by cell type and can exceed the abundance of the traditional linear mRNA or ncRNA transcript. CircRNAs are enriched in the brain and increase in abundance during fetal development. Together, these features raise fundamental questions regarding the regulation of circRNA in cis and in trans , and its function. In 2012, a new feature of eukaryotic gene expression emerged: ubiquitous expression of circular RNA (circRNA) from genes traditionally thought to express messenger or linear noncoding (nc)RNA only. CircRNAs are covalently closed, circular RNA molecules that typically comprise exonic sequences and are spliced at canonical splice sites. This feature of gene expression was first recognized in humans and mouse, but it quickly emerged that it was common across essentially all eukaryotes studied by molecular biologists. CircRNA abundance, and even which alternatively spliced circRNA isoforms are expressed, varies by cell type and can exceed the abundance of the traditional linear mRNA or ncRNA transcript. CircRNAs are enriched in the brain and increase in abundance during fetal development. Together, these features raise fundamental questions regarding the regulation of circRNA in cis and in trans, and its function.
Author	Salzman, Julia
AuthorAffiliation	1 Department of Biochemistry and Stanford Cancer Institute, Stanford University, Stanford, CA, USA
AuthorAffiliation_xml	– name: 1 Department of Biochemistry and Stanford Cancer Institute, Stanford University, Stanford, CA, USA
Author_xml	– sequence: 1 givenname: Julia surname: Salzman fullname: Salzman, Julia email: Julia.salzman@stanford.edu organization: Department of Biochemistry and Stanford Cancer Institute, Stanford University, Stanford, CA, USA
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/27050930$$D View this record in MEDLINE/PubMed
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Cites_doi	10.1261/rna.052282.115 10.1016/j.cell.2014.07.012 10.1186/s12864-015-1603-4 10.1261/rna.047126.114 10.1101/gad.270421.115 10.1146/annurev.genet.40.110405.090625 10.1016/0092-8674(93)90279-Y 10.1016/S0092-8674(00)80878-8 10.1074/jbc.274.12.8153 10.1038/nature11993 10.7150/jca.11997 10.1371/journal.pone.0090859 10.1016/j.celrep.2014.12.019 10.1182/blood-2015-06-649434 10.1186/s13059-015-0690-5 10.1016/j.molcel.2014.08.019 10.1002/j.1460-2075.1992.tb05148.x 10.1038/nature11928 10.1093/nar/24.6.1015 10.1016/j.cell.2014.09.001 10.1038/nrg3847 10.1016/j.jmb.2015.02.018 10.1038/nn.3975 10.1016/0092-8674(91)90244-S 10.1371/journal.pone.0030733 10.1101/gad.247361.114 10.1016/j.cell.2015.02.014 10.1186/s13059-014-0409-z 10.1242/dev.124.21.4321 10.1038/280339a0 10.1371/journal.pone.0141214 10.1016/j.molcel.2013.08.017 10.1186/1479-7364-8-3 10.1038/nrm3967 10.1074/jbc.M606744200 10.1016/j.celrep.2014.12.002 10.1038/cr.2015.82 10.1038/emboj.2011.359 10.1038/nbt.1883 10.1186/s13059-015-0801-3 10.1371/journal.pgen.1003777 10.1016/j.molcel.2015.03.027 10.1073/pnas.1403244111 10.1038/nbt.2890 10.7554/eLife.07540 10.1101/gad.187278.112 10.1016/j.celrep.2014.10.062 10.1371/journal.pgen.1001233 10.1128/MCB.17.6.2985 10.1146/annurev.physiol.60.1.497 10.1101/gad.251926.114 10.1371/journal.pbio.1001156 10.1095/biolreprod57.5.1128 10.1038/348450a0 10.1128/MCB.17.2.809 10.1093/jhered/esj037 10.1261/rna.035667.112 10.1093/hmg/1.5.345 10.1073/pnas.0136770100
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References	Vincent, Deutscher (bib0475) 2006; 281 Coca-Prados, Hsu (bib0380) 1979; 280 Dichmann, Harland (bib0485) 2012; 26 Saad (bib0395) 1992; 1 Conn (bib0370) 2015; 160 Grabherr (bib0460) 2011; 29 Hooper (bib0455) 2014; 8 Koopman (bib0420) 1990; 348 Starke (bib0550) 2015; 10 Begemann (bib0590) 1997; 124 Peng (bib0465) 2015; 6 Kelly (bib0530) 2015; 427 Guo (bib0430) 2014; 15 Broadbent (bib0345) 2015; 16 Hansen (bib0410) 2011; 30 Szabo (bib0350) 2015; 16 Yang (bib0610) 2015 Lu (bib0340) 2015; 21 Li (bib0605) 2015; 25 Ashwal-Fluss (bib0360) 2014; 56 Lasda, Parker (bib0320) 2014; 20 Nigro (bib0385) 1991; 64 Lewis (bib0495) 2003; 100 Dolci (bib0560) 1997; 57 Zlotorynski (bib0500) 2015; 16 Schmucker (bib0510) 2000; 101 Cocquerelle (bib0390) 1992; 11 Boutz (bib0490) 2015; 29 Kramer (bib0375) 2015; 29 Barrett (bib0555) 2015; 4 Nam (bib0440) 1997; 17 Capel (bib0435) 1993; 73 Zhang (bib0505) 2013; 51 Hansen (bib0425) 2013; 495 Westholm (bib0595) 2014; 9 Thu (bib0520) 2014; 158 You (bib0575) 2015; 18 Memczak (bib0565) 2015; 10 Veno (bib0580) 2015; 16 Rybak-Wolf (bib0585) 2015; 58 Salzman (bib0355) 2013; 9 Jeck (bib0330) 2013; 19 Westholm (bib0365) 2014; 9 Salzman (bib0310) 2012; 7 Rodriguez-Trelles (bib0480) 2006; 40 Jeck, Sharpless (bib0315) 2014; 32 Alhasan (bib0600) 2015; 127 Wang (bib0335) 2014; 9 Lytton, Li (bib0450) 1999; 274 Capel (bib0535) 1998; 60 Bailleul (bib0400) 1996; 24 Memczak (bib0325) 2013; 495 Zaphiropoulos (bib0405) 1997 Salzman (bib0470) 2011; 9 Burd (bib0415) 2010; 6 Zhang (bib0570) 2014; 159 Ivanov (bib0540) 2015; 10 Treutlein (bib0515) 2014; 111 Lokody (bib0525) 2014; 15 Liang, Wilusz (bib0545) 2014; 28 Houseley (bib0445) 2006; 97 Starke (10.1016/j.tig.2016.03.002_bib0550) 2015; 10 Nam (10.1016/j.tig.2016.03.002_bib0440) 1997; 17 Treutlein (10.1016/j.tig.2016.03.002_bib0515) 2014; 111 Zhang (10.1016/j.tig.2016.03.002_bib0570) 2014; 159 Zaphiropoulos (10.1016/j.tig.2016.03.002_bib0405) 1997 Cocquerelle (10.1016/j.tig.2016.03.002_bib0390) 1992; 11 Koopman (10.1016/j.tig.2016.03.002_bib0420) 1990; 348 Lewis (10.1016/j.tig.2016.03.002_bib0495) 2003; 100 Alhasan (10.1016/j.tig.2016.03.002_bib0600) 2015; 127 Coca-Prados (10.1016/j.tig.2016.03.002_bib0380) 1979; 280 Burd (10.1016/j.tig.2016.03.002_bib0415) 2010; 6 Hansen (10.1016/j.tig.2016.03.002_bib0410) 2011; 30 Conn (10.1016/j.tig.2016.03.002_bib0370) 2015; 160 Zlotorynski (10.1016/j.tig.2016.03.002_bib0500) 2015; 16 Liang (10.1016/j.tig.2016.03.002_bib0545) 2014; 28 Salzman (10.1016/j.tig.2016.03.002_bib0310) 2012; 7 Lasda (10.1016/j.tig.2016.03.002_bib0320) 2014; 20 Veno (10.1016/j.tig.2016.03.002_bib0580) 2015; 16 Begemann (10.1016/j.tig.2016.03.002_bib0590) 1997; 124 Rodriguez-Trelles (10.1016/j.tig.2016.03.002_bib0480) 2006; 40 Schmucker (10.1016/j.tig.2016.03.002_bib0510) 2000; 101 Lokody (10.1016/j.tig.2016.03.002_bib0525) 2014; 15 Broadbent (10.1016/j.tig.2016.03.002_bib0345) 2015; 16 Lu (10.1016/j.tig.2016.03.002_bib0340) 2015; 21 Salzman (10.1016/j.tig.2016.03.002_bib0470) 2011; 9 Nigro (10.1016/j.tig.2016.03.002_bib0385) 1991; 64 Yang (10.1016/j.tig.2016.03.002_bib0610) 2015 Bailleul (10.1016/j.tig.2016.03.002_bib0400) 1996; 24 Li (10.1016/j.tig.2016.03.002_bib0605) 2015; 25 Szabo (10.1016/j.tig.2016.03.002_bib0350) 2015; 16 Kramer (10.1016/j.tig.2016.03.002_bib0375) 2015; 29 Ashwal-Fluss (10.1016/j.tig.2016.03.002_bib0360) 2014; 56 You (10.1016/j.tig.2016.03.002_bib0575) 2015; 18 Boutz (10.1016/j.tig.2016.03.002_bib0490) 2015; 29 Salzman (10.1016/j.tig.2016.03.002_bib0355) 2013; 9 Capel (10.1016/j.tig.2016.03.002_bib0535) 1998; 60 Kelly (10.1016/j.tig.2016.03.002_bib0530) 2015; 427 Thu (10.1016/j.tig.2016.03.002_bib0520) 2014; 158 Wang (10.1016/j.tig.2016.03.002_bib0335) 2014; 9 Westholm (10.1016/j.tig.2016.03.002_bib0365) 2014; 9 Dichmann (10.1016/j.tig.2016.03.002_bib0485) 2012; 26 Memczak (10.1016/j.tig.2016.03.002_bib0565) 2015; 10 Hooper (10.1016/j.tig.2016.03.002_bib0455) 2014; 8 Zhang (10.1016/j.tig.2016.03.002_bib0505) 2013; 51 Westholm (10.1016/j.tig.2016.03.002_bib0595) 2014; 9 Jeck (10.1016/j.tig.2016.03.002_bib0315) 2014; 32 Houseley (10.1016/j.tig.2016.03.002_bib0445) 2006; 97 Guo (10.1016/j.tig.2016.03.002_bib0430) 2014; 15 Barrett (10.1016/j.tig.2016.03.002_bib0555) 2015; 4 Memczak (10.1016/j.tig.2016.03.002_bib0325) 2013; 495 Lytton (10.1016/j.tig.2016.03.002_bib0450) 1999; 274 Saad (10.1016/j.tig.2016.03.002_bib0395) 1992; 1 Hansen (10.1016/j.tig.2016.03.002_bib0425) 2013; 495 Dolci (10.1016/j.tig.2016.03.002_bib0560) 1997; 57 Peng (10.1016/j.tig.2016.03.002_bib0465) 2015; 6 Rybak-Wolf (10.1016/j.tig.2016.03.002_bib0585) 2015; 58 Vincent (10.1016/j.tig.2016.03.002_bib0475) 2006; 281 Jeck (10.1016/j.tig.2016.03.002_bib0330) 2013; 19 Grabherr (10.1016/j.tig.2016.03.002_bib0460) 2011; 29 Ivanov (10.1016/j.tig.2016.03.002_bib0540) 2015; 10 Capel (10.1016/j.tig.2016.03.002_bib0435) 1993; 73 26464523 - RNA. 2015 Dec;21(12):2076-87 1303213 - Hum Mol Genet. 1992 Aug;1(5):345-6 21151960 - PLoS Genet. 2010 Dec 02;6(12):e1001233 7684656 - Cell. 1993 Jun 4;73(5):1019-30 10075718 - J Biol Chem. 1999 Mar 19;274(12):8153-60 17094737 - Annu Rev Genet. 2006;40:47-76 25070500 - Genome Biol. 2014 Jul 29;15(7):409 22319583 - PLoS One. 2012;7(2):e30733 25171406 - Cell. 2014 Aug 28;158(5):1045-59 26660425 - Blood. 2016 Mar 3;127(9):e1-e11 24039610 - PLoS Genet. 2013;9(9):e1003777 25544350 - Cell Rep. 2014 Dec 11;9(5):1966-80 25561496 - Genes Dev. 2015 Jan 1;29(1):63-80 23249747 - RNA. 2013 Feb;19(2):141-57 25404635 - RNA. 2014 Dec;20(12):1829-42 21964070 - EMBO J. 2011 Sep 30;30(21):4414-22 26138677 - Cell Res. 2015 Aug;25(8):981-4 16714427 - J Hered. 2006 May-Jun;97(3):253-60 21572440 - Nat Biotechnol. 2011 May 15;29(7):644-52 16893880 - J Biol Chem. 2006 Oct 6;281(40):29769-75 25558066 - Cell Rep. 2015 Jan 13;10(2):170-7 25543144 - Cell Rep. 2015 Jan 6;10(1):103-11 9369180 - Biol Reprod. 1997 Nov;57(5):1128-35 1339341 - EMBO J. 1992 Mar;11(3):1095-8 26450910 - Genes Dev. 2015 Oct 15;29(20):2168-82 25242144 - Mol Cell. 2014 Oct 2;56(1):55-66 25728652 - J Mol Biol. 2015 Jul 31;427(15):2414-7 24639501 - Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):E1291-9 9558474 - Annu Rev Physiol. 1998;60:497-523 26485708 - PLoS One. 2015 Oct 20;10(10):e0141214 25714049 - Nat Neurosci. 2015 Apr;18(4):603-10 24811520 - Nat Biotechnol. 2014 May;32(5):453-61 9001235 - Mol Cell Biol. 1997 Feb;17(2):809-18 24609083 - PLoS One. 2014 Mar 07;9(6):e90859 26541409 - Genome Biol. 2015 Nov 05;16:245 1991322 - Cell. 1991 Feb 8;64(3):607-13 25714680 - Nat Rev Mol Cell Biol. 2015 Apr;16(4):206 9334280 - Development. 1997 Nov;124(21):4321-31 25281217 - Genes Dev. 2014 Oct 15;28(20):2233-47 22713872 - Genes Dev. 2012 Jun 15;26(12):1351-63 460409 - Nature. 1979 Jul 26;280(5720):339-40 23446348 - Nature. 2013 Mar 21;495(7441):333-8 26076956 - Genome Biol. 2015 Jun 16;16:126 26657152 - Oncogene. 2016 Jul 28;35(30):3919-31 25921068 - Mol Cell. 2015 Jun 4;58(5):870-85 24447644 - Hum Genomics. 2014 Jan 21;8:3 25242744 - Cell. 2014 Sep 25;159(1):134-47 10892653 - Cell. 2000 Jun 9;101(6):671-84 9154796 - Mol Cell Biol. 1997 Jun;17(6):2985-93 26057830 - Elife. 2015 Jun 09;4:e07540 26070627 - BMC Genomics. 2015 Jun 13;16:454 8604331 - Nucleic Acids Res. 1996 Mar 15;24(6):1015-9 24035497 - Mol Cell. 2013 Sep 26;51(6):792-806 25324005 - Nat Rev Genet. 2014 Nov;15(11):706 12502788 - Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):189-92 2247150 - Nature. 1990 Nov 29;348(6300):450-2 23446346 - Nature. 2013 Mar 21;495(7441):384-8 25768908 - Cell. 2015 Mar 12;160(6):1125-34 26000048 - J Cancer. 2015 May 01;6(6):555-67 21949640 - PLoS Biol. 2011 Sep;9(9):e1001156
References_xml	– volume: 159 start-page: 134 year: 2014 end-page: 147 ident: bib0570 article-title: Complementary sequence-mediated exon circularization publication-title: Cell – volume: 19 start-page: 141 year: 2013 end-page: 157 ident: bib0330 article-title: Circular RNAs are abundant, conserved, and associated with ALU repeats publication-title: RNA – volume: 6 start-page: 555 year: 2015 end-page: 567 ident: bib0465 article-title: Hypothesis: artifacts, including spurious chimeric RNAs with a short homologous sequence, caused by consecutive reverse transcriptions and endogenous random primers publication-title: J. Cancer – volume: 25 start-page: 981 year: 2015 end-page: 984 ident: bib0605 article-title: Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis publication-title: Cell Res. – volume: 57 start-page: 1128 year: 1997 end-page: 1135 ident: bib0560 article-title: Identification of a promoter region generating Sry circular transcripts both in germ cells from male adult mice and in male mouse embryonal gonads publication-title: Biol. Reprod. – volume: 73 start-page: 1019 year: 1993 end-page: 1030 ident: bib0435 article-title: Circular transcripts of the testis-determining gene Sry in adult mouse testis publication-title: Cell – volume: 20 start-page: 1829 year: 2014 end-page: 1842 ident: bib0320 article-title: Circular RNAs: diversity of form and function publication-title: RNA – volume: 427 start-page: 2414 year: 2015 end-page: 2417 ident: bib0530 article-title: Exon skipping is correlated with exon circularization publication-title: J. Mol. Biol. – volume: 101 start-page: 671 year: 2000 end-page: 684 ident: bib0510 article-title: Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity publication-title: Cell – volume: 21 start-page: 2076 year: 2015 end-page: 2087 ident: bib0340 article-title: Transcriptome-wide investigation of circular RNAs in rice publication-title: RNA – volume: 24 start-page: 1015 year: 1996 end-page: 1019 ident: bib0400 article-title: During in vivo maturation of eukaryotic nuclear mRNA, splicing yields excised exon circles publication-title: Nucleic Acids Res. – volume: 10 start-page: 170 year: 2015 end-page: 177 ident: bib0540 article-title: Analysis of intron sequences reveals hallmarks of circular RNA biogenesis in animals publication-title: Cell Rep. – volume: 26 start-page: 1351 year: 2012 end-page: 1363 ident: bib0485 article-title: fus/TLS orchestrates splicing of developmental regulators during gastrulation publication-title: Genes Dev. – volume: 280 start-page: 339 year: 1979 end-page: 340 ident: bib0380 article-title: Electron microscopic evidence for the circular form of RNA in the cytoplasm of eukaryotic cells publication-title: Nature – volume: 29 start-page: 644 year: 2011 end-page: 652 ident: bib0460 article-title: Full-length transcriptome assembly from RNA-Seq data without a reference genome publication-title: Nat. Biotechnol. – volume: 160 start-page: 1125 year: 2015 end-page: 1134 ident: bib0370 article-title: The RNA binding protein quaking regulates formation of circRNAs publication-title: Cell – volume: 6 start-page: e1001233 year: 2010 ident: bib0415 article-title: Expression of linear and novel circular forms of an INK4/ARF-associated non–coding RNA correlates with atherosclerosis risk publication-title: PLoS Genet. – volume: 111 start-page: E1291 year: 2014 end-page: E1299 ident: bib0515 article-title: Cartography of neurexin alternative splicing mapped by single-molecule long-read mRNA sequencing publication-title: Proc. Natl. Acad. Sci. U.S.A. – volume: 274 start-page: 8153 year: 1999 end-page: 8160 ident: bib0450 article-title: A circularized sodium-calcium exchanger exon 2 transcript publication-title: J. Biol. Chem. – volume: 58 start-page: 870 year: 2015 end-page: 885 ident: bib0585 article-title: Circular RNAs in the mammalian brain are highly abundant, conserved, and dynamically expressed publication-title: Mol. Cell – volume: 97 start-page: 253 year: 2006 end-page: 260 ident: bib0445 article-title: Noncanonical RNAs from transcripts of the publication-title: J. Heredity – volume: 495 start-page: 333 year: 2013 end-page: 338 ident: bib0325 article-title: Circular RNAs are a large class of animal RNAs with regulatory potency publication-title: Nature – volume: 40 start-page: 47 year: 2006 end-page: 76 ident: bib0480 article-title: Origins and evolution of spliceosomal introns publication-title: Annu. Rev. Genet. – volume: 158 start-page: 1045 year: 2014 end-page: 1059 ident: bib0520 article-title: Single-cell identity generated by combinatorial homophilic interactions between alpha, beta, and gamma protocadherins publication-title: Cell – volume: 10 start-page: 103 year: 2015 end-page: 111 ident: bib0550 article-title: Exon circularization requires canonical splice signals publication-title: Cell Rep. – volume: 28 start-page: 2233 year: 2014 end-page: 2247 ident: bib0545 article-title: Short intronic repeat sequences facilitate circular RNA production publication-title: Genes Dev. – volume: 64 start-page: 607 year: 1991 end-page: 613 ident: bib0385 article-title: Scrambled exons publication-title: Cell – volume: 495 start-page: 384 year: 2013 end-page: 388 ident: bib0425 article-title: Natural RNA circles function as efficient microRNA sponges publication-title: Nature – volume: 11 start-page: 1095 year: 1992 end-page: 1098 ident: bib0390 article-title: Splicing with inverted order of exons occurs proximal to large introns publication-title: EMBO J. – volume: 8 start-page: 3 year: 2014 ident: bib0455 article-title: A survey of software for genome-wide discovery of differential splicing in RNA-Seq data publication-title: Hum. Genomics – volume: 9 start-page: 1966 year: 2014 end-page: 1980 ident: bib0595 article-title: Genome-wide analysis of drosophila circular RNAs reveals their structural and sequence properties and age-dependent neural accumulation publication-title: Cell Rep. – volume: 56 start-page: 55 year: 2014 end-page: 66 ident: bib0360 article-title: circRNA biogenesis competes with pre-mRNA splicing publication-title: Mol. Cell – volume: 9 start-page: e1003777 year: 2013 ident: bib0355 article-title: Cell-type specific regulation of circular RNA expression publication-title: PLoS Genet. – start-page: 2985 year: 1997 end-page: 2993 ident: bib0405 article-title: Exon skipping and circular RNA formation in transcripts of the human cytochrome P-450 2C18 gene in epidermis and of the rat androgen binding protein gene in testis publication-title: Mol. Cell. Biol. – volume: 29 start-page: 63 year: 2015 end-page: 80 ident: bib0490 article-title: Detained introns are a novel, widespread class of post-transcriptionally spliced introns publication-title: Genes Dev. – volume: 127 start-page: e1 year: 2015 end-page: e11 ident: bib0600 article-title: Circular RNA enrichment in platelets is a signature of transcriptome degradation publication-title: Blood – volume: 4 start-page: e07540 year: 2015 ident: bib0555 article-title: Circular RNA biogenesis can proceed through an exon-containing lariat precursor publication-title: Elife – volume: 100 start-page: 189 year: 2003 end-page: 192 ident: bib0495 article-title: Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans publication-title: Proc. Natl. Acad. Sci. U.S.A. – year: 2015 ident: bib0610 article-title: Foxo3 activity promoted by non-coding effects of circular RNA and Foxo3 pseudogene in the inhibition of tumor growth and angiogenesis publication-title: Oncogene – volume: 1 start-page: 345 year: 1992 end-page: 346 ident: bib0395 article-title: A 3′ consensus splice mutation in the human dystrophin gene detected by a screening for intra-exonic deletions publication-title: Hum. Mol. Genet. – volume: 10 start-page: e0141214 year: 2015 ident: bib0565 article-title: Identification and characterization of circular RNAs as a new class of putative biomarkers in human blood publication-title: PLoS ONE – volume: 281 start-page: 29769 year: 2006 end-page: 29775 ident: bib0475 article-title: Substrate recognition and catalysis by the exoribonuclease RNase R publication-title: J. Biol. Chem. – volume: 7 start-page: e30733 year: 2012 ident: bib0310 article-title: Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types publication-title: PLoS ONE – volume: 9 start-page: e1001156 year: 2011 ident: bib0470 article-title: ESRRA-C11orf20 is a recurrent gene fusion in serous ovarian carcinoma publication-title: PLoS Biol. – volume: 60 start-page: 497 year: 1998 end-page: 523 ident: bib0535 article-title: Sex in the 90s: SRY and the switch to the male pathway publication-title: Annu. Rev. Physiol. – volume: 16 start-page: 206 year: 2015 ident: bib0500 article-title: Non-coding RNA: circular RNAs promote transcription publication-title: Nat. Rev. Mol. Cell Biol. – volume: 124 start-page: 4321 year: 1997 end-page: 4331 ident: bib0590 article-title: muscleblind, a gene required for photoreceptor differentiation in Drosophila, encodes novel nuclear Cys3His-type zinc-finger-containing proteins publication-title: Development – volume: 16 start-page: 245 year: 2015 ident: bib0580 article-title: Spatio-temporal regulation of circular RNA expression during porcine embryonic brain development publication-title: Genome Biol. – volume: 30 start-page: 4414 year: 2011 end-page: 4422 ident: bib0410 article-title: miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA publication-title: EMBO J. – volume: 15 start-page: 409 year: 2014 ident: bib0430 article-title: Expanded identification and characterization of mammalian circular RNAs publication-title: Genome Biol. – volume: 29 start-page: 2168 year: 2015 end-page: 2182 ident: bib0375 article-title: Combinatorial control of publication-title: Genes Dev. – volume: 17 start-page: 809 year: 1997 end-page: 818 ident: bib0440 article-title: Severe growth defect in a publication-title: Mol. Cell. Biol. – volume: 9 start-page: e90859 year: 2014 ident: bib0335 article-title: Circular RNA is expressed across the eukaryotic tree of life publication-title: PLoS ONE – volume: 16 start-page: 454 year: 2015 ident: bib0345 article-title: Strand-specific RNA sequencing in publication-title: BMC Genomics – volume: 51 start-page: 792 year: 2013 end-page: 806 ident: bib0505 article-title: Circular intronic long noncoding RNAs publication-title: Mol. Cell – volume: 18 start-page: 603 year: 2015 end-page: 610 ident: bib0575 article-title: Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity publication-title: Nat. Neurosci. – volume: 15 start-page: 706 year: 2014 ident: bib0525 article-title: Alternative splicing: characterizing cell fate publication-title: Nat. Rev. Genet. – volume: 16 start-page: 126 year: 2015 ident: bib0350 article-title: Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development publication-title: Genome Biol. – volume: 348 start-page: 450 year: 1990 end-page: 452 ident: bib0420 article-title: Expression of a candidate sex-determining gene during mouse testis differentiation publication-title: Nature – volume: 32 start-page: 453 year: 2014 end-page: 461 ident: bib0315 article-title: Detecting and characterizing circular RNAs publication-title: Nat. Biotechnol. – volume: 9 start-page: 1966 year: 2014 end-page: 1980 ident: bib0365 article-title: Genome-wide analysis of publication-title: Cell Rep. – volume: 21 start-page: 2076 year: 2015 ident: 10.1016/j.tig.2016.03.002_bib0340 article-title: Transcriptome-wide investigation of circular RNAs in rice publication-title: RNA doi: 10.1261/rna.052282.115 – volume: 158 start-page: 1045 year: 2014 ident: 10.1016/j.tig.2016.03.002_bib0520 article-title: Single-cell identity generated by combinatorial homophilic interactions between alpha, beta, and gamma protocadherins publication-title: Cell doi: 10.1016/j.cell.2014.07.012 – volume: 16 start-page: 454 year: 2015 ident: 10.1016/j.tig.2016.03.002_bib0345 article-title: Strand-specific RNA sequencing in Plasmodium falciparum malaria identifies developmentally regulated long non-coding RNA and circular RNA publication-title: BMC Genomics doi: 10.1186/s12864-015-1603-4 – volume: 20 start-page: 1829 year: 2014 ident: 10.1016/j.tig.2016.03.002_bib0320 article-title: Circular RNAs: diversity of form and function publication-title: RNA doi: 10.1261/rna.047126.114 – volume: 29 start-page: 2168 year: 2015 ident: 10.1016/j.tig.2016.03.002_bib0375 article-title: Combinatorial control of Drosophila circular RNA expression by intronic repeats, hnRNPs, and SR proteins publication-title: Genes Dev. doi: 10.1101/gad.270421.115 – volume: 40 start-page: 47 year: 2006 ident: 10.1016/j.tig.2016.03.002_bib0480 article-title: Origins and evolution of spliceosomal introns publication-title: Annu. Rev. Genet. doi: 10.1146/annurev.genet.40.110405.090625 – volume: 73 start-page: 1019 year: 1993 ident: 10.1016/j.tig.2016.03.002_bib0435 article-title: Circular transcripts of the testis-determining gene Sry in adult mouse testis publication-title: Cell doi: 10.1016/0092-8674(93)90279-Y – volume: 101 start-page: 671 year: 2000 ident: 10.1016/j.tig.2016.03.002_bib0510 article-title: Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity publication-title: Cell doi: 10.1016/S0092-8674(00)80878-8 – volume: 274 start-page: 8153 year: 1999 ident: 10.1016/j.tig.2016.03.002_bib0450 article-title: A circularized sodium-calcium exchanger exon 2 transcript publication-title: J. Biol. Chem. doi: 10.1074/jbc.274.12.8153 – volume: 495 start-page: 384 year: 2013 ident: 10.1016/j.tig.2016.03.002_bib0425 article-title: Natural RNA circles function as efficient microRNA sponges publication-title: Nature doi: 10.1038/nature11993 – volume: 6 start-page: 555 year: 2015 ident: 10.1016/j.tig.2016.03.002_bib0465 article-title: Hypothesis: artifacts, including spurious chimeric RNAs with a short homologous sequence, caused by consecutive reverse transcriptions and endogenous random primers publication-title: J. Cancer doi: 10.7150/jca.11997 – volume: 9 start-page: e90859 year: 2014 ident: 10.1016/j.tig.2016.03.002_bib0335 article-title: Circular RNA is expressed across the eukaryotic tree of life publication-title: PLoS ONE doi: 10.1371/journal.pone.0090859 – volume: 10 start-page: 170 year: 2015 ident: 10.1016/j.tig.2016.03.002_bib0540 article-title: Analysis of intron sequences reveals hallmarks of circular RNA biogenesis in animals publication-title: Cell Rep. doi: 10.1016/j.celrep.2014.12.019 – volume: 127 start-page: e1 year: 2015 ident: 10.1016/j.tig.2016.03.002_bib0600 article-title: Circular RNA enrichment in platelets is a signature of transcriptome degradation publication-title: Blood doi: 10.1182/blood-2015-06-649434 – volume: 16 start-page: 126 year: 2015 ident: 10.1016/j.tig.2016.03.002_bib0350 article-title: Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development publication-title: Genome Biol. doi: 10.1186/s13059-015-0690-5 – volume: 56 start-page: 55 year: 2014 ident: 10.1016/j.tig.2016.03.002_bib0360 article-title: circRNA biogenesis competes with pre-mRNA splicing publication-title: Mol. Cell doi: 10.1016/j.molcel.2014.08.019 – volume: 11 start-page: 1095 year: 1992 ident: 10.1016/j.tig.2016.03.002_bib0390 article-title: Splicing with inverted order of exons occurs proximal to large introns publication-title: EMBO J. doi: 10.1002/j.1460-2075.1992.tb05148.x – volume: 495 start-page: 333 year: 2013 ident: 10.1016/j.tig.2016.03.002_bib0325 article-title: Circular RNAs are a large class of animal RNAs with regulatory potency publication-title: Nature doi: 10.1038/nature11928 – volume: 24 start-page: 1015 year: 1996 ident: 10.1016/j.tig.2016.03.002_bib0400 article-title: During in vivo maturation of eukaryotic nuclear mRNA, splicing yields excised exon circles publication-title: Nucleic Acids Res. doi: 10.1093/nar/24.6.1015 – volume: 159 start-page: 134 year: 2014 ident: 10.1016/j.tig.2016.03.002_bib0570 article-title: Complementary sequence-mediated exon circularization publication-title: Cell doi: 10.1016/j.cell.2014.09.001 – volume: 15 start-page: 706 year: 2014 ident: 10.1016/j.tig.2016.03.002_bib0525 article-title: Alternative splicing: characterizing cell fate publication-title: Nat. Rev. Genet. doi: 10.1038/nrg3847 – volume: 427 start-page: 2414 year: 2015 ident: 10.1016/j.tig.2016.03.002_bib0530 article-title: Exon skipping is correlated with exon circularization publication-title: J. Mol. Biol. doi: 10.1016/j.jmb.2015.02.018 – volume: 18 start-page: 603 year: 2015 ident: 10.1016/j.tig.2016.03.002_bib0575 article-title: Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity publication-title: Nat. Neurosci. doi: 10.1038/nn.3975 – volume: 64 start-page: 607 year: 1991 ident: 10.1016/j.tig.2016.03.002_bib0385 article-title: Scrambled exons publication-title: Cell doi: 10.1016/0092-8674(91)90244-S – volume: 7 start-page: e30733 year: 2012 ident: 10.1016/j.tig.2016.03.002_bib0310 article-title: Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types publication-title: PLoS ONE doi: 10.1371/journal.pone.0030733 – volume: 29 start-page: 63 year: 2015 ident: 10.1016/j.tig.2016.03.002_bib0490 article-title: Detained introns are a novel, widespread class of post-transcriptionally spliced introns publication-title: Genes Dev. doi: 10.1101/gad.247361.114 – volume: 160 start-page: 1125 year: 2015 ident: 10.1016/j.tig.2016.03.002_bib0370 article-title: The RNA binding protein quaking regulates formation of circRNAs publication-title: Cell doi: 10.1016/j.cell.2015.02.014 – volume: 15 start-page: 409 year: 2014 ident: 10.1016/j.tig.2016.03.002_bib0430 article-title: Expanded identification and characterization of mammalian circular RNAs publication-title: Genome Biol. doi: 10.1186/s13059-014-0409-z – volume: 124 start-page: 4321 year: 1997 ident: 10.1016/j.tig.2016.03.002_bib0590 article-title: muscleblind, a gene required for photoreceptor differentiation in Drosophila, encodes novel nuclear Cys3His-type zinc-finger-containing proteins publication-title: Development doi: 10.1242/dev.124.21.4321 – volume: 280 start-page: 339 year: 1979 ident: 10.1016/j.tig.2016.03.002_bib0380 article-title: Electron microscopic evidence for the circular form of RNA in the cytoplasm of eukaryotic cells publication-title: Nature doi: 10.1038/280339a0 – volume: 10 start-page: e0141214 year: 2015 ident: 10.1016/j.tig.2016.03.002_bib0565 article-title: Identification and characterization of circular RNAs as a new class of putative biomarkers in human blood publication-title: PLoS ONE doi: 10.1371/journal.pone.0141214 – volume: 51 start-page: 792 year: 2013 ident: 10.1016/j.tig.2016.03.002_bib0505 article-title: Circular intronic long noncoding RNAs publication-title: Mol. Cell doi: 10.1016/j.molcel.2013.08.017 – volume: 8 start-page: 3 year: 2014 ident: 10.1016/j.tig.2016.03.002_bib0455 article-title: A survey of software for genome-wide discovery of differential splicing in RNA-Seq data publication-title: Hum. Genomics doi: 10.1186/1479-7364-8-3 – volume: 16 start-page: 206 year: 2015 ident: 10.1016/j.tig.2016.03.002_bib0500 article-title: Non-coding RNA: circular RNAs promote transcription publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm3967 – volume: 281 start-page: 29769 year: 2006 ident: 10.1016/j.tig.2016.03.002_bib0475 article-title: Substrate recognition and catalysis by the exoribonuclease RNase R publication-title: J. Biol. Chem. doi: 10.1074/jbc.M606744200 – volume: 10 start-page: 103 year: 2015 ident: 10.1016/j.tig.2016.03.002_bib0550 article-title: Exon circularization requires canonical splice signals publication-title: Cell Rep. doi: 10.1016/j.celrep.2014.12.002 – volume: 25 start-page: 981 year: 2015 ident: 10.1016/j.tig.2016.03.002_bib0605 article-title: Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis publication-title: Cell Res. doi: 10.1038/cr.2015.82 – volume: 30 start-page: 4414 year: 2011 ident: 10.1016/j.tig.2016.03.002_bib0410 article-title: miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA publication-title: EMBO J. doi: 10.1038/emboj.2011.359 – volume: 29 start-page: 644 year: 2011 ident: 10.1016/j.tig.2016.03.002_bib0460 article-title: Full-length transcriptome assembly from RNA-Seq data without a reference genome publication-title: Nat. Biotechnol. doi: 10.1038/nbt.1883 – volume: 16 start-page: 245 year: 2015 ident: 10.1016/j.tig.2016.03.002_bib0580 article-title: Spatio-temporal regulation of circular RNA expression during porcine embryonic brain development publication-title: Genome Biol. doi: 10.1186/s13059-015-0801-3 – volume: 9 start-page: e1003777 year: 2013 ident: 10.1016/j.tig.2016.03.002_bib0355 article-title: Cell-type specific regulation of circular RNA expression publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1003777 – volume: 58 start-page: 870 year: 2015 ident: 10.1016/j.tig.2016.03.002_bib0585 article-title: Circular RNAs in the mammalian brain are highly abundant, conserved, and dynamically expressed publication-title: Mol. Cell doi: 10.1016/j.molcel.2015.03.027 – volume: 111 start-page: E1291 year: 2014 ident: 10.1016/j.tig.2016.03.002_bib0515 article-title: Cartography of neurexin alternative splicing mapped by single-molecule long-read mRNA sequencing publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.1403244111 – volume: 32 start-page: 453 year: 2014 ident: 10.1016/j.tig.2016.03.002_bib0315 article-title: Detecting and characterizing circular RNAs publication-title: Nat. Biotechnol. doi: 10.1038/nbt.2890 – volume: 4 start-page: e07540 year: 2015 ident: 10.1016/j.tig.2016.03.002_bib0555 article-title: Circular RNA biogenesis can proceed through an exon-containing lariat precursor publication-title: Elife doi: 10.7554/eLife.07540 – volume: 26 start-page: 1351 year: 2012 ident: 10.1016/j.tig.2016.03.002_bib0485 article-title: fus/TLS orchestrates splicing of developmental regulators during gastrulation publication-title: Genes Dev. doi: 10.1101/gad.187278.112 – volume: 9 start-page: 1966 year: 2014 ident: 10.1016/j.tig.2016.03.002_bib0595 article-title: Genome-wide analysis of drosophila circular RNAs reveals their structural and sequence properties and age-dependent neural accumulation publication-title: Cell Rep. doi: 10.1016/j.celrep.2014.10.062 – volume: 6 start-page: e1001233 year: 2010 ident: 10.1016/j.tig.2016.03.002_bib0415 article-title: Expression of linear and novel circular forms of an INK4/ARF-associated non–coding RNA correlates with atherosclerosis risk publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1001233 – start-page: 2985 year: 1997 ident: 10.1016/j.tig.2016.03.002_bib0405 article-title: Exon skipping and circular RNA formation in transcripts of the human cytochrome P-450 2C18 gene in epidermis and of the rat androgen binding protein gene in testis publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.17.6.2985 – volume: 60 start-page: 497 year: 1998 ident: 10.1016/j.tig.2016.03.002_bib0535 article-title: Sex in the 90s: SRY and the switch to the male pathway publication-title: Annu. Rev. Physiol. doi: 10.1146/annurev.physiol.60.1.497 – volume: 28 start-page: 2233 year: 2014 ident: 10.1016/j.tig.2016.03.002_bib0545 article-title: Short intronic repeat sequences facilitate circular RNA production publication-title: Genes Dev. doi: 10.1101/gad.251926.114 – volume: 9 start-page: e1001156 year: 2011 ident: 10.1016/j.tig.2016.03.002_bib0470 article-title: ESRRA-C11orf20 is a recurrent gene fusion in serous ovarian carcinoma publication-title: PLoS Biol. doi: 10.1371/journal.pbio.1001156 – volume: 57 start-page: 1128 year: 1997 ident: 10.1016/j.tig.2016.03.002_bib0560 article-title: Identification of a promoter region generating Sry circular transcripts both in germ cells from male adult mice and in male mouse embryonal gonads publication-title: Biol. Reprod. doi: 10.1095/biolreprod57.5.1128 – volume: 9 start-page: 1966 year: 2014 ident: 10.1016/j.tig.2016.03.002_bib0365 article-title: Genome-wide analysis of Drosophila circular RNAs reveals their structural and sequence properties and age-dependent neural accumulation publication-title: Cell Rep. doi: 10.1016/j.celrep.2014.10.062 – year: 2015 ident: 10.1016/j.tig.2016.03.002_bib0610 article-title: Foxo3 activity promoted by non-coding effects of circular RNA and Foxo3 pseudogene in the inhibition of tumor growth and angiogenesis publication-title: Oncogene – volume: 348 start-page: 450 year: 1990 ident: 10.1016/j.tig.2016.03.002_bib0420 article-title: Expression of a candidate sex-determining gene during mouse testis differentiation publication-title: Nature doi: 10.1038/348450a0 – volume: 17 start-page: 809 year: 1997 ident: 10.1016/j.tig.2016.03.002_bib0440 article-title: Severe growth defect in a Schizosaccharomyces pombe mutant defective in intron lariat degradation publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.17.2.809 – volume: 97 start-page: 253 year: 2006 ident: 10.1016/j.tig.2016.03.002_bib0445 article-title: Noncanonical RNAs from transcripts of the Drosophila muscleblind gene publication-title: J. Heredity doi: 10.1093/jhered/esj037 – volume: 19 start-page: 141 year: 2013 ident: 10.1016/j.tig.2016.03.002_bib0330 article-title: Circular RNAs are abundant, conserved, and associated with ALU repeats publication-title: RNA doi: 10.1261/rna.035667.112 – volume: 1 start-page: 345 year: 1992 ident: 10.1016/j.tig.2016.03.002_bib0395 article-title: A 3′ consensus splice mutation in the human dystrophin gene detected by a screening for intra-exonic deletions publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/1.5.345 – volume: 100 start-page: 189 year: 2003 ident: 10.1016/j.tig.2016.03.002_bib0495 article-title: Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.0136770100 – reference: 9154796 - Mol Cell Biol. 1997 Jun;17(6):2985-93 – reference: 21151960 - PLoS Genet. 2010 Dec 02;6(12):e1001233 – reference: 25543144 - Cell Rep. 2015 Jan 6;10(1):103-11 – reference: 12502788 - Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):189-92 – reference: 26485708 - PLoS One. 2015 Oct 20;10(10):e0141214 – reference: 21964070 - EMBO J. 2011 Sep 30;30(21):4414-22 – reference: 460409 - Nature. 1979 Jul 26;280(5720):339-40 – reference: 26138677 - Cell Res. 2015 Aug;25(8):981-4 – reference: 24039610 - PLoS Genet. 2013;9(9):e1003777 – reference: 8604331 - Nucleic Acids Res. 1996 Mar 15;24(6):1015-9 – reference: 26541409 - Genome Biol. 2015 Nov 05;16:245 – reference: 9001235 - Mol Cell Biol. 1997 Feb;17(2):809-18 – reference: 25242744 - Cell. 2014 Sep 25;159(1):134-47 – reference: 1303213 - Hum Mol Genet. 1992 Aug;1(5):345-6 – reference: 10892653 - Cell. 2000 Jun 9;101(6):671-84 – reference: 26657152 - Oncogene. 2016 Jul 28;35(30):3919-31 – reference: 26464523 - RNA. 2015 Dec;21(12):2076-87 – reference: 25728652 - J Mol Biol. 2015 Jul 31;427(15):2414-7 – reference: 26000048 - J Cancer. 2015 May 01;6(6):555-67 – reference: 25561496 - Genes Dev. 2015 Jan 1;29(1):63-80 – reference: 23446348 - Nature. 2013 Mar 21;495(7441):333-8 – reference: 21572440 - Nat Biotechnol. 2011 May 15;29(7):644-52 – reference: 25714049 - Nat Neurosci. 2015 Apr;18(4):603-10 – reference: 26057830 - Elife. 2015 Jun 09;4:e07540 – reference: 25544350 - Cell Rep. 2014 Dec 11;9(5):1966-80 – reference: 24609083 - PLoS One. 2014 Mar 07;9(6):e90859 – reference: 23446346 - Nature. 2013 Mar 21;495(7441):384-8 – reference: 24811520 - Nat Biotechnol. 2014 May;32(5):453-61 – reference: 17094737 - Annu Rev Genet. 2006;40:47-76 – reference: 25921068 - Mol Cell. 2015 Jun 4;58(5):870-85 – reference: 25404635 - RNA. 2014 Dec;20(12):1829-42 – reference: 24639501 - Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):E1291-9 – reference: 10075718 - J Biol Chem. 1999 Mar 19;274(12):8153-60 – reference: 26450910 - Genes Dev. 2015 Oct 15;29(20):2168-82 – reference: 9334280 - Development. 1997 Nov;124(21):4321-31 – reference: 1339341 - EMBO J. 1992 Mar;11(3):1095-8 – reference: 25768908 - Cell. 2015 Mar 12;160(6):1125-34 – reference: 23249747 - RNA. 2013 Feb;19(2):141-57 – reference: 25281217 - Genes Dev. 2014 Oct 15;28(20):2233-47 – reference: 16714427 - J Hered. 2006 May-Jun;97(3):253-60 – reference: 25714680 - Nat Rev Mol Cell Biol. 2015 Apr;16(4):206 – reference: 25070500 - Genome Biol. 2014 Jul 29;15(7):409 – reference: 26070627 - BMC Genomics. 2015 Jun 13;16:454 – reference: 25171406 - Cell. 2014 Aug 28;158(5):1045-59 – reference: 25324005 - Nat Rev Genet. 2014 Nov;15(11):706 – reference: 9369180 - Biol Reprod. 1997 Nov;57(5):1128-35 – reference: 16893880 - J Biol Chem. 2006 Oct 6;281(40):29769-75 – reference: 26660425 - Blood. 2016 Mar 3;127(9):e1-e11 – reference: 9558474 - Annu Rev Physiol. 1998;60:497-523 – reference: 22319583 - PLoS One. 2012;7(2):e30733 – reference: 1991322 - Cell. 1991 Feb 8;64(3):607-13 – reference: 24447644 - Hum Genomics. 2014 Jan 21;8:3 – reference: 26076956 - Genome Biol. 2015 Jun 16;16:126 – reference: 21949640 - PLoS Biol. 2011 Sep;9(9):e1001156 – reference: 25242144 - Mol Cell. 2014 Oct 2;56(1):55-66 – reference: 25558066 - Cell Rep. 2015 Jan 13;10(2):170-7 – reference: 24035497 - Mol Cell. 2013 Sep 26;51(6):792-806 – reference: 2247150 - Nature. 1990 Nov 29;348(6300):450-2 – reference: 22713872 - Genes Dev. 2012 Jun 15;26(12):1351-63 – reference: 7684656 - Cell. 1993 Jun 4;73(5):1019-30
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Snippet	In 2012, a new feature of eukaryotic gene expression emerged: ubiquitous expression of circular RNA (circRNA) from genes traditionally thought to express...
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SubjectTerms	circRNA circular RNA Gene Expression Regulation Humans Medical Education RNA RNA - biosynthesis RNA - genetics RNA splicing RNA Splicing - genetics
Title	Circular RNA Expression: Its Potential Regulation and Function
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