GSTM1 and GSTT1 Polymorphisms and the Risk of Prostate Cancer in a Caribbean Population of African Descent

• Published in: Urology Vol. 69; no. 6; pp. 1165 - 1169
• Main Authors: Mallick, Stéphane, Romana, Marc, Blanchet, Pascal, Multigner, Luc
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.06.2007; Elsevier BV; Elsevier Science; Elsevier
• Subjects: [SDV.CAN]Life Sciences [q-bio]/Cancer; African Americans; Aged; Biological and medical sciences; Black or African American; Cancer; Caribbean Region; Caribbean Region - epidemiology; Caribbean Region - ethnology; Case-Control Studies; Glutathione Transferase; Glutathione Transferase - genetics; Gynecology. Andrology. Obstetrics; Humans; Life Sciences; Male; Male genital diseases; Medical sciences; MESH: African Americans; MESH: Aged; MESH: Caribbean Region; MESH: Case-Control Studies; MESH: Glutathione Transferase; MESH: Humans; MESH: Male; MESH: Middle Aged; MESH: Polymerase Chain Reaction; MESH: Polymorphism, Genetic; MESH: Prostatic Neoplasms; MESH: Risk Factors; Middle Aged; Nephrology. Urinary tract diseases; Polymerase Chain Reaction; Polymorphism, Genetic; Prostatic Neoplasms; Prostatic Neoplasms - epidemiology; Prostatic Neoplasms - genetics; Risk Factors; Tumors; Tumors of the urinary system; Urinary tract. Prostate gland; Urology; Caribbean Region; Human; Nephrology; Urinary system disease; Genetic variability; Prostate disease; Enzyme; Isozyme; Transferases; Genotype; Malignant tumor; Epidemiology; Urology; African; Glutathione transferase; Risk factor; Population; Male genital diseases; Prostate cancer; Polymorphism
• ISSN: 0090-4295; 1527-9995; 1527-9995
• DOI: 10.1016/j.urology.2007.02.039

To investigate whether the glutathione S-transferase polymorphisms GSTM1 and/or GSTT1 contribute to prostate cancer risk in a Caribbean population of African descent in Guadeloupe. We performed a hospital-based case-control study with 134 prostate cancer patients and 134 cancer-free, age-matched control subjects. Epidemiologic data were collected using a standard questionnaire. Logistic regression was used to estimate odds ratios (ORs) and compute confidence intervals (CIs). Genotypes were determined by multiplex polymerase chain reaction. The frequency of the GSTM1-positive genotype was 81% in patients and 73% in control subjects, with an adjusted OR of 1.4 (95% CI 0.7 to 2.5). The frequency of the GSTT1-positive genotype was 78% in patients and 63% in control subjects, with an adjusted OR of 2.6 (95% CI 1.4 to 4.9). A functional GSTT1 polymorphism may be associated with prostate cancer susceptibility in a Caribbean population of African descent.