The impact of ferritin fluctuations on stable hemoglobin levels in hemodialysis patients
Background Hemoglobin (Hb) cycling in patients with renal anemia might be associated with a higher mortality rate. We investigated the association of factors relating serum ferritin and dose of erythropoiesis-stimulating agents (ESAs) with Hb levels. Methods We measured Hb and ferritin levels every...
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Published in | Clinical and experimental nephrology Vol. 16; no. 3; pp. 448 - 455 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Japan
Springer Japan
01.06.2012
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | Background
Hemoglobin (Hb) cycling in patients with renal anemia might be associated with a higher mortality rate. We investigated the association of factors relating serum ferritin and dose of erythropoiesis-stimulating agents (ESAs) with Hb levels.
Methods
We measured Hb and ferritin levels every month in 266 hemodialysis (HD) patients for 12 months.
Results
The standard deviation (SD) and residual SD (RSD) (liner regression of Hb or ferritin SD values) values of Hb were significantly correlated with ferritin SD or RSD values, respectively. The percentage achievement of target Hb in the target-ferritin group was significantly higher than in the high-amplitude fluctuation ferritin group. Ferritin SD and RSD values in patients with oral or no iron supplementation were significantly lower than those who received intravenous iron.
Conclusion
Iron storage varies over a relatively wide range in HD patients, and this variation is closely associated with Hb cycling. The stability of iron storage and ESA dosage is important for maintaining stable Hb levels. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1342-1751 1437-7799 |
DOI: | 10.1007/s10157-011-0584-0 |