Functional and structural characteristics of secretory IgA antibodies elicited by mucosal vaccines against influenza virus

• Published in: Vaccine Vol. 35; no. 39; pp. 5297 - 5302
• Main Authors: Suzuki, Tadaki, Ainai, Akira, Hasegawa, Hideki
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 18.09.2017; Elsevier Limited
• Subjects: Antibodies; Antibodies, Viral - immunology; Humans; Immune response; Immunity; Immunity, Mucosal - immunology; Immunoglobulin A; Immunoglobulin A, Secretory - immunology; Immunoglobulins; Influenza; Influenza Vaccines - immunology; Influenza Vaccines - therapeutic use; Influenza virus; Intranasal inactivated influenza vaccine; mechanism of action; mucosa; Mucosal immunity; Mucosal immunoglobulin; Mucosal vaccine; Orthomyxoviridae; Pathogens; Rodents; Secretions; Secretory IgA; Structure-function relationships; Vaccines; Vaccines, Inactivated - immunology; Vaccines, Inactivated - therapeutic use; Viruses; United States > US; Japan; Secretory IgA; Intranasal inactivated influenza vaccine; Mucosal vaccine; Influenza virus; Influenza; Mucosal immunoglobulin

Mucosal tissues are major targets for pathogens. The secretions covering mucosal surfaces contain several types of molecules that protect the host from infection. Among these, mucosal immunoglobulins, including secretory IgA (S-IgA) antibodies, are the major contributor to pathogen-specific immune r...