Type β Transforming Growth Factor: A Bifunctional Regulator of Cellular Growth

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 82; no. 1; pp. 119 - 123
• Main Authors: Roberts, Anita B., Anzano, Mario A., Wakefield, Lalage M., Roche, Nanette S., Stern, David F., Sporn, Michael B.
• Format: Journal Article
• Language: English
• Published: Washington, DC National Academy of Sciences of the United States of America 01.01.1985; National Acad Sciences
• Subjects: Animals; Biological and medical sciences; Cell Adhesion; Cell Cycle - drug effects; Cell growth; Cell Line; Cell lines; Cell physiology; Cell Transformation, Viral; Cells, Cultured; Cultured cells; Drug Interactions; Epidermal Growth Factor - pharmacology; Epithelial cells; Fibroblasts; Fibroblasts - cytology; Fundamental and applied biological sciences. Psychology; Growth Inhibitors - pharmacology; Growth Substances - pharmacology; Human growth; Kidney cells; Lungs; Melanoma; Molecular and cellular biology; Oncogenes; Peptides - pharmacology; Rats; Responses to growth factors, tumor promotors, other factors; Transforming Growth Factors; Tumor cell line; Cell proliferation; Cell culture; Vertebrata; Fixation; Mammalia; Animal; Modulation; Cell transformation; Biological activity; Tumor cell; Growth factor

Type β transforming growth factor (TGF-β ) is a two-chain polypeptide of 25,000 daltons isolated from many tissues, including bovine kidney, human placenta, and human platelets. It has been characterized by its ability to stimulate reversible transformation of nonneoplastic murine fibroblasts, as me...