Predictors of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers

• Published in: British journal of cancer Vol. 104; no. 9; pp. 1384 - 1392
• Main Authors: Metcalfe, K, Gershman, S, Lynch, H T, Ghadirian, P, Tung, N, Kim-Sing, C, Olopade, O I, Domchek, S, McLennan, J, Eisen, A, Foulkes, W D, Rosen, B, Sun, P, Narod, S A
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26.04.2011; Nature Publishing Group
• Subjects: 631/67/68; 692/699/67/1347; 692/700/565/545/546; Adult; Age; Age Factors; Aged; Biomedical and Life Sciences; Biomedicine; Breast cancer; Breast Neoplasms - diagnosis; Breast Neoplasms - genetics; Breast Neoplasms - mortality; Breast Neoplasms - pathology; Breast Neoplasms - therapy; Cancer; Cancer Research; Clinical Study; Cohort Studies; Drug Resistance; Epidemiology; Female; Genes, BRCA1; Genes, BRCA2; Genetic Predisposition to Disease; Genetics; Heterozygote; Humans; Middle Aged; Molecular Medicine; Mortality; Mutation; Neoplasms, Second Primary - diagnosis; Neoplasms, Second Primary - genetics; Neoplasms, Second Primary - mortality; Neoplasms, Second Primary - prevention & control; Odds Ratio; Oncology; Ovariectomy; Predictive Value of Tests; Risk Assessment; Risk Factors; Risk reduction; Survival Analysis; breast cancer; BRCA1; BRCA2; contralateral breast cancer

Purpose: The objective of this study was to estimate the risk of contralateral breast cancer in BRCA1 and BRCA2 carriers; and measure the extent to which host, family history, and cancer treatment-related factors modify the risk. Patients and methods: Patients were 810 women, with stage I or II brea...