Identification of sequence polymorphisms in the mitochondrial deoxyribonucleic acid displacement-loop region as risk factors for systemic lupus erythematosus

• Published in: Archives of rheumatology Vol. 36; no. 3; pp. 375 - 380
• Main Authors: Lai, Ruixue, Zhang, Xiaoyun, Qiao, Kuangyuan, Gao, Xueqing, Li, Shang, Zhang, Ruixing, Qi, Yixin, Peng, Chenxing
• Format: Journal Article
• Language: English
• Published: Turkey Turkish League Against Rheumatism 01.09.2021; Prof Sebnem Ataman, President Turkish League Against Rheumatism
• Subjects: Age; Cancer; Colorectal cancer; Confidence intervals; DNA; Females; Gastric cancer; Genetic aspects; Kidney diseases; Lupus; Mitochondrial DNA; Mutation; Original; Patients; Polymerase chain reaction; Rheumatology; Risk factors; Single nucleotide polymorphisms; Standard deviation; Statistical analysis; Systemic lupus erythematosus; China; United States > US; Displacement-loop; risk factors; systemic lupus erythematosus; sequence polymorphisms; mitochondrial deoxyribonucleic acid

Objectives: This study aims to evaluate the relationship between sequence polymorphisms (SNPs) in the displacement-loop (D-loop) region of mitochondrial deoxyribonucleic acid (mtDNA) and systemic lupus erythematosus (SLE) in Chinese female patients. Patients and methods: This cross-sectional study w...