Guided genome halving: hardness, heuristics and the history of the Hemiascomycetes

• Published in: Bioinformatics Vol. 24; no. 13; pp. i96 - i104
• Main Authors: Zheng, Chunfang, Zhu, Qian, Adam, Zaky, Sankoff, David
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.07.2008; Oxford Publishing Limited (England)
• Subjects: Algorithms; Ascomycota - genetics; Base Sequence; Chromosome Mapping - methods; Gene Duplication; Genome, Fungal - genetics; Molecular Sequence Data; Sequence Analysis, DNA - methods

Motivation: Some present day species have incurred a whole genome doubling event in their evolutionary history, and this is reflected today in patterns of duplicated segments scattered throughout their chromosomes. These duplications may be used as data to ‘halve’ the genome, i.e. to reconstruct the...