Sirtuin 6 Regulates the Activation of the ATP/Purinergic Axis in Endothelial Cells

• Published in: International journal of molecular sciences Vol. 24; no. 7; p. 6759
• Main Authors: Astigiano, Cecilia, Piacente, Francesco, Laugieri, Maria Elena, Benzi, Andrea, Di Buduo, Christian A, Miguel, Carolina P, Soncini, Debora, Cea, Michele, Antonelli, Antonella, Magnani, Mauro, Balduini, Alessandra, De Flora, Antonio, Bruzzone, Santina
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.04.2023; MDPI
• Subjects: Adenosine Triphosphate; Angiogenesis; ATP; Calcium influx; Calcium ions; Cell adhesion & migration; Cell proliferation; Connexin 43; Cytokines; Efflux; Endothelial cells; Endothelium; Enzymes; Human Umbilical Vein Endothelial Cells - metabolism; Humans; Inflammation; Leukocytes; NAD; Permeability; Proteases; purinergic receptors; SIRT6; Sirtuins - metabolism; Tumor Necrosis Factor-alpha - pharmacology; Tumor necrosis factor-α; Umbilical vein; NAD; endothelium; purinergic receptors; SIRT6; inflammation; ATP

Sirtuin 6 (SIRT6) is a member of the mammalian NAD -dependent deac(et)ylase sirtuin family. SIRT6's anti-inflammatory roles are emerging increasingly often in different diseases and cell types, including endothelial cells. In this study, the role of SIRT6 in pro-inflammatory conditions was inve...