Optimization of Supervised Cluster Analysis for Extracting Reference Tissue Input Curves in (R)-[11C]PK11195 Brain PET Studies

• Published in: Journal of cerebral blood flow and metabolism Vol. 32; no. 8; pp. 1600 - 1608
• Main Authors: Yaqub, Maqsood, van Berckel, Bart NM, Schuitemaker, Alie, Hinz, Rainer, Turkheimer, Federico E, Tomasi, Giampaolo, Lammertsma, Adriaan A, Boellaard, Ronald
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.08.2012; Nature Publishing Group; Sage Publications Ltd
• Subjects: Adult; Aged; Aged, 80 and over; Algorithms; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - physiopathology; Alzheimer's disease; Biological and medical sciences; Blood Volume - physiology; Blood. Blood coagulation. Reticuloendothelial system; Brain; Carbon Radioisotopes; Cerebellum; Cerebellum - blood supply; Cerebellum - diagnostic imaging; Cerebral blood flow; Cluster Analysis; Cognitive ability; Cognitive Dysfunction - diagnostic imaging; Cognitive Dysfunction - physiopathology; Computer Simulation; Data processing; Humans; Image Interpretation, Computer-Assisted; Isoquinolines - pharmacokinetics; Kinetics; Medical sciences; Middle Aged; Models, Neurological; Neurodegenerative diseases; Neurology; Original; Pharmacology. Drug treatments; Positron emission tomography; Positron-Emission Tomography - methods; Protein Binding; Protein transport; Reference Values; Reproducibility of Results; Thalamus - blood supply; Thalamus - diagnostic imaging; Tissue Distribution; Vascular diseases and vascular malformations of the nervous system; Young Adult; parametric analysis; clustering; (R)-[11C]PK11195; reference tissue; Cluster analysis; Nervous system diseases; Optimization; Cerebral disorder; Encephalon; C]PK11195; Central nervous system disease; Positron emission tomography; (R)-; Cerebrovascular disease; Emission tomography

Performance of two supervised cluster analysis (SVCA) algorithms for extracting reference tissue curves was evaluated to improve quantification of dynamic (R)-[11C]PK11195 brain positron emission tomography (PET) studies. Reference tissues were extracted from images using both a manually defined cer...