Optimization of Supervised Cluster Analysis for Extracting Reference Tissue Input Curves in (R)-[11C]PK11195 Brain PET Studies - Yaqub, Maqsood; van Berckel, Bart NM; Schuitemaker, Alie; Hinz, Rainer; Turkheimer, Federico E; Tomasi, Giampaolo; Lammertsma, Adriaan A; Boellaard, Ronald (Journal of cerebral blood flow and metabolism, 2012)
Keywords: Adult; Aged; Aged, 80 and over; Algorithms; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - physiopathology; Alzheimer's disease; Biological and medical sciences; Blood Volume - physiology; Blood. Blood coagulation. Reticuloendothelial system; Brain; Carbon Radioisotopes; Cerebellum; Cerebellum - blood supply; Cerebellum - diagnostic imaging; Cerebral blood flow; Cluster Analysis; Cognitive ability; Cognitive Dysfunction - diagnostic imaging; Cognitive Dysfunction - physiopathology; Computer Simulation; Data processing; Humans; Image Interpretation, Computer-Assisted; Isoquinolines - pharmacokinetics; Kinetics; Medical sciences; Middle Aged; Models, Neurological; Neurodegenerative diseases; Neurology; Original; Pharmacology. Drug treatments; Positron emission tomography; Positron-Emission Tomography - methods; Protein Binding; Protein transport; Reference Values; Reproducibility of Results; Thalamus - blood supply; Thalamus - diagnostic imaging; Tissue Distribution; Vascular diseases and vascular malformations of the nervous system; Young Adult; parametric analysis; clustering; (R)-[11C]PK11195; reference tissue; Cluster analysis; Nervous system diseases; Optimization; Cerebral disorder; Encephalon; C]PK11195; Central nervous system disease; Positron emission tomography; (R)-; Cerebrovascular disease; Emission tomography