AID-Dependent Activation of a MYC Transgene Induces Multiple Myeloma in a Conditional Mouse Model of Post-Germinal Center Malignancies - Chesi, Marta; Robbiani, Davide F.; Sebag, Michael; Chng, Wee Joo; Affer, Maurizio; Tiedemann, Rodger; Valdez, Riccardo; Palmer, Stephen E.; Haas, Stephanie S.; Stewart, A. Keith; Fonseca, Rafael; Kremer, Richard; et al. (Cancer cell, 2008)
Keywords: AICDA (Activation-Induced Cytidine Deaminase); Animals; Antigens, Neoplasm - immunology; Cell Proliferation; CELLBIO; Codon, Terminator - genetics; Cytidine Deaminase - metabolism; Disease Models, Animal; Disease Progression; DNA Mutational Analysis; Drug Screening Assays, Antitumor; Gene Expression Profiling; Germinal Center - pathology; Humans; Immunization; Mice; Models, Biological; Molecular Sequence Data; Multiple Myeloma - enzymology; Multiple Myeloma - immunology; Multiple Myeloma - pathology; Organ Specificity; Paraproteinemias - pathology; Plasma Cells - enzymology; Plasma Cells - pathology; Protein Engineering; Proto-Oncogene Proteins c-myc - genetics; Somatic Hypermutation, Immunoglobulin - genetics; Transgenes - genetics; CELLBIO