A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2

• Published in: Nature (London) Vol. 584; no. 7819; pp. 120 - 124
• Main Authors: Shi, Rui, Shan, Chao, Duan, Xiaomin, Chen, Zhihai, Liu, Peipei, Song, Jinwen, Song, Tao, Bi, Xiaoshan, Han, Chao, Wu, Lianao, Gao, Ge, Hu, Xue, Zhang, Yanan, Tong, Zhou, Huang, Weijin, Liu, William Jun, Wu, Guizhen, Zhang, Bo, Wang, Lan, Qi, Jianxun, Feng, Hui, Wang, Fu-Sheng, Wang, Qihui, Gao, George Fu, Yuan, Zhiming, Yan, Jinghua
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.08.2020; Nature Publishing Group
• Subjects: 13/1; 13/109; 13/31; 13/51; 14/34; 631/326/596/4130; 692/699/255/2514; 692/700/459/1748; 82/103; 82/29; 82/80; 82/83; ACE2; Angiotensin; Angiotensin-Converting Enzyme 2; Animals; Antibodies; Antibodies, Neutralizing - chemistry; Antibodies, Neutralizing - immunology; Antibodies, Neutralizing - pharmacology; Antibodies, Viral - chemistry; Antibodies, Viral - immunology; Antibodies, Viral - pharmacology; Betacoronavirus - chemistry; Betacoronavirus - immunology; Binding sites; Binding, Competitive; Cell Line; Chlorocebus aethiops; Coronaviridae; Coronavirus Infections - immunology; Coronavirus Infections - virology; Coronaviruses; COVID-19; Crystallization; Crystallography, X-Ray; Enzymes; Epitopes; Female; Humanities and Social Sciences; Humans; In Vitro Techniques; Infections; Macaca mulatta - immunology; Macaca mulatta - virology; Male; Middle East respiratory syndrome; Models, Molecular; Monkeys; Monoclonal antibodies; multidisciplinary; Neutralization; Neutralization Tests; Pandemics; Peptidyl-dipeptidase A; Peptidyl-Dipeptidase A - chemistry; Peptidyl-Dipeptidase A - metabolism; Plasma; Pneumonia; Pneumonia, Viral - immunology; Pneumonia, Viral - virology; Protein Binding - drug effects; Proteins; Receptors; Respiratory diseases; SARS-CoV-2; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - antagonists & inhibitors; Spike Glycoprotein, Coronavirus - chemistry; Spike Glycoprotein, Coronavirus - immunology; Spike Glycoprotein, Coronavirus - metabolism; Steric hindrance; Vero Cells; Viral diseases; Viral Load - immunology; Viruses

An outbreak of coronavirus disease 2019 (COVID-19) 1 – 3 , caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 4 , has spread globally. Countermeasures are needed to treat and prevent further dissemination of the virus. Here we report the isolation of two specific human monoclonal...