The Double Engines and Single Checkpoint Theory of Endometriosis

• Published in: Biomedicines Vol. 10; no. 6; p. 1403
• Main Authors: Hsu, Che-Fang, Khine, Aye Aye, Huang, Hsuan-Shun, Chu, Tang-Yuan
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 14.06.2022; MDPI
• Subjects: Achilles tendon; Amenorrhea; Birth control; Cancer; Carcinogens; Development and progression; Endometriosis; Endometrium; Enzymes; Estrogens; Fallopian tube; Fallopian tubes; Genetic aspects; Genomes; Health aspects; Hormones; hypermutation; Immune checkpoint; Immunity; Immunological tolerance; Immunosurveillance; Insulin-like growth factors; Localization; Menstruation; Metastases; Mutagenesis; Neoantigens; Oophorectomy; Ovaries; Ovulation; PD-1 protein; Peritoneum; Physiological aspects; Pili; retrograde menstruation; Review; Risk factors; Self; Uterus; Taiwan

Endometriosis is a chronic disease characterized by the ectopic localization of the endometrial tissue in the peritoneal cavity. Consequently, it causes local pathological changes and systemic symptoms, affecting at least one in every ten women. This disease is difficult to diagnose early, it is pro...