CNS effects of CB2 cannabinoid receptors: beyond neuro-immuno-cannabinoid activity

• Published in: Journal of psychopharmacology (Oxford) Vol. 26; no. 1; p. 92
• Main Authors: Onaivi, Emmanuel S, Ishiguro, Hiroki, Gu, Shanzhi, Liu, Qing-Rong
• Format: Journal Article
• Language: English
• Published: United States 01.01.2012
• Subjects: Animals; Cannabinoids - genetics; Cannabinoids - immunology; Cannabinoids - metabolism; Central Nervous System - immunology; Central Nervous System - metabolism; Central Nervous System - physiology; Humans; Neurons - immunology; Neurons - metabolism; Neurons - physiology; Receptor, Cannabinoid, CB2 - genetics; Receptor, Cannabinoid, CB2 - immunology; Receptor, Cannabinoid, CB2 - metabolism

There are two well characterized cannabinoid receptors (CBRs), CB1-Rs and CB2-Rs, with other candidates, such as GPR55, PPARs and vanilloid TRPV1 (VR1) receptors, which are either activated by cannabinoids and/or endocannabinoids (eCBs). The neuronal and functional expression of CB2-Rs in the brain...