Clinical Outcomes of 3D-Printed Bioresorbable Scaffolds for Bone Tissue Engineering—A Pilot Study on 126 Patients for Burrhole Covers in Subdural Hematoma

Burrhole craniostomy is commonly performed for subdural hematoma (SDH) evacuation, but residual scalp depressions are often cosmetically suboptimal for patients. OsteoplugTM, a bioresorbable polycaprolactone burrhole cover, was introduced by the National University Hospital, Singapore, in 2006 to co...

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Published inBiomedicines Vol. 10; no. 11; p. 2702
Main Authors Toh, Emma M. S, Thenpandiyan, Ashiley A, Foo, Aaron S. C, Zhang, John J. Y, Lim, Mervyn J. R, Goh, Chun Peng, Dinesh, Nivedh, Vedicherla, Srujana V, Yang, Ming, Teo, Kejia, Yeo, Tseng Tsai, Nga, Vincent D. W
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 26.10.2022
MDPI
Subjects
3D printing
Anticoagulants
Biological products
Biomedical materials
bioresorbable
Blood
Brain
burrhole cover
Catheters
chronic subdural hemorrhage
Clinical outcomes
cosmetic outcomes
Design
Dura mater
FDA approval
Hematoma
Medical imaging
Medical records
Medical research
Medicine, Experimental
Meninges
Neurosurgery
Patients
Polycaprolactone
Properties
Quality of life
Review boards
Scalp
Skin
Tissue engineering
Transplants & implants
Singapore
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Abstract Burrhole craniostomy is commonly performed for subdural hematoma (SDH) evacuation, but residual scalp depressions are often cosmetically suboptimal for patients. OsteoplugTM, a bioresorbable polycaprolactone burrhole cover, was introduced by the National University Hospital, Singapore, in 2006 to cover these defects, allowing osseous integration and vascular ingrowth. However, the cosmetic and safety outcomes of OsteoplugTM-C—the latest (2017) iteration, with a chamfered hole for subdural drains—remain unexplored. Data were collected from a single institution from April 2017 to March 2021. Patient-reported aesthetic outcomes (Aesthetic Numeric Analog (ANA)) and quality of life (EQ-5D-3L including Visual Analog Scale (VAS)) were assessed via telephone interviews. Clinical outcomes included SDH recurrence, postoperative infections, and drain complications. OsteoplugTM-C patients had significantly higher satisfaction and quality of life compared to those without a burrhole cover (ANA: 9 [7, 9] vs. 7 [5, 8], p = 0.019; VAS: 85 [75, 90] vs. 70 [50, 80], p = 0.021), and the absence of a burrhole cover was associated with poorer aesthetic outcomes after multivariable adjustment (adjusted OR: 4.55, 95% CI: 1.09–22.68, p = 0.047). No significant differences in other clinical outcomes were observed between OsteoplugTM-C, OsteoplugTM, or no burrhole cover. Our pilot study supports OsteoplugTM-C and its material polycaprolactone as suitable adjuncts to burrhole craniostomy, improving cosmetic outcomes while achieving comparable safety outcomes.
AbstractList Burrhole craniostomy is commonly performed for subdural hematoma (SDH) evacuation, but residual scalp depressions are often cosmetically suboptimal for patients. OsteoplugTM, a bioresorbable polycaprolactone burrhole cover, was introduced by the National University Hospital, Singapore, in 2006 to cover these defects, allowing osseous integration and vascular ingrowth. However, the cosmetic and safety outcomes of OsteoplugTM-C—the latest (2017) iteration, with a chamfered hole for subdural drains—remain unexplored. Data were collected from a single institution from April 2017 to March 2021. Patient-reported aesthetic outcomes (Aesthetic Numeric Analog (ANA)) and quality of life (EQ-5D-3L including Visual Analog Scale (VAS)) were assessed via telephone interviews. Clinical outcomes included SDH recurrence, postoperative infections, and drain complications. OsteoplugTM-C patients had significantly higher satisfaction and quality of life compared to those without a burrhole cover (ANA: 9 [7, 9] vs. 7 [5, 8], p = 0.019; VAS: 85 [75, 90] vs. 70 [50, 80], p = 0.021), and the absence of a burrhole cover was associated with poorer aesthetic outcomes after multivariable adjustment (adjusted OR: 4.55, 95% CI: 1.09–22.68, p = 0.047). No significant differences in other clinical outcomes were observed between OsteoplugTM-C, OsteoplugTM, or no burrhole cover. Our pilot study supports OsteoplugTM-C and its material polycaprolactone as suitable adjuncts to burrhole craniostomy, improving cosmetic outcomes while achieving comparable safety outcomes.
Burrhole craniostomy is commonly performed for subdural hematoma (SDH) evacuation, but residual scalp depressions are often cosmetically suboptimal for patients. Osteoplug TM , a bioresorbable polycaprolactone burrhole cover, was introduced by the National University Hospital, Singapore, in 2006 to cover these defects, allowing osseous integration and vascular ingrowth. However, the cosmetic and safety outcomes of Osteoplug TM -C—the latest (2017) iteration, with a chamfered hole for subdural drains—remain unexplored. Data were collected from a single institution from April 2017 to March 2021. Patient-reported aesthetic outcomes (Aesthetic Numeric Analog (ANA)) and quality of life (EQ-5D-3L including Visual Analog Scale (VAS)) were assessed via telephone interviews. Clinical outcomes included SDH recurrence, postoperative infections, and drain complications. Osteoplug TM -C patients had significantly higher satisfaction and quality of life compared to those without a burrhole cover (ANA: 9 [7, 9] vs. 7 [5, 8], p = 0.019; VAS: 85 [75, 90] vs. 70 [50, 80], p = 0.021), and the absence of a burrhole cover was associated with poorer aesthetic outcomes after multivariable adjustment (adjusted OR: 4.55, 95% CI: 1.09–22.68, p = 0.047). No significant differences in other clinical outcomes were observed between Osteoplug TM -C, Osteoplug TM , or no burrhole cover. Our pilot study supports Osteoplug TM -C and its material polycaprolactone as suitable adjuncts to burrhole craniostomy, improving cosmetic outcomes while achieving comparable safety outcomes.
Burrhole craniostomy is commonly performed for subdural hematoma (SDH) evacuation, but residual scalp depressions are often cosmetically suboptimal for patients. Osteoplug[sup.TM] , a bioresorbable polycaprolactone burrhole cover, was introduced by the National University Hospital, Singapore, in 2006 to cover these defects, allowing osseous integration and vascular ingrowth. However, the cosmetic and safety outcomes of Osteoplug[sup.TM] -C—the latest (2017) iteration, with a chamfered hole for subdural drains—remain unexplored. Data were collected from a single institution from April 2017 to March 2021. Patient-reported aesthetic outcomes (Aesthetic Numeric Analog (ANA)) and quality of life (EQ-5D-3L including Visual Analog Scale (VAS)) were assessed via telephone interviews. Clinical outcomes included SDH recurrence, postoperative infections, and drain complications. Osteoplug[sup.TM] -C patients had significantly higher satisfaction and quality of life compared to those without a burrhole cover (ANA: 9 [7, 9] vs. 7 [5, 8], p = 0.019; VAS: 85 [75, 90] vs. 70 [50, 80], p = 0.021), and the absence of a burrhole cover was associated with poorer aesthetic outcomes after multivariable adjustment (adjusted OR: 4.55, 95% CI: 1.09–22.68, p = 0.047). No significant differences in other clinical outcomes were observed between Osteoplug[sup.TM] -C, Osteoplug[sup.TM] , or no burrhole cover. Our pilot study supports Osteoplug[sup.TM] -C and its material polycaprolactone as suitable adjuncts to burrhole craniostomy, improving cosmetic outcomes while achieving comparable safety outcomes.
Audience Academic
Author Vedicherla, Srujana V
Toh, Emma M. S
Foo, Aaron S. C
Zhang, John J. Y
Dinesh, Nivedh
Thenpandiyan, Ashiley A
Nga, Vincent D. W
Lim, Mervyn J. R
Goh, Chun Peng
Yang, Ming
Teo, Kejia
Yeo, Tseng Tsai
AuthorAffiliation 1 Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore; emmatoh@u.nus.edu (E.M.S.T.); ashileyat@u.nus.edu (A.A.T.)
3 Division of Neurosurgery, Department of Surgery, Khoo Teck Puat Hospital, Singapore 768828, Singapore; yangming.yami@gmail.com
2 Division of Neurosurgery, Department of Surgery, National University Hospital, Singapore 119228, Singapore; e0366008@u.nus.edu (A.S.C.F.); zhangjohnjy@gmail.com (J.J.Y.Z.); mervynlim@u.nus.edu (M.J.R.L.); chun_peng_goh@nuhs.edu.sg (C.P.G.); nivedh.dinesh@gmail.com (N.D.); venkata.vedicherla@mohh.com.sg (S.V.V.); surteok@nus.edu.sg (K.T.); tseng_tsai_yeo@nuhs.edu.sg (T.T.Y.)
AuthorAffiliation_xml – name: 3 Division of Neurosurgery, Department of Surgery, Khoo Teck Puat Hospital, Singapore 768828, Singapore; yangming.yami@gmail.com
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Snippet Burrhole craniostomy is commonly performed for subdural hematoma (SDH) evacuation, but residual scalp depressions are often cosmetically suboptimal for...
SourceID doaj
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proquest
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crossref
SourceType Open Website
Open Access Repository
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StartPage 2702
SubjectTerms 3D printing
Anticoagulants
Biological products
Biomedical materials
bioresorbable
Blood
Brain
burrhole cover
Catheters
chronic subdural hemorrhage
Clinical outcomes
cosmetic outcomes
Design
Dura mater
FDA approval
Hematoma
Medical imaging
Medical records
Medical research
Medicine, Experimental
Meninges
Neurosurgery
Patients
Polycaprolactone
Properties
Quality of life
Review boards
Scalp
Skin
Tissue engineering
Transplants & implants
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Title Clinical Outcomes of 3D-Printed Bioresorbable Scaffolds for Bone Tissue Engineering—A Pilot Study on 126 Patients for Burrhole Covers in Subdural Hematoma
URI https://www.proquest.com/docview/2734614203
https://search.proquest.com/docview/2740502609
https://pubmed.ncbi.nlm.nih.gov/PMC9687313
https://doaj.org/article/e326761d03df438e89405bb66fac0711
Volume 10
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