Association Between Total Cell Free DNA and SARS-CoV-2 In Kidney Transplant Patients: A Preliminary Study

• Published in: Transplantation proceedings Vol. 54; no. 6; pp. 1446 - 1454
• Main Authors: Reusing, Jose Otto, Yoo, Jongwon, Desai, Amishi, Brossart, Katya, McCormick, Sarah, Malashevich, Allyson Koyen, Bloom, Michelle S., Fehringer, Gordon, White, Roseann, Billings, Paul R., Tabriziani, Hossein, Demko, Zachary P., Gauthier, Philippe, Akkina, Sanjeev K., David-Neto, Elias
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2022; The Authors. Published by Elsevier Inc
• Subjects: Biomarkers; Cell-Free Nucleic Acids; COVID-19; COVID-19 Testing; Graft Rejection; Humans; Kidney Transplantation - adverse effects; Retrospective Studies; SARS-CoV-2; Tissue Donors

Kidney transplant (KT) recipients are at high risk for developing severe COVID-19. Lowering immunosuppression levels in KT recipients with COVID-19 encourages native immune responses but can raise the risk of rejection. Donor-derived cell-free DNA (dd-cfDNA), reported as a fraction of total cfDNA, i...