Impact of Antithyroperoxidase Antibodies (Anti-TPO) on Ovarian Reserve and Early Embryo Development in Assisted Reproductive Technology Cycles

• Published in: International journal of molecular sciences Vol. 24; no. 5; p. 4705
• Main Authors: Safarian, Galina Kh, Niauri, Dariko A, Kogan, Igor Y, Bespalova, Olesya N, Dzhemlikhanova, Lyailya Kh, Lesik, Elena A, Komarova, Evgeniya M, Krikheli, Inna O, Obedkova, Ksenia V, Tkachenko, Nataliya N, Milyutina, Yulia P, Gzgzyan, Aleksandr M, Shoenfeld, Yehuda
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 28.02.2023; MDPI
• Subjects: Antibodies; AT-TPO; Autoantibodies - immunology; Autoimmunity; Efficiency; Embryo; Embryonic development; Embryonic Development - immunology; Embryos; Endocrine disorders; Female; Fertility; Fertilization; Follicular fluid; Humans; In vitro fertilization; Infertility; Infertility, Female - etiology; Infertility, Female - therapy; Investigations; Iodide peroxidase; Iodide Peroxidase - immunology; Medical research; Medicine, Experimental; Morbidity; ovarian reserve; Ovarian Reserve - immunology; Ovaries; Peroxidase; Reproductive technologies; Sperm Injections, Intracytoplasmic; Stimulation; thyroid autoimmunity; Thyroid diseases; Thyroid gland; Thyroiditis, Autoimmune - complications; Viral antibodies; Womens health; IVF; thyroid autoimmunity; AT-TPO; embryo; ovarian reserve; infertility; follicular fluid
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms24054705

Autoimmune thyroid disease (AITD) is one of the most common endocrinopathies and is more prevalent in women. It becomes evident that the circulating antithyroid antibodies that often follow AITD have effects on many tissues, including ovaries, and therefore that this common morbidity might have an impact on female fertility, the investigation of which is the aim of the present research. Ovarian reserve, ovarian response to stimulation and early embryo development in infertile patients with thyroid autoimmunity were assessed in 45 women with thyroid autoimmunity and 45 age-matched control patients undergoing infertility treatment. It was demonstrated that the presence of anti-thyroid peroxidase antibodies is associated with lower serum anti-Müllerian hormone levels and antral follicle count. Further investigation revealed the higher prevalence of sub-optimal response to ovarian stimulation in TAI-positive women, lower fertilization rate and lower number of high-quality embryos in this group of patients. The cut-off value for follicular fluid anti-thyroid peroxidase antibody affecting the above-mentioned parameters was determined to be 105.0 IU/mL, highlighting the necessity of closer monitoring in couples seeking infertility treatment with ART.