Identification of PET radiometabolites by cytochrome P450, UHPLC/Q-ToF-MS and fast radio-LC: applied to the PET radioligands [11C]flumazenil, [18F]FE-PE2I, and [11C]PBR28 - Amini, Nahid; Nakao, Ryuji; Schou, Magnus; Halldin, Christer (Analytical and bioanalytical chemistry, 2013)
Keywords: Acetamides - chemistry; Acetamides - metabolism; Acids; Analytical Chemistry; Animals; Biochemistry; Biocompatibility; Biomedical materials; Brain research; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Chromatography; Chromatography, High Pressure Liquid - methods; Collectors; Cytochrome; Cytochrome P-450 Enzyme System - chemistry; Cytochrome P-450 Enzyme System - metabolism; Dehydrogenases; Female; Flumazenil - chemistry; Flumazenil - metabolism; Food Science; Glucose; Haplorhini; Humans; Identification; In vitro testing; In vivo testing; In vivo tests; Kinetics; Laboratory Medicine; Ligands; Liquid chromatography; Liver; Male; Mass spectrometry; Mass Spectrometry - methods; Metabolites; Microsomes, Liver - chemistry; Microsomes, Liver - metabolism; Monitoring/Environmental Analysis; Original Paper; Positron emission; Positron-Emission Tomography; Proteins; Pyridines - chemistry; Pyridines - metabolism; R&D; Radiopharmaceuticals - chemistry; Radiopharmaceuticals - metabolism; Research & development; Scientific imaging; Surgical implants; Tomography; Sweden; Positron emission tomography (PET) radioligands; Ultra high-performance liquid chromatography/quadrupole-time of flight-mass spectrometry (UHPLC/Q-ToF-MS); Radiometabolites; Fast radio-liquid chromatography (radio-LC); Cytochrome P450