Mechanism of action deconvolution of the small-molecule pathological tau aggregation inhibitor Anle138b

• Published in: Alzheimer's research & therapy Vol. 15; no. 1; pp. 52 - 21
• Main Authors: Hosseini-Gerami, Layla, Ficulle, Elena, Humphryes-Kirilov, Neil, Airey, David C., Scherschel, James, Kananathan, Sarubini, Eastwood, Brian J., Bose, Suchira, Collier, David A., Laing, Emma, Evans, David, Broughton, Howard, Bender, Andreas
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 14.03.2023; BioMed Central; BMC
• Subjects: Alzheimer Disease - genetics; Alzheimer's disease; Animals; Apoptosis; Benzodioxoles - pharmacology; Bioinformatics; Biomolecules; Brain research; Cognition & reasoning; Drug therapy; Gene expression; Health aspects; Humans; Kinases; Ligands; Machine learning; Metabolism; Mice; Network biology; Pathology; Pharmaceutical research; Phosphorylation; Proteins; Pyrazoles - pharmacology; Rats; Tau; Tau proteins; tau Proteins - metabolism; Tauopathies - drug therapy; Transcriptomics; Weaning; United Kingdom; Network biology; Tau; Transcriptomics; Bioinformatics; Machine learning

A key histopathological hallmark of Alzheimer's disease (AD) is the presence of neurofibrillary tangles of aggregated microtubule-associated protein tau in neurons. Anle138b is a small molecule which has previously shown efficacy in mice in reducing tau aggregates and rescuing AD disease phenot...