Mechanism of action deconvolution of the small-molecule pathological tau aggregation inhibitor Anle138b - Hosseini-Gerami, Layla; Ficulle, Elena; Humphryes-Kirilov, Neil; Airey, David C.; Scherschel, James; Kananathan, Sarubini; Eastwood, Brian J.; Bose, Suchira; Collier, David A.; Laing, Emma; Evans, David; Broughton, Howard; et al. (Alzheimer's research & therapy, 2023)
Keywords: Alzheimer Disease - genetics; Alzheimer's disease; Animals; Apoptosis; Benzodioxoles - pharmacology; Bioinformatics; Biomolecules; Brain research; Cognition & reasoning; Drug therapy; Gene expression; Health aspects; Humans; Kinases; Ligands; Machine learning; Metabolism; Mice; Network biology; Pathology; Pharmaceutical research; Phosphorylation; Proteins; Pyrazoles - pharmacology; Rats; Tau; Tau proteins; tau Proteins - metabolism; Tauopathies - drug therapy; Transcriptomics; Weaning; United Kingdom; Network biology; Tau; Transcriptomics; Bioinformatics; Machine learning