YTHDF1 in periaqueductal gray inhibitory neurons contributes to morphine withdrawal responses in mice

• Published in: BMC medicine Vol. 22; no. 1; pp. 406 - 20
• Main Authors: Ou, Chaopeng, Zhang, Kun, Mu, Yanyu, Huang, Zhenzhen, Li, Xile, Huang, Wan, Wang, Yan, Zeng, Weian, Ouyang, Handong
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 20.09.2024; BioMed Central; BMC
• Subjects: Addictions; Animals; Aversion; Binding proteins; c-Fos protein; Calcium signalling; Care and treatment; Cholecystokinin; Cytokines; Dendritic spines; Development and progression; Diarrhea; Disease Models, Animal; Drug abuse; Drug tolerance; Drug withdrawal; Drug withdrawal symptoms; Gene sequencing; Genetic aspects; Health aspects; Hyperalgesia; Inflammation; Inflammatory response; Inhibitory neuron; Laboratories; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Morphine; Morphine - pharmacology; Morphine habit; Morphine withdrawal; N6-methyladenosine; Narcotics; Nervous system; Neuromodulation; Neurons; Neurons - metabolism; Opioids; Pain perception; Parvalbumin; Periaqueductal gray; Periaqueductal Gray - metabolism; Periaqueductal gray area; Phosphorylation; Physiological aspects; Proteins; RNA viruses; RNA-binding protein; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; Sequence analysis; Somatostatin; Substance Withdrawal Syndrome - metabolism; Transcription factors; Transfection; Transgenic mice; Tumor necrosis factor-TNF; Withdrawal; YTHDF1; China; Periaqueductal gray; YTHDF1; Somatostatin; Morphine withdrawal; Inhibitory neuron

Physical symptoms and aversion induced by opioid withdrawal strongly affect the management of opioid addiction. YTH N6-methyladenosine (m A) RNA binding protein 1 (YTHDF1), an m A-binding protein, from the periaqueductal gray (PAG) reportedly contributes to morphine tolerance and hyperalgesia. Howev...