Impaired decision-making in opiate-dependent subjects: Effect of pharmacological therapies

• Published in: Drug and alcohol dependence Vol. 83; no. 2; pp. 163 - 168
• Main Authors: Pirastu, R., Fais, R., Messina, M., Bini, V., Spiga, S., Falconieri, D., Diana, M.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 28.06.2006; Elsevier Science
• Subjects: Addictive behaviors; Adult; Adult and adolescent clinical studies; Biological and medical sciences; Buprenorphine; Buprenorphine - therapeutic use; Cognition Disorders - diagnosis; Cognition Disorders - epidemiology; Cognitive functioning; Cognitive functions; Decision Making; Drug addiction; Female; Gambling; Gambling - psychology; Gambling task; Humans; Male; Medical sciences; Methadone; Methadone - therapeutic use; Middle Aged; Narcotic Antagonists - therapeutic use; Neuropsychological Tests; Opioid-Related Disorders - epidemiology; Opioid-Related Disorders - rehabilitation; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Severity of Illness Index; Toxicology; Decision-making; Methadone; Buprenorphine; Cognitive functions; Humans; Gambling task; Human; Drug addiction; Replacement therapy; Poison withdrawal; Decision making; Psychology; Opiates; Cognition; Narcotic analgesic; Gambling game; Chemotherapy; Addiction; Psychopathology; Psychiatry

Cognitive dysfunction is a major feature of drug addiction. In the present paper, we compared the decision-making ability using the Iowa gambling task of methadone- and buprenorphine-maintained individuals to non opiate-dependent drug-free controls. Buprenorphine-maintained individuals performed bet...