Intensified conditioning containing decitabine versus standard myeloablative conditioning for adult patients with KMT2A-rearranged leukemia: a multicenter retrospective study

• Published in: BMC medicine Vol. 22; no. 1; pp. 605 - 11
• Main Authors: Hu, Zhongli, Feng, Zinan, Liu, Shiqi, He, Hai, Dong, Ying, Fan, Zhiping, Li, Yiqing, Huang, Fen, Xu, Na, Liu, Can, Zeng, Yunxin, Zhu, Ping, Lin, Ren, Jin, Hua, Zhang, Xiong, Sun, Ruijuan, Liu, Qifa, Xuan, Li
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 31.12.2024; BioMed Central; BMC
• Subjects: 5-aza-2'-deoxycytidine; Acute leukemia; Adolescent; Adult; Aged; Allo-HSCT; Allografts; Blood; Blood platelets; Bone marrow; Busulfan; Cancer; Care and treatment; China - epidemiology; Conditioning; Cyclophosphamide; Cytogenetics; Decitabine; Decitabine - administration & dosage; Decitabine - therapeutic use; Disease prevention; Female; Gene Rearrangement; Graft versus host disease; Graft-versus-host reaction; Hematopoietic Stem Cell Transplantation - methods; Hematopoietic stem cells; Histone-Lysine N-Methyltransferase - genetics; Humans; Intensified conditioning; Irradiation; KMT2A-r leukemia; Leukemia; Leukemia - therapy; Male; Medical diagnosis; Medical prognosis; Middle Aged; Myeloid-Lymphoid Leukemia Protein - genetics; Neutrophils; Patient outcomes; Patients; Relapse; Remission (Medicine); Retrospective Studies; Stem cell transplantation; Stem cells; Subgroups; Survival; Toxicity; Transplantation; Transplantation Conditioning - methods; Transplantation, Homologous - methods; Transplants & implants; Young Adult; China; Decitabine; Intensified conditioning; Allo-HSCT; KMT2A-r leukemia

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is recommended for patients with KMT2A-rearranged (KMT2A-r) leukemia whereas relapse remains high. We aimed to determine whether intensified conditioning containing decitabine (Dec) could reduce relapse compared with standard myeloablati...