Synergy of cAMP and calcium signaling pathways in CFTR regulation

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 114; no. 11; pp. E2086 - E2095
• Main Authors: Bozoky, Zoltan, Ahmadi, Saumel, Milman, Tal, Kim, Tae Hun, Du, Kai, Di Paola, Michelle, Pasyk, Stan, Pekhletski, Roman, Keller, Jacob P., Bear, Christine E., Forman-Kay, Julie D.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 14.03.2017
• Series: PNAS Plus
• Subjects: Binding sites; Biological Sciences; Calcium; Cystic fibrosis; Molecular biology; Mutation; Phosphorylation; PNAS Plus; Signal transduction; NMR; membrane potential assay; calmodulin; phosphorylation; cystic fibrosis

Cystic fibrosis results from mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel, leading to defective apical chloride transport. Patients also experience overactivation of inflammatory processes, including increased calcium signaling. Many investigations hav...