Ischemic Postconditioning Regulates New Cell Death Mechanisms in Stroke: Disulfidptosis

• Published in: Biomolecules (Basel, Switzerland) Vol. 14; no. 11; p. 1390
• Main Authors: Liu, Shanpeng, Wu, Qike, Xu, Can, Wang, Liping, Wang, Jialing, Liu, Cuiying, Zhao, Heng
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.11.2024; MDPI
• Subjects: Animals; Annotations; Biochemistry; Bioinformatics; Brain; Brain injury; Brain Ischemia - genetics; Brain Ischemia - metabolism; Brain Ischemia - pathology; Brain research; Cell Death; Disease Models, Animal; disulfidptosis; Gene amplification; Gene expression; Gene set enrichment analysis; Genes; Health aspects; Injuries; IPostC; Ischemia; Ischemic Postconditioning; Laboratory animals; Machine learning; Male; Methylation; Mice; Mice, Inbred C57BL; Molecular modelling; Neuroprotection; Peroxiredoxin; Peroxiredoxins - genetics; Peroxiredoxins - metabolism; PRDX1; Proteins; Sensitivity analysis; Stroke; Stroke (Disease); Stroke - genetics; Stroke - metabolism; Stroke - pathology; Tissues; China; Beijing China; disulfidptosis; stroke; PRDX1; IPostC; bioinformatics
• ISSN: 2218-273X; 2218-273X
• DOI: 10.3390/biom14111390

Background and Objective: Stroke poses a critical health issue without effective neuroprotection. We explore ischemic postconditioning’s (IPostC) potential to mitigate stroke-induced brain injury, focusing on its interaction with disulfidptosis, a novel cell death pathway marked by protein disulfide...