Susceptibility of Type I Interferon Receptor Knock-Out Mice to Heartland Bandavirus (HRTV) Infection and Efficacy of Favipiravir and Ribavirin in the Treatment of the Mice Infected with HRTV

• Published in: Viruses Vol. 14; no. 8; p. 1668
• Main Authors: Fujii, Hikaru, Tani, Hideki, Egawa, Kazutaka, Taniguchi, Satoshi, Yoshikawa, Tomoki, Fukushi, Shuetsu, Yamada, Souichi, Harada, Shizuko, Kurosu, Takeshi, Shimojima, Masayuki, Maeki, Takahiro, Lim, Chang-Kweng, Takayama-Ito, Mutsuyo, Komeno, Takashi, Nakajima, Nozomi, Furuta, Yousuke, Uda, Akihiko, Morikawa, Shigeru, Saijo, Masayuki
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 28.07.2022; MDPI
• Subjects: animal model; Animal models; Antiviral agents; Antiviral drugs; Bandavirus; blood; Dosage and administration; Drug development; Drug dosages; Drug therapy; drugs; Evaluation; favipiravir; Fever; Health aspects; Heartland bandavirus; Huaiyangshan banyangvirus; humans; Infections; Infectious diseases; Inoculation; Interferon; interferons; Laboratories; Lethal dose; lethal dose 50; Leukopenia; Mortality; Oral administration; Ribavirin; RNA; RNA polymerase; severe fever with thrombocytopenia syndrome; Solvents; Thrombocytopenia; Tick-borne diseases; Vaccines; Viruses; Japan; United States > US; China; Germany

Heartland bandavirus (HRTV) is an emerging tick-borne virus that is distributed in the United States and that causes febrile illness with thrombocytopenia and leukocytopenia. It is genetically close to Dabie bandavirus, which is well known as severe fever with thrombocytopenia syndrome (SFTS) virus...