Further Investigations of Nitroheterocyclic Compounds as Potential Antikinetoplastid Drug Candidates

• Published in: Biomolecules (Basel, Switzerland) Vol. 13; no. 4; p. 637
• Main Authors: García-Estrada, Carlos, Pérez-Pertejo, Yolanda, Domínguez-Asenjo, Bárbara, Holanda, Vanderlan Nogueira, Murugesan, Sankaranarayanan, Martínez-Valladares, María, Balaña-Fouce, Rafael, Reguera, Rosa M.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.04.2023; MDPI
• Subjects: African trypanosomiasis; Animals; Benznidazole; Chagas disease; Chagas Disease - drug therapy; Drug development; drug discovery; Drug screening; Drug therapy; Drugs; Humans; Infections; kinetoplastids; Leishmaniasis; Leishmaniasis - drug therapy; Nifurtimox; nitroheterocycles; Oral administration; Parasites; Parasitic diseases; Pharmaceutical Preparations; Protozoa; Review; sleeping sickness; Tropical diseases; Trypanosomiasis, African - drug therapy; Vectors (Biology); Zoonoses; Spain; Asia; Africa; nitroheterocycles; drug repurposing; drug discovery; Chagas disease; kinetoplastids; leishmaniasis; sleeping sickness

Due to the lack of specific vaccines, management of the trypanosomatid-caused neglected tropical diseases (sleeping sickness, Chagas disease and leishmaniasis) relies exclusively on pharmacological treatments. Current drugs against them are scarce, old and exhibit disadvantages, such as adverse effe...