Two-dimensional cell membrane chromatography guided screening of myocardial protective compounds from Yindan Xinnaotong soft capsule

• Published in: Chinese medicine Vol. 20; no. 1; pp. 5 - 13
• Main Authors: Shao, Si-Min, Ji, Xuan, Wang, Xing, Liu, Run-Zhou, Cai, Yu-Ru, Lin, Xiaobing, Zeng, Ze-Jie, Chen, Ling, Yang, Liu, Yang, Hua, Gao, Wen
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 04.01.2025; BioMed Central; BMC
• Subjects: Bioactive compounds; Bioflavonoids; Cardiovascular diseases; Cell membrane chromatography; Cell membranes; Chromatography; Efficiency; Flavones; Flavonoids; Forkhead protein; FOXO3 protein; Imidazole; Imidazole-modified silica gel; Membranes; Pharmacodynamics; Phenolic acids; Protein binding; Saponins; Signal transduction; Silica; Silica gel; Temperature; Yindan Xinnaotong soft capsule; China; United States > US; Shanghai China; Yindan Xinnaotong soft capsule; Imidazole-modified silica gel; Cell membrane chromatography

Cell membrane chromatography (CMC) is a biochromatography with a dual function of recognition and separation, offering a distinct advantage in screening bioactive compounds from Chinese medicines (CMs). Yindan Xinnaotong soft capsule (YD), a CM formulation, has been widely utilized in the treatment...